Advancing epilepsy diagnosis with flexible, high-resolution thin-film electrodes
Active Cooperative Agreement Awarded Last action
- Award ID
- UG3NS120172
- Recipient
-
New York University UEI M5SZJ6VHUHN8 Part of New York University
- Awarding agency
-
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services
- Obligated
- $14,098,260
Award facts
- Assistance listing
- 93.372 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies
- Completion date 93% complete
- Originally
- Funding
-
- $13,959,314.00 Federal
- $138,946.00 Non-federal
- Place of performance
- New York, NY 10016, USA
Award details come from USAspending.gov.
Description
- Abstract
- To advance the development of next-generation personalized therapies for long-term seizure freedom, we urgently need technologies that improve seizure diagnostics while reducing risks associated with invasive neurosurgical procedures. Among the more than 1,000,000 americans with uncontrolled focal epilepsy, many have poorly localized seizure foci. These individuals face the highest rates of 'failure' (i.e., ongoing seizures) after epilepsy surgery. That failure reflects the biology of their epilepsy as well as the overlap of seizure foci with essential cortical areas. However, limits of current technologies also play a critical role in the high failure rate as we are currently limited in our ability to sample wide regions of the neocortex (i.e., stereoeeg) or to record broad neocortical regions without inducing pain, swelling, and neuroinflammatory tissue damage (i.e., subdural grid and strip recordings). To meet this need for safer, more effective invasive electrode studies and simultaneously enable discovery to advance next-generation therapies, this UG3/UH3 clinical trial project leverages a successful, long-term collaboration between clinicians, engineers, material scientists, neuroscientists and industrial partners at new york university school of medicine, new york university, duke university, the university of utah, blackrock microsystems, and dyconex to translate modern thin-film technology into next generation FDA-approved implantable neurological devices. We have developed and extensively tested a novel electrode array based on liquid crystal polymer thin-film (LCP-TF) technology with partner dyconex, AG. When combined with large-scale data acquisition systems, LCP-TF electrodes will provide higher quality neural recordings than existing FDA- approved electrode arrays, with improved safely and at an affordable cost. We propose to obtain traditional 510(k) approval from the FDA for short-term implantation (
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Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Blackrock Microsystems, Inc. | $524,584 | |
| The Trustees Of The University Of Pennsylvania | $212,524 | |
| Huron Consulting Services LLC | $221,051 | |
| The Trustees Of The University Of Pennsylvania | $368,944 | |
| Blackrock Microsystems, Inc. | $665,473 | |
| Duke University | $236,795 | |
| Blackrock Microsystems, Inc. | $754,436 | |
| Blackrock Microsystems, Inc. | $139,986 | |
| Duke University | $260,081 |
Quick answers
Who received award UG3NS120172?
UG3NS120172 was awarded to New York University by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on March 1, 2022.
How much is award UG3NS120172 worth?
$14,098,260 has been obligated on UG3NS120172: $13,959,314 in federal funding and $138,946 in non-federal funding.
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