University of washington (UW) mendelian genomics data coordinating center
Active Cooperative Agreement Awarded Last action
- Award ID
- U24HG011746
- Recipient
-
University Of Washington UEI HD1WMN6945W6
- Awarding agency
-
National Human Genome Research Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $34,074,666
Award facts
- Assistance listing
- 93.172 Human Genome Research
- Completion date 93% complete
- Originally
- Funding
-
- $31,878,791.00 Federal
- $2,195,875.00 Non-federal
- Place of performance
- Seattle, WA 98195, USA
Award details come from USAspending.gov.
Description
- Abstract
- Despite significant advances made in understanding the genetic basis of the more than 10,000 estimated mendelian conditions in recent decades, further scientific collaboration and discovery is required to identify the full set of mendelian diseases and their underlying genetic causes. To build on the success of the centers for mendelian genomics by using further technological, methodological, and data-sharing innovations, nhgri is establishing a new mendelian genomics research consortium. As data coordinating center for this consortium, we propose to further the discovery and characterization of mendelian conditions by achieving four main aims. (1) managing the release of molecular and phenotypic data generated or collected by the consortium's research centers, featuring semi-automated and scalable quality control procedures that will validate incoming data against collaboratively-established standards and requirements. We will facilitate data sharing within the consortium and the broader scientific community by ensuring that curated data are submitted to appropriate repositories including anvil, clinvar, and matchmaker exchange. (2) supporting program outreach through a consortium website that highlights program progress and discoveries and enabling connections among researchers, clinicians, and families. We will also oversee education, training, and mentorship opportunities. (3) coordinating logistics for the consortium, including organization of virtual and in-person meetings and administrative support for all consortium-wide activities. (4) overseeing an opportunity fund, administering up to 5 awards in each of years 2-5 of the consortium, to support novel and scalable approaches to functional follow-up on candidate variants. To achieve these four main aims, we propose innovative approaches, including leveraging emerging cloud-based systems for the storage and analysis of human genetic data and integrating international data sharing standards to ensure that data is findable, accessible, interoperable, and reusable (FAIR). Furthermore, we bring a unique blend of expertise across the fields of data science, cloud systems, biostatistics, bioethics, clinical genetics, and mendelian discovery to the consortium, and our application rests on 13 successful years of experience and expertise serving as coordinating or analysis centers for 7 large-scale genetic and biomedical projects. Through support and coordination of this consortium, we will help yield the benefits of identifying the genetic basis of mendelian conditions to support diagnosis, therapy, and further delineation of syndromes. Further public health benefit will accrue via biological insights into mendelian diseases that also advance our understanding of related common, complex diseases.
Transactions
| Action | Federal | Non-federal | Date |
|---|---|---|---|
| Amendment | $0 | $0 | |
| Amendment | $1,279,092 | $0 | |
| Amendment | $1,279,092 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $2,714,093 | $0 | |
| Amendment | $2,714,093 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $225,495 | $0 | |
| Amendment | $225,495 | $0 | |
| Amendment | $225,495 | $0 | |
| Amendment | $2,536,785 | $0 | |
| Amendment | $2,536,785 | $0 | |
| Amendment | $2,536,785 | $0 | |
| Amendment | $2,536,785 | $0 | |
| Amendment | $2,866,502 | $0 | |
| Amendment | $2,866,502 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $2,944,042 | $0 | |
| Amendment | -$16,473 | $0 | |
| Amendment | -$16,473 | -$16,473 | |
| Amendment | $2,212,348 | $0 | |
| Original award | $2,212,348 | $2,212,348 |
Show all 28
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Pacific Northwest Research Institute | $227,963 | |
| University Of Massachusetts Medical School | $205,173 | |
| Research Institute At Nationwide Children's Hospital | $395,676 | |
| Childrens Mercy Hospital | $128,438 | |
| Massachusetts Eye And Ear Infirmary | $17,000 | |
| The Broad Institute, Inc. | $9,041 | |
| Research Institute At Nationwide Children's Hospital | $16,700 | |
| Pacific Northwest Research Institute | $18,179 | |
| University Of Massachusetts Medical School | $16,744 | |
| The University Of Chicago | $134,998 | |
| New York University | $83,903 | |
| Massachusetts Eye And Ear Infirmary | $403,750 | |
| The Broad Institute, Inc. | $101,711 | |
| Research Institute At Nationwide Children's Hospital | $187,876 | |
| University Of Massachusetts Medical School | $188,424 | |
| Pacific Northwest