Cooperative Agreement U44TR004958
- The Tiny Cargo Company received a $432,000 National Science Foundation Technology, Innovation, and Partnerships Project Grant to test the scalability of an exosome isolation technology for developing an orally administered radioprotective therapeutic. The goal is to establish proof-of-concept for a safe, orally delivered drug platform capable of transporting biologic and small molecule therapeutics to treat radiation damage and related diseases. The first year of the award will determine scaling...
- Federal Cooperative Agreement Summary The University of Arizona received a $583,468 Cooperative Agreement award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) on September 16, 2025, with an ultimate completion date of August 31, 2030. This award supports the development of a novel medical countermeasure to mitigate accidental ionizing radiation exposure through the advancement of MH01, a small-molecule protein ligand...
- Federal Cooperative Agreement Summary Window Therapeutics, Inc. received a $1.0 million Cooperative Agreement award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) on July 15, 2025. The Small Business Innovation Research (SBIR) Phase II project, with a completion date of June 30, 2027, focuses on developing next-generation antibody-drug conjugates (ADCs) utilizing proprietary brush polymer technology. The core...
- Federal Cooperative Agreement Summary Capture Collective, Inc. received a $449,099 Cooperative Agreement award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) effective May 4, 2026, with a completion date of April 30, 2031. The award funds development and validation of the MIRAD (Micrornas for Radiation Absorbed Dose) assay, a high-throughput, blood-based polymerase chain reaction (PCR) biodosimetry platform...
- Federal Cooperative Agreement Summary Temple University received a $554,674 Cooperative Agreement award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective April 20, 2026, with completion targeted for March 31, 2031. The award supports development of a multiorgan microphysiological platform (RadChip) designed to discover and screen therapeutic candidates for treating radiation-induced vascular injury. The...
- Federal Cooperative Agreement Award Summary The Medical College of Wisconsin, Inc. received a $546,000 Cooperative Agreement award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective August 11, 2025, with a completion date of July 31, 2030. The award supports research and development of medical countermeasures (MCMs) to mitigate the Delayed Effects of Acute Radiation Exposure (DEARE), specifically addressing...
- The federal Project Grant award of $1,851,874.00 was provided by the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) program. The grant supports advanced biomedical research initiatives focused on transforming healthcare for military service members and the broader public, with a particular emphasis on conditions relevant to military personnel and veterans. The primary awardee, The Henry M. Jackson Foundation for the Advancement of Military Medicine,...
- Federal Cooperative Agreement Summary Rattan Life Science Inc. received a $1.25 million Cooperative Agreement from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) awarded June 1, 2025, with an expected completion date of May 31, 2027. The company will develop and validate a proprietary platform technology for scalable production of induced naïve T cells derived from induced pluripotent stem cells (iPSCs) and iPSC-derived thymic...
- Federal Cooperative Agreement Summary Duke University's Office of Research Administration received a $536,817 Cooperative Agreement awarded on August 11, 2025, by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) to advance research on thioredoxin derivatives for radiation mitigation. The award supports development of ORP100S, a pharmacologically optimized engineered version of the human stress-protectant protein...
- Federal Cooperative Agreement Summary The University of Pittsburgh received a $547,537 Cooperative Agreement from the National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective September 19, 2025, through August 31, 2030. This award supports research to develop medical countermeasures for mitigating hematopoietic acute radiation syndrome (H-ARS), a severe condition resulting from total body irradiation. The project focuses on...
The Tiny Cargo Company received a $985,974 Cooperative Agreement from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) awarded July 1, 2026, with completion targeted for June 30, 2028. Under this award, the company is developing Xolacta, a therapeutic comprised of milk-derived extracellular vesicles (MEVs) loaded with a regenerative drug designed to protect gastrointestinal tract and bone marrow tissue following high-dose ionizing radiation exposure. The company is pursuing FDA regulatory approval under the Animal Rule to establish Xolacta as both a radiotherapeutic medical countermeasure for radiation exposure and as a dual-use adjuvant therapy for patients undergoing radiation cancer treatment, with the U.S. Strategic National Stockpile identified as the initial customer through the BARDA BlueKnight program. The funding supports the company's efforts to advance its proprietary milk-derived extracellular vesicle platform technology, which includes methods for industrial purification of MEVs from milk, drug loading techniques, non-cold chain storage solutions, and enhanced tissue targeting capabilities. Beyond Xolacta, the platform has potential applications for oral systemic delivery of other therapeutic and nutraceutical molecules. The company has demonstrated promising preclinical results, including greater than 40 percent survival improvement in mice following lethal radiation exposure using orally administered Xolacta.Federal Cooperative Agreement Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $986.0k | 6/23/26 |