Cooperative Agreement W81XWH1120096

This $392,634 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to further develop a novel nanoimmunotherapeutic approach to combat multidrug-resistant (MDR) bacterial infections. The key objectives are to design, fabricate, characterize, and optimize a red blood cell membrane-coated, hemoglobin-encapsulating nanoparticle (RHNP) that can sensitize bacteria to host oxidant...

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $296,256 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) to Advanced Molecular Healix Inc. for the project "USE OF HIF-1ALPHA MRNA TO PROMOTE PEDICLE FLAP HEALING." The goal is to create a novel therapeutic strategy for enhancing pedicle flap survival by increasing hypoxia-inducible factor-1A (HIF-1A) in wounds to promote cell...

Aumenta Biosciences Inc. received a $578,388 project grant from the National Institute of Allergy and Infectious Diseases within the Department of Health and Human Services to develop a bacterially-derived product to enhance immunity and response to immune checkpoint therapy. The Allergy and Infectious Diseases Research program aims to support biomedical research and training in infectious diseases and related areas. Under this award, Aumenta will determine the maximum tolerated dose and dose...

This $367,577 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) to Adepthera LLC aims to develop a regenerative peptide therapy to accelerate pressure ulcer healing. Specifically, the award will fund research to identify an optimal formulation of a self-assembling adrenomedullin (ADM) analog gel that can improve local blood circulation and wound healing in aging and diabetic mouse models. The proposed therapy would be administered weekly or biweekly via...

This federal Project Grant award of $425,226, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to engineer "Biomaterial Technologies to Train Innate Immunity." The project aims to establish the feasibility of using biomaterial implants to control the systemic innate immune response and induce desired changes in trained innate immunity. Specifically, the research will...

This $250,000 National Science Foundation project grant supports the development of a microneedle-mediated adaptive phototherapy wound dressing by the University of South Florida from October 1, 2022 to November 30, 2024. The dressing integrates self-diagnosis and treatment tailored to wound conditions without external electronics or medical professionals. Microstructured microneedles act as optical waveguides to deliver localized blue or red light therapy at wound sites, changing wavelength...

This Project Grant award of $430,760 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) aims to establish a strategy to improve host defense against the gram-negative bacterium Pseudomonas aeruginosa, which poses a serious threat of hospital-acquired infections, especially ventilator-associated pneumonia. The research will investigate how a single low dose of ultrapure LPS can train the...

This Project Grant award of $735,078 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at the University of Chicago to investigate the molecular mechanisms underlying innate immune memory and trained immunity in humans. The key objectives are to: 1) Characterize the epigenetic changes induced in human myeloid and lymphoid progenitor cells by trained immunity adjuvants, 2) Determine how these epigenetic...

The National Institute on Aging (NIA) awarded a $295,923 Project Grant (CFDA 93.866 - Aging Research) to Larix Bioscience LLC to develop novel hormonal therapeutics and study their efficacy with adult stem cells for the treatment of chronic pressure ulcers. The project aims to generate stable, bioactive hormone fusion biologics and evaluate their ability to enhance tissue regeneration in pressure ulcer patients, both alone and in combination with adipose-derived or induced pluripotent stem...

The Project Grant titled "NOVEL BURN SEPSIS PROGNOSTIC STRATEGIES: DECIPHERING EARLY IMMUNE PROGENITOR SHIFTS IN BURN SEPSIS DEVELOPMENT AND MODULATION OF HOST BURN RESPONSE THROUGH ANGIOPOIETIN-TIE SIGNALING" was awarded by the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) to Loyola University of Chicago's Health Sciences Campus. The $423,500 grant, awarded on August 5, 2025, aims to address two critical challenges in...