Cooperative Agreement UM1HG009444

The University of Washington was awarded a $504,949 Project Grant from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) to develop a series of machine learning models that integrate Hi-C data with other genomic data types such as RNA-seq, genome sequence, and ATAC-seq. The goal is to advance the analysis of chromatin structure and its relationship to gene expression and other cellular processes. Key objectives include: Extending the SAGITTARIUS model to...

This Cooperative Agreement award from the National Human Genome Research Institute (NHGRI), under CFDA Program 93.172 - Human Genome Research, provides $1,418,806 to the University of Washington to develop transformative tooling for accurately annotating and analyzing epigenetic data within a human pan-genome reference. The project aims to: (1) develop machine learning-based approaches to classify long-read epigenetic data; (2) create tools to integrate long-read and short-read epigenetic data...

This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), will fund the development of complementary experimental and computational strategies for high-throughput characterization of the impact of genetic variants in key regulatory and DNA repair genes. The $757,157 award to the University of California, San Diego (UC San Diego) aims to address the challenge of interpreting the functional...

The National Human Genome Research Institute (NHGRI), under the Human Genome Research (CFDA 93.172) program, awarded a $1,350,896 Project Grant to the University of California, San Diego (UCSD) to develop novel technologies for studying regulatory sequence function. The overarching goal is to create a multimodal platform using massively parallel reporter assays to elucidate the mechanisms governing transcriptional regulation by chromatin, regulatory factors, and transcriptional processes. The...

The National Human Genome Research Institute (NHGRI), through the Human Genome Research program (CFDA 93.172), awarded a $444,125 Project Grant to the Rector & Visitors of the University of Virginia (UVA) to develop computational models that accurately quantify open chromatin bias and TN5 intrinsic cleavage bias in both bulk and single-cell Cleavage Under Targets & Tagmentation (CUT & TAG) data. The models will characterize how these biases affect the detection of histone...

This $799,858 federal Project Grant awarded by the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) to Atlasxomics Inc. aims to develop a user-friendly, next-generation epigenomic chip that is adaptable to automation workflows. Specifically, the Phase I SBIR project will focus on expanding tissue type compatibility, minimizing end-user processing, and enabling adaptation into larger automation workflows for the company's spatial epigenomics platform. The effort...

This $501,191.23 Project Grant awarded by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172) supports research at the University of Texas MD Anderson Cancer Center to develop advanced computational models for analyzing single-cell genomics data. The key products and services to be delivered include: Creating a "single-cell gene-body associating domain (scGAD)" scoring system to explore 3D genome structures at the gene level and...

The National Human Genome Research Institute (NHGRI) awarded a $573,116 Cooperative Agreement under the Human Genome Research (CFDA 93.172) program to Childrens Hospital Medical Center in Cincinnati, Ohio. The purpose of this 5-year award, running from June 2024 to April 2029, is to maintain and improve the CISBP and CISBP-RNA databases, which provide comprehensive mapping of transcription factor and RNA-binding protein specificities. These databases are critical resources for understanding gene...

The National Human Genome Research Institute (NHGRI) awarded a $400,000 Project Grant (CFDA 93.172 - Human Genome Research) to the University of Washington to develop new single-cell multi-omic technologies for studying the relationship between three-dimensional genome organization and gene expression. Specifically, the grant will fund the development of CARE-Seq, a novel method to jointly measure whole-genome chromatin interactions and gene expression in the same single cells from complex...

This federal Project Grant award of $136,661 from the National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), supports the development of an innovative high-throughput PADIT-SEQ reporter assay to study the fundamental principles governing transcription factor (TF)-DNA binding specificity and affinity. The goals of this 2-year research project are to: 1) determine how medium-low affinity auxiliary binding sites and DNA shape features influence TF...