The human lung biomolecular multi-scale atlas program (hubmap-lung)
Active Cooperative Agreement Awarded Last action
- Award ID
- U54HL165443
- Recipient
-
University Of Rochester UEI F27KDXZMF9Y8
- Awarding agency
-
National Heart Lung and Blood Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $15,289,533
Award facts
- Assistance listing
- 93.310 Trans-NIH Research Support
- Completion date 83% complete
- Originally
- Funding agency
- Office of the Director National Institutes of Health, Department of Health and Human Services
- Place of performance
- Rochester, NY 14642, USA
Award details come from USAspending.gov.
Description
- Abstract
- Overall research plan the human lung biomolecular multi-scale atlas program (hubmap-lung) the human biomolecular atlas program (hubmap) is entering the production phase, with an emphasis on progressive, high sensitivity and specificity assays, prioritizing spatial biomolecular analysis. Our tissue mapping center (TMC) proposal will focus on one organ system, comprised of two lungs and related respiratory tract (trachea to alveoli) that for simplicity we refer to as the "lung". Our TMC will generate, standardize, and validate extensive data from high content, high-throughput imaging and `omics technology to produce systematic human lung tissue maps at high resolution. We will take a long view of an atlas, as a collection of 2D and 3D maps containing images, tabular data, facts about multiple locations at varying resolution, and indexes of named objects keyed to coordinates of a locational grid analogous to latitude and longitude, to cartographically present the whole range of salient features of the human lung. To accomplish this task, our center brings together investigators from five institutions, the university of rochester (urmc), university of california at SAN diego (ucsd), pacific northwest national laboratory (pnnl), university of washington (UW), and university of north carolina at chapel hill (UNC), each with complementary lung-focused academic interests, knowledge, and inter- consortia network connections and with internationally recognized expertise in lung and state-of-the-art biomolecular technologies. Our lung data provided to the hubmap data portal in phase i has been focused to single nucleus RNA-sequencing, chromatin availability and beginning spatial transcriptomics. In addition to further increasing representation of human diversity in these data types, the next phase of our TMC turns primary effort toward determining spatial organization of cells and matrices defined by not only gene expression but also proteins, protein modifications, lipids and select metabolites critical to specific cell function within anatomical and functional niches. With the recognized value of global investigative efforts within and outside the consortium, the specific aims of the TMC overall component concentrate on communication and collaboration within the TMC, between all hubmap components and synergistically among national and international researchers and consortia.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $500,000 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $2,500,000 | |
| Amendment | $2,500,000 | |
| Amendment | $199,533 | |
| Amendment | $90,000 | |
| Amendment | $2,500,000 | |
| Amendment | $2,500,000 | |
| Amendment | $2,250,000 | |
| Original award | $2,250,000 |
Show all 14
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| The University Of Queensland | $188,431 | |
| National Disease Research Interchange | $315,781 | |
| Battelle Memorial Institute | $1,253,342 | |
| Seattle Children's Hospital | $103,210 | |
| University Of North Carolina At Chapel Hill | $334,914 | |
| University Of California, San Diego | $1,039,660 | |
| University Of California, San Diego | $1,329,637 |
Quick answers
Who received award U54HL165443?
U54HL165443 was awarded to University Of Rochester by National Heart Lung and Blood Institute (National Institutes of Health) on September 1, 2022.
How much is award U54HL165443 worth?
$15,289,533 has been obligated on U54HL165443.
Which agency awarded U54HL165443?
National Heart Lung and Blood Institute (National Institutes of Health) awarded U54HL165443, with funding from Office of the Director (National Institutes of Health).
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