This Cooperative Agreement award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $3,287,052 to Virogenomics Biodevelopment, Inc. to advance the development of DRHQ, an immunotherapeutic compound, as a potential treatment for stimulant use disorder, specifically methamphetamine addiction. The key objectives of this project are to: 1) determine the optimal dose and dosing schedule of DRHQ to reduce drug-taking behavior in animal models, 2) evaluate whether DRHQ can reverse central nervous system neuropathology associated with compulsive methamphetamine use, 3) complete large-scale manufacturing and toxicology studies to support an Investigational New Drug (IND) application, and 4) conduct Phase 1 clinical trials to assess the safety of DRHQ in both healthy volunteers and individuals diagnosed with methamphetamine use disorder. If found safe, this research would enable larger Phase 2 efficacy studies for this novel therapeutic approach to treating stimulant addiction.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $3.3m | 5/12/25 |