This Project Grant award of $431,643, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports the development and pilot testing of a telehealth-delivered, pain-targeted motivational smoking intervention for smokers with chronic pain who are not ready to quit. The project aims to adapt an existing in-person intervention to a telehealth format and evaluate its feasibility and acceptability in a pilot randomized controlled...
This Cooperative Agreement awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $4,451,386 in funding to the University of Washington to adapt, pilot, and implement a Nurse Care Management (NCM) model for rural patients with chronic pain. The NCM model includes care coordination, cognitive behavioral therapy, and referrals to a remotely delivered exercise program. The project aims to enhance...
The U.S. National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,643,228 Cooperative Agreement grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to Worcester Polytechnic Institute (WPI) to develop an Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment (IMPACT). The key objectives of this 2-year IMPACT project are to: 1) Initiate a clinical trial of Mindfulness-Based Stress Reduction (MBSR) for chronic low back pain...
This Project Grant award of $639,882 from the National Center for Complementary and Integrative Health (NCCIH), under the federal Research and Training in Complementary and Integrative Health program (CFDA 93.213), will fund a randomized clinical trial to evaluate the efficacy of an online yoga ("teleyoga") intervention compared to Acceptance and Commitment Therapy (ACT) for treating chronic musculoskeletal pain in veterans. The study, to be conducted by the Palo Alto Veterans...
This $145,748 Project Grant award from the National Institute on Minority Health and Health Disparities (CFDA 93.307 Minority Health and Health Disparities Research) aims to address the underutilization of pain psychology treatments among socioeconomically disadvantaged individuals with chronic low back pain. The primary investigator, Dr. Fenan Rassu of Johns Hopkins University, will conduct a three-part research strategy: Analyze data to investigate the impact of socioeconomic status on pain...
The University of Washington School of Medicine, Department of Anesthesiology & Pain Medicine, was awarded a $1,425,000 Project Grant over 5 years by the Department of Health and Human Services Health Resources and Services Administration (HRSA) under the Telehealth Programs (CFDA 93.211). The grant will fund the expansion of an existing, evidence-based, ECHO-type collaborative learning and capacity building program to underserved areas in the WWAMI region (Washington, Wyoming, Alaska,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,365,011 to the University of Washington to conduct a clinical trial examining the neuromodulatory mechanisms and moderators of mindfulness meditation (MM) and self-hypnosis (HYP) for chronic pain reduction in older adults. The study will enroll 375 participants and use arterial spin labeling fMRI and EEG to investigate how these non-pharmacological treatments impact chronic pain via...
The National Center for Complementary and Integrative Health (NCCIH) awarded a $157,409 Project Grant under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to Seattle Children's Hospital to develop a mobile "just-in-time" adaptive intervention (JITAI) for young adults with chronic pain. The key objectives are to: 1) conduct an ecological momentary assessment study to identify contextual factors that predict pain exacerbations in young adults to...
This Project Grant award of $421,329 from the National Institute on Aging (NIA) Federal Grant Program CFDA 93.866 - Aging Research supports the development and preliminary testing of a peer narrative video intervention called "Reclaim Your Day" (RYD) for older adults with chronic musculoskeletal (MSK) pain. The project aims to create a 6-episode, 30-minute video series highlighting the experiences of older adults using Acceptance and Commitment Therapy (ACT) strategies to cope with...
The National Center for Complementary and Integrative Health (NCCIH), part of the National Institutes of Health (NIH), awarded a $270,857 Project Grant (CFDA 93.213 - Research and Training in Complementary and Integrative Health) to Portland State University to establish a community-based research agenda for improving chronic pain self-management among young Black adults. The 5-year award, starting September 1, 2024, will support Dr. De'Sha Wolf, an early career social scientist, in conducting...
