Harvard clinical and translational science center

Active Cooperative Agreement Awarded Last action

Award ID
UM1TR004408
Recipient
Awarding agency
Obligated
$107,832,469

Award facts

Completion date 50% complete
Place of performance
Boston, MA 02115, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Clinical and translational research (CTR) across harvard is conducted at 17 independent and geographically dispersed institutions, including harvard medical school (HMS), harvard t. H. Chan school of public health, and 15 HMS-affiliated academic health care centers. Each of these institutions is fiscally and operationally independent with their own governance, faculty, IRB, and electronic health records. Harvard catalyst (HC) serves as the sole coordinating entity for CTR and has brought these institutions together as a federated CTR network. Since 2008, HC has developed a substantial portfolio of educational and CTR resources to meet the needs of the CTR workforce at harvard and, when their value has been demonstrated at harvard, disseminated them to the ctsa consortium. Moving forward, HC's overarching vision is to partner with our CTR workforce, institutions, and communities to become a living clinical and translational science (CTS) learning laboratory. The CTS learning laboratory will continuously assess and reassess the hub's CTR strengths and weaknesses, developing and implementing programmatic innovations to improve the efficiency, quality, effectiveness, and impact of CTR. Using the principles and methodologies of CTS and guided by a logic model, HC is committed to achieving these goals and overcoming translational roadblocks. Seven translational roadblocks have been prioritized that can be mitigated or overcome: 1) educational resources are not reaching all learners and have been focused on investigators, rather than investigational teams; 2) extensive research resources are frequently invisible and difficult to access; 3) substantial structural and regulatory barriers limit cross-institutional collaborations; 4) research and clinical data need to be connected and their access democratized; 5) CTR workforce is not sufficiently diverse and must be grown in all domains; 6) there is limited access to and participation by diverse populations in research; and 7) insufficient mechanisms exist to support implementation of CTR evidence into practice. HC will also focus on better understanding and meeting the needs of early-stage and underrepresented in medicine investigators and their teams, as well as diverse patient populations and communities, while working to diversify the workforce and reduce health inequities. Multiple initiatives are proposed to address five specific aims: 1) train and diversify the CTR workforce; 2) connect trainees and CTR teams with HC resources; 3) partner with community stakeholders to improve research participation; 4) democratize health informatics; and 5) use CTS to overcome significant CTR roadblocks. HC is eager to learn from other ctsa hubs and is committed to dissemination and sharing across the ctsa consortium. The insights derived from employing CTS approaches will be used to overcome translational roadblocks and advance the collective national goal of improving human health.

Transactions

Action Obligated Date
Amendment $0
Amendment $0
Amendment $10,847,317
Amendment $10,847,317
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $10,539,800
Amendment $10,539,800
Amendment Harvard clinical and translational science center - clinical and translational research (CTR) across harvard is conducted at 17 independent and geographically… $10,539,800
Amendment $193,302
Amendment $10,834,704
Amendment $10,834,704
Amendment $10,904,204
Original award $10,904,204
Show all 18

