Cooperative Agreement W81XWH1720052

This Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) provides $1,086,750.00 to the Lovelace Biomedical Research Institute to support a research study on "A NOVEL ADVANCED RESUSCITATION FLUID FOR A SWINE POLYTRAUMA MODEL (TRAUMATIC BRAIN INJURY AND HEMORRHAGIC SHOCK)". The award, effective June 1, 2024 through May 31, 2026, will enable Lovelace Biomedical Research Institute, a non-profit preclinical contract...

This $8,042,749 federal Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) is funding research at The Ohio State University to enhance the safety and efficacy of low-titer Group O whole blood. The research involves determining optimal concentrations of hemopexin, haptoglobin, and transferrin to neutralize hemolytic byproducts during ex vivo storage of whole blood units. The project includes testing this protein...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $245,625 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to The Johns Hopkins University to conduct the "DELTA ECMO ABI STUDY (ASSESSING ACUTE BRAIN INJURY AFTER RAPID REDUCTION OF PACO2 UPON ECMO CANNULATION USING PORTABLE MRI AND BIOMARKERS)". This high-reward research project aims to improve understanding of the early physiologic changes and...

The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. was awarded a $277,569 cooperative agreement from the Department of Defense Uniformed Services University of the Health Sciences to develop and test acetazolamide as a treatment to extend the golden hour for trauma patients. Under the Uniformed Services University Medical Research Projects program (CFDA 12.750), the Foundation will conduct research from November 1, 2022 to April 30, 2025 to evaluate whether...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a 2-year, $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to Wayne State University in Detroit, MI. The objective of this high-risk, high-reward research project is to investigate the use of remotely administered hypothermia (RAH) to the spleen as a novel neuroprotective therapy for ischemic stroke. The research aims to determine if suppressing splenic...

The University of Washington was awarded a $507,517 Project Grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The goal of this 4-year grant is to develop novel, synthetic therapies for stabilizing trauma victims in the critical "golden hour" after injury. The key objectives are to create low-volume resuscitants that can provide fluid...

This Project Grant award of $2,461,670.00 from the Defense Health Agency's Military Medical Research and Development program (CFDA 12.420) supports the development of ErythroMer (EM), a dried, bio-inspired artificial red blood cell substitute, by Kalocyte Inc., a biotech startup. The project aims to optimize the lyophilization and reconstitution of EM to improve its oxygen binding and release properties, as well as evaluate its efficacy, pharmacokinetics, dosing, and compatibility with...

This Cooperative Agreement award from the Defense Advanced Research Projects Agency (DARPA) under the Research and Technology Development program (CFDA 12.910) provides $14,997,315 to The Johns Hopkins University to test the feasibility of managing a complex polytrauma patient from the point of injury through medical evacuation using a single intravascular cannula placed by a field medic. The award has a performance period from September 2024 to March 2027. The project involves developing...

The Department of the Army Medical Command awarded Northwestern University a $299,971 cooperative agreement from September 1, 2022 to August 31, 2024 to develop an Anesthesia Resuscitation Kit (ARK) for prolonged field care of military casualties with traumatic brain injury. The award is being made through the Military Medical Research and Development program (CFDA 12.420), which supports biomedical research that transforms healthcare for service members and the public through innovative...

This $2,218,222 Project Grant award from the Department of the Army Medical Command under the Military Medical Research and Development program (CFDA 12.420) will fund a 4-year research study led by the University of Texas at San Antonio (UTSA) to investigate the use of executive functions training, brain games, and brain stimulation for improving cognitive outcomes in individuals with mild traumatic brain injury (mTBI). The study aims to conduct a randomized controlled trial (RCT) to evaluate...