Stanford tissue mapping center
Ended Cooperative Agreement Awarded Last action
- Award ID
- U54HG012723
- Recipient
-
The Leland Stanford Junior University UEI HJD6G4D6TJY5
- Awarding agency
-
National Human Genome Research Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $14,182,000
Award facts
- Assistance listing
- 93.310 Trans-NIH Research Support
- Completion date
- Funding agency
- Office of the Director National Institutes of Health, Department of Health and Human Services
- Place of performance
- Palo Alto, CA 94304, USA
Award details come from USAspending.gov.
Description
- Abstract
- Abstract: overall the small bowel and colon are organs critical for maintaining homeostasis of the human body by mediating nutritional absorption upon the ingestion of food. Though both organs are extensive in length, there are known differences in function and cellular heterogeneity within different portions of each. Also, a cross section anywhere in the bowel reveals a complex layering of components involved in absorption and secretion, motility of GUT contents, circulation, and immunity. In this submission, we propose to continue our efforts in the stanford tissue mapping center (TMC) to produce multi-modal, three-dimensional single-cell resolution maps of the small bowel and colonic wall structure. This will serve as a community resource to further study intestinal function and disease. We will collect tissues from deceased organ donors with explicit consent for distribution among the hubmap consortium and broad access genome data sharing (GDS). Three sets of technologies will then be employed. Tissue samples will be subjected to single-nuclei atac-SEQ and RNA-SEQ. These open chromatin and transcriptomic profiles will be spatially mapped to tissue sections using the codex (CO-detection by indexing) multiplexed spatial immunoassay. We will also employ the molecular cartography multiplexed fluorescence in situ hybridization (fish) assay to enable more accurate integration of codex and single-nuclei data. The resultant three- dimensional maps will span all layers of the bowel wall and include the epithelial, enteroendocrine, vascular, lymphatic, nervous, immune, and muscular cell populations that contribute to normal bowel function.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $500,000 | |
| Amendment | $200,000 | |
| Amendment | $2,427,714 | |
| Amendment | $2,427,714 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $99,903 | |
| Amendment | $89,913 | |
| Amendment | $2,218,382 | |
| Amendment | $2,218,382 | |
| Amendment | $1,999,996 | |
| Original award | $1,999,996 |
Show all 13
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Native Bio-Data Consortium | $11,183 | |
| The Washington University | $35,421 | |
| The Washington University | $178,895 | |
| Native Bio-Data Consortium | $81,720 | |
| University Of Washington | $8,421 | |
| President And Fellows Of Harvard College | $228,289 | |
| Native Bio-Data Consortium | $84,582 |
Quick answers
Who received award U54HG012723?
U54HG012723 was awarded to The Leland Stanford Junior University by National Human Genome Research Institute (National Institutes of Health) on September 23, 2022.
How much is award U54HG012723 worth?
$14,182,000 has been obligated on U54HG012723.
Which agency awarded U54HG012723?
National Human Genome Research Institute (National Institutes of Health) awarded U54HG012723, with funding from Office of the Director (National Institutes of Health).
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