Cooperative Agreement W81XWH1620066

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $739,772 to Cian, Inc. to develop a cilia biomarker kit for brain injury diagnosis and prognosis. The key objectives are to develop monoclonal antibodies targeting two cilia-expressed proteins (Aim 1) and an immunoassay to detect these proteins in human plasma (Aim 2). This will...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the U.S. Department of Health and Human Services, under the Federal Grant Program "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286), aims to develop and assess novel frameworks for accurately predicting functional recovery following moderate-to-severe traumatic brain injury (TBI). The $389,813 award to the University of...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $628,133 Project Grant (CFDA 93.853) to Rutgers, The State University to study the "Metabolic Mechanisms of Recovery in Mild TBI" from September 1, 2024 to July 31, 2028. The research aims to determine if activating the CYPIN protein can promote functional recovery after mild traumatic brain injury (TBI) in mice. This builds on previous work identifying CYPIN as a key molecule regulating methionine levels and...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $587,521 in funding to the Regents of the University of Michigan to support research on mitochondrial modulation therapy for traumatic brain injury (TBI). The key objectives of this 5-year research project are to: (1) explore the molecular mechanisms of neurotrauma and...

This $2,888,616 Cooperative Agreement award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, will fund a multi-institutional effort to analytically validate a panel of 7 emerging blood-based biomarkers for monitoring the temporal evolution of traumatic brain injury (TBI). The project will leverage existing blood samples from large TBI studies to assess pre-analytical...

The University of Georgia Research Foundation, Inc. (UGA Research Foundation) was awarded a $379,171 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports a 2-year research project to investigate cerebrovascular dysfunction and cerebral atrophy in severe traumatic brain injury (STBI). Specifically, the project aims to: 1) Characterize...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $666,530 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Weill Medical College of Cornell University. The objective of this 5-year project is to develop an MRI-based cerebral metabolic rate of oxygen consumption (CMRO2) mapping technique to evaluate ischemic lesion viability in acute stroke patients. The project aims to validate the MRI-based CMRO2...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding the development of an innovative portable device to rapidly detect and monitor traumatic brain injury (TBI) biomarkers. The $332,122 award to Hemex Health Inc. aims to create a point-of-care diagnostic platform that can quickly analyze whole blood samples to identify elevated...

This federal Project Grant award of $571,404 from the National Institute of Neurological Disorders and Stroke (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) supports research at the University of Pittsburgh focused on developing novel therapies to promote functional recovery after traumatic brain injury (TBI). The key objectives are to investigate how the adipokine hormone adiponectin can protect neurons, restore white matter, and improve cognitive...

This $158,247 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research into the cell-specific neurodegenerative potential of mitochondria following traumatic brain injury (TBI). The project aims to study how TBI-induced disruptions in mitochondrial function contribute to the development of Alzheimer's-like neurodegeneration over time. Key objectives include determining injury-induced intracellular and extracellular alterations in...