REACHING RURAL VETERANS: APPLYING MIND-BODY SKILLS FOR PAIN USING A WHOLE HEALTH TELEHEALTH INTERVENTION (RAMP-WH) - 1 THIS PROJECT ADDRESSES THE SIGNIFICANT CHALLENGE OF IMPLEMENTING EFFECTIVE, NON-OPIOID INTERVENTIONS FOR CHRONIC PAIN 2 MANAGEMENT IN RURAL AND REMOTE DWELLING VETERAN POPULATIONS. PAIN IS A COMPLEX BIOPHYSICAL, PSYCHOLOGICAL, AND SOCIAL 3 (BPS) CONDITION AND THERE IS A GROWING EVIDENCE BASE TO SUPPORT SEVERAL COMPLEMENTARY AND INTEGRATIVE HEALTH (CIH) 4 APPROACHES, WHICH CAN ADDRESS PAIN IN A MORE HOLISTIC WAY. WHILE THE VA HAS BECOME A LEADER IN ADVANCING CIH THROUGH 5 ITS WHOLE HEALTH INITIATIVE, THERE REMAIN MANY BARRIERS, ESPECIALLY FOR RURAL PATIENTS. OUR TEAM HAS CO-DEVELOPED, WITH 6 MULTIPLE-LEVELS OF VA STAKEHOLDERS (INCLUDING RURAL PATIENTS), AN INNOVATIVE TELEHEALTH EVIDENCE-BASED INTERVENTION THAT 7 BUILDS UPON OUR TEAM'S PREVIOUS RESEARCH. THE REACHING RURAL VETERANS: APPLYING MIND-BODY SKILLS FOR PAIN USING A 8 WHOLE HEALTH TELEHEALTH INTERVENTION (RAMP-WH) PROJECT STRATEGICALLY COALESCES MULTIPLE EVIDENCE BASED CIH SELF- 9 MANAGEMENT STRATEGIES TO ADDRESS VETERANS' BPS NEEDS AND OVERCOME EXISTING BARRIERS. COMPRISED OF PAIN EDUCATION, 10 MINDFULNESS, PAIN SPECIFIC EXERCISES, AND COGNITIVE BEHAVIORAL STRATEGIES, THE PROGRAM IS COHESIVE AND SCALABLE. DESIGNED 11 TO BE IMPLEMENTED WITHIN THE VA THROUGH ITS NATIONWIDE WHOLE HEALTH SYSTEM INITIATIVE, IT USES VA WHOLE HEALTH (WH) 12 COACHES AS PROGRAM FACILITATORS. RAMP-WH IS A 12-WEEK PROGRAM INCLUDING A 1-TO-1 SESSION WITH A WH COACH, FOLLOWED 13 BY 11 GROUP SESSIONS INCLUDING PRE-RECORDED EXPERT LED EDUCATION VIDEOS, MIND-BODY SKILL TRAINING AND PRACTICE, AND 14 FACILITATED DISCUSSIONS. FOR THE PREPARATORY PHASE (UG3) WE WILL CONDUCT 1) STAKEHOLDER ENGAGEMENT ACTIVITIES INCLUDING 15 IDENTIFYING AND DEVELOPING NEW COMMUNITY PARTNERSHIPS AND USING MIXED METHODS DATA COLLECTION FROM MULTIPLE LEVELS OF 16 STAKEHOLDERS (N=35-50 PATIENTS, COMMUNITY PARTNERS, VA HEALTHCARE SYSTEM LEADERS AND STAFF), GUIDED BY THE ESTABLISHED 17 RE-AIM/PRISM FRAMEWORK, TO LEARN ABOUT KEY FACTORS THAT CAN AFFECT LONG-TERM ADOPTION; AND 2) CONDUCT A PILOT STUDY OF 18 40 RURAL VA PATIENTS WITH CHRONIC PAIN TO ASSESS THE FEASIBILITY OF DELIVERING RAMP-WH (EXPERIMENTAL INTERVENTION FOR 19 THE UH3 TRIAL) IN TERMS OF RECRUITMENT AND ENGAGEMENT, INTERVENTION FIDELITY AND ADHERENCE, DATA COLLECTION, AND OTHER KEY 20 METRICS. FOR THE UH3 PHASE, WE WILL CONDUCT A RANDOMIZED HYBRID TYPE 2 EFFECTIVENESS-IMPLEMENTATION MULTI-SITE 21 PRAGMATIC CLINICAL TRIAL OF RAMP-WH COMPARED TO USUAL CARE, AMONG RURAL PATIENTS (N=500) IN THE VA HEALTHCARE 22 SYSTEM. UH3 AIM 1 WILL ASSESS THE RELATIVE EFFECTIVENESS OF RAMP-WH IN TERMS OF THE PRIMARY EFFECTIVENESS OUTCOME 23 OF PAIN INTERFERENCE AT 13 AND 26 WEEKS AND SECONDARY OUTCOMES INCLUDING OPIOID USE AND OTHER HEAL RECOMMENDED 24 OUTCOMES. IN UH3 AIM 2 WE WILL WORK ITERATIVELY WITH MULTIPLE LEVELS OF STAKEHOLDERS (FROM UG3) TO EVALUATE 25 INTERVENTION IMPLEMENTATION STRATEGIES USED IN THE TRIAL AND ADAPT THESE STRATEGIES TO SCALE UP RAMP-WH WITHIN THE 26 NATIONAL VA HEALTHCARE SYSTEM. THIS WILL INCLUDE: A) CONDUCTING MIXED-METHODS ASSESSMENTS OF STAKEHOLDER AND 27 RANDOMIZED TRIAL PARTICIPANT VIEWS OF IMPLEMENTATION-RELATED BARRIERS AND FACILITATORS, RESOURCE NEEDS, AND OTHER RE- 28 AIM/PRISM DOMAINS; B) WORKING WITH STAKEHOLDERS TO CO-CREATE ADDITIONAL PLAUSIBLE STRATEGIES FOR OVERCOMING BARRIERS TO 29 IMPLEMENTATION OF RAMP-WH; AND C) CONDUCTING BUDGET IMPACT ANALYSES USING MODELS INFORMED BY STAKEHOLDER VIEWS TO 30 INFORM FUTURE DECISION MAKING. 31