Washu-VAI somatic mosaicism across human tissues (smaht) program genome characterization center
Active Cooperative Agreement Awarded Last action
- Award ID
- UM1DA058219
- Recipient
-
The Washington University UEI L6NFUM28LQM5
- Awarding agency
-
National Institute on Drug Abuse
National Institutes of Health, Department of Health and Human Services
- Obligated
- $39,981,848
Award facts
- Assistance listing
- 93.310 Trans-NIH Research Support
- Completion date 70% complete
- Funding agency
- Office of the Director National Institutes of Health, Department of Health and Human Services
- Place of performance
- St. Louis, MO 63110, USA
Award details come from USAspending.gov.
Description
- Abstract
- The somatic mosaicism across human tissues (smaht) network aims to propel discovery of new biological processes in human health and disease that are mediated by genomic variation in somatic tissues. We propose to establish the washu-VAI somatic mosaicism across human tissues (smaht) program genome characterization center (smaht-GCC). A fundamental goal of our proposed GCC is to generate high throughput, high quality, and high consistency genomic DNA and RNA sequencing data, ands to construct a comprehensive catalogue of the human somatic variation together with other members of the network. First, we will establish and manage a collaborative, efficient, transparent, and flexible GCC as an integral component of the smaht network. We will leverage our experience in participating and leading many past and current genomics consortia to design and implement our GCC. The GCC will manage center administration, maintain high quality, sustainable, and on-time data production, develop and implement data management plans, conduct data quality assurance and integrative data analysis, and fully engage with the entire smaht network. Second, we will generate high quality, high throughput, comprehensive and sustainable genomics datasets for the characterization of human somatic mosaicism, using state-of-the-art technologies. We capitalize on our past experience in generating high quality sequencing-based genomic resources, to design and implement our data production plan. We recommend a collection of human tissue types, and will implement four core genomics assays to profile sample received from smaht tissue procurement center. We aim to deliver high throughput, high quality, and high consistency genomic DNA and RNA sequencing data to the smaht data analysis center. Third, we will develop and maintain a modern, efficient, scalable, and interactive data management and processing system that seamlessly interfaces with the smaht data analysis center. We will leverage our experience in scientific computing, information technology system, large genomic data management and integration, and community engagement to design and implement our data management plan. We will build a streamlined, efficient data infrastructure to manage GCC data and collaborate with smaht DAC. Fourth, we will develop and implement data analysis and visualization solutions for the smaht-GCC data. We will leverage our extensive experience in genomic data analysis and integration, bioinformatics tool development as well as data visualization in the implementation of our data analysis and visualization plan. We will also bring in unique expertise in analyzing transposable elements and epigenomics data. We will contribute to the network-wide data analysis, and facilitate the characterization of a full spectrum of the human somatic mosaicism.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $16,931,961 | |
| Amendment | $0 | |
| Amendment | $3,740,535 | |
| Amendment | $2,999,999 | |
| Amendment | $2,999,999 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $2,750,000 | |
| Amendment | $2,750,000 | |
| Amendment | $154,677 | |
| Amendment | $154,677 | |
| Amendment | $2,500,000 | |
| Amendment | $2,500,000 | |
| Original award | $2,500,000 |
Show all 16
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| President And Fellows Of Harvard College | $3,489,615 | |
| Brigham & Womens Hospital Inc. | $318,347 | |
| The Children's Hospital Corporation | $356,695 | |
| Van Andel Research Institute | $777,600 | |
| Dana-Farber Cancer Institute, Inc. | $296,520 | |
| President And Fellows Of Harvard College | $2,592,346 | |
| The Children's Hospital Corporation | $337,820 | |
| Brigham & Womens Hospital Inc. | $317,897 | |
| Dana-Farber Cancer Institute, Inc. | $297,372 | |
| Van Andel Research Institute | $690,587 | |
| Van Andel Research Institute | $311,509 | |
| Van Andel Research Institute | $311,509 | |
| Van Andel Research Institute | $595,459 |
Show all 13
Quick answers
Who received award UM1DA058219?
UM1DA058219 was awarded to The Washington University by National Institute on Drug Abuse (National Institutes of Health) on May 1, 2023.
How much is award UM1DA058219 worth?
$39,981,848 has been obligated on UM1DA058219.
Which agency awarded UM1DA058219?
National Institute on Drug Abuse (National Institutes of Health) awarded UM1DA058219, with funding from Office of the Director (National Institutes of Health).
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