Subawards

Subrecipient Amount Awarded
The Children's Hospital Corporation Boston Children’s Hospital (BCH) will participate in this project to develop and validate a machine-learning based computational framework that integrates… $89,000
Brigham & Womens Hospital Inc. Dr. Olson will oversee all phases of the study to ensure the successful completion of the outlined research objectives. As the Principal Investigator, Dr. Olson… $140,227
Brigham & Womens Hospital Inc. This work will develop and evaluate innovative LLM-based systems that will enhance ClinicalTrials.gov to better serve the needs of (1) patients and their… $268,500
The Children's Hospital Corporation This project seeks to evaluate the utility of the NeoNatal Neurobehavioral Scale-II (NNNS-II) in assessing neurodevelopmental delays in newborns with congenital… $166,939
The Children's Hospital Corporation The objective of this project is to develop a markerless motion capture approach for evaluating motor function of patients with Duchenne muscular dystrophy… $152,153
The Spaulding Rehabilitation Hospital Corporation Parkinson’s Disease (PD) is the second most common neurodegenerative disorder in the U.S., causing symptoms that worsen over time, such as tremors, slow… $126,199
The General Hospital Corporation Corinna Bauer is an assistant investigator in the Department of Radiology at Massachusetts General Hospital and has additional appointments as an Assistant… $78,535
The Children's Hospital Corporation The proposed project aims to evaluate feasibility and acceptability of electroencephalography (EEG) and genetic biomarker testing in a busy primary care clinic.… $137,794
Beth Israel Deaconess Medical Center, Inc. May 2023- April 2030 Site PI: Janet Mullington Under the Harvard CTSC proposal, Beth Israel Deaconess Medical Center (BIDMC) will participate as a Partner… $122,886
The General Hospital Corporation Dr. Quiroz will examine factors that may serve as barriers for clinical research participation in Alzheimer's Disease at two different stages: first, we will… $83,445
The Mclean Hospital Corporation The purpose of the current study is develop a set of recommendations for behavioral science researchers to recruit and engage s/r minorities and religiously… $80,716
Brigham & Womens Hospital Inc. Barbara Bierer, MD, and Selvf n Marroquf n, BS, MPH, are both employees of the Brigham and Women's Hospital, are affiliated with the Multi-Regional Clinical… $121,111
The General Hospital Corporation This study project proposes to address the chronic pain-early cognitive decline (CP-ECD) co-morbidity in the older Black community by conducting an open pilot… $83,500
Brigham & Womens Hospital Inc. Dr. Danielle Bitterman as the Principal Investigator will lead the research of the current proposal, and will be responsible for planning and directing the… $84,202
The Mclean Hospital Corporation This project aims to facilitate the inclusion of individuals with a neurocognitive deficit, including aphasia and mild cognitive impairment (MCI). The… $46,883
Trustees Of Boston University $35,010
The Schepens Eye Research Institute. Inc. Dr. Levi N. Kanu is an Instructor of Ophthalmology at Harvard Medical School and a cornea and refractive surgeon at Mass Eye and Ear. He is a clinician… $98,500
The Mclean Hospital Corporation The entirety of the project will be conducted at McLean Hospital where Dr. Webb and Dr. Harnett are based. The community of basic scientists and clinicians… $81,895
The General Hospital Corporation Massachusetts General Hospital Harvard Clinical and Translational Science Center Award STATEMENT OF WORK May 2023- April 2030 Site PI: Judy Hung Under the… $82,687
Beth Israel Deaconess Medical Center, Inc. Beth Israel Deaconess Medical Center Harvard Clinical and Translational Science Center Award May 2023- April 2030 Site PI: Janet Mullington Under the Harvard… $905,300
The General Hospital Corporation May 2023- April 2030 Site PI: Judy Hung Under the Harvard CTSC proposal, Massachusetts General Hospital (MGH) will participate as a Partner site and will be… $128,590
Dana-Farber Cancer Institute, Inc. May 2023- April 2030 Site PI: Eva Guinan Dr. Eva Guinan will provide strategic direction and leadership, working to embed additional CTS investigations onto the… $307,517
The General Hospital Corporation May 2023- April 2030 Site PI: Judy Hung Under the Harvard CTSC proposal, Massachusetts General Hospital (MGH) will participate as a Partner site and will be… $755,440
The General Hospital Corporation Under the Harvard CTSC proposal, Massachusetts General Hospital (MGH) will participate as a Partner site and will be significantly involved in the Research… $1,890,250
Beth Israel Deaconess Medical Center, Inc. May 2023- April 2030 Site PI: Janet Mullington Under the Harvard CTSC proposal, Beth Israel Deaconess Medical Center (BIDMC) will participate as a Partner… $195,172
Beth Israel Deaconess Medical Center, Inc. May 2023- April 2030 Site PI: Janet Mullington Under the Harvard CTSC proposal, Beth Israel Deaconess Medical Center (BIDMC) will participate as a Partner… $365,273
Brigham & Womens Hospital Inc. Under the Harvard CTSC proposal, Brigham and Women’s Hospital (BWH) will participate as a Partner site and will be significantly involved in the Research… $537,000
The Children's Hospital Corporation May 2023- April 2030 Site PI: Lise Nigrovic Under the Harvard CTSC proposal, Children’s Hospital Boston (BCH) will participate as a Partner site and will… $441,730
The Children's Hospital Corporation May 2023- April 2030 Site PI: Lise Nigrovic Under the Harvard CTSC proposal, Boston Children’s Hospital (BCH) will participate as a Partner site and will… $1,476,410
Dana-Farber Cancer Institute, Inc. May 2023- April 2030 Site PI: Lee Nadler As the PD/PI for this award, Dr. Nadler will have the authority and responsibility to make decisions regarding resource… $461,273
Brigham & Womens Hospital Inc. May 2023- April 2030 Site PI: Lindsey Baden Under the Harvard CTSC proposal, Brigham and Women’s Hospital (BWH) will participate as a Partner site and… $1,363,980
Beth Israel Deaconess Medical Center, Inc. May 2023- April 2030 Site PI: Janet Mullington Under the Harvard CTSC proposal, Beth Israel Deaconess Medical Center (BIDMC) will participate as a Partner… $26,916
Show all 32

Quick answers

Who received award UM1TR004408?

UM1TR004408 was awarded to President And Fellows Of Harvard College by National Center for Advancing Translational Sciences (National Institutes of Health) on May 1, 2023.

How much is award UM1TR004408 worth?

$107,832,469 has been obligated on UM1TR004408.

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