Injection of autologous volar fibroblasts to the stump site to allow pressure adaptation and enhanced prosthetic use in amputees
Active Cooperative Agreement Awarded Last action
- Award ID
- UH3AR079376
- Recipient
-
The Johns Hopkins University UEI FTMTDMBR29C7
- Awarding agency
-
National Insititue of Arthritis and Musculoskeletal and Skin Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $5,260,918
Award facts
- Assistance listing
- 93.370 21st Century Cures Act: Regenerative Medicine Initiative
- Completion date 93% complete
- Originally
- Funding agency
- Office of the Director National Institutes of Health, Department of Health and Human Services
- Place of performance
- Baltimore, MD 21205, USA
Award details come from USAspending.gov.
Description
- Abstract
- Abstract the long term objective of the proposed research is to use cellular therapy to advance regenerative medicine. In particular, we wish to help amputees who have lost a limb. While major improvements have been made to prosthetics, the skin side of the interface at the stump site was not evolved to bear weight. The stump does not normally have the pressure adaptive abilities of the soles of the foot for example. The present grant proposes to biopsy, purify and expand fibroblasts from an existing palm or sole and inject them into the stump site of an amputee to improve their use of prosthetics. We also propose to study the basic biology behind cell therapy to understand how the injected cells change the native cells, and in turn how those native cells affect the injected cells. The results of this grant will hopefully lead to a new therapy to help not only amputees, but potentially prevent pressure ulcers and provide a platform for future cell therapies.
Transactions
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Quick answers
Who received award UH3AR079376?
UH3AR079376 was awarded to The Johns Hopkins University by National Insititue of Arthritis and Musculoskeletal and Skin Diseases (National Institutes of Health) on September 22, 2021.
How much is award UH3AR079376 worth?
$5,260,918 has been obligated on UH3AR079376.
Which agency awarded UH3AR079376?
National Insititue of Arthritis and Musculoskeletal and Skin Diseases (National Institutes of Health) awarded UH3AR079376, with funding from Office of the Director (National Institutes of Health).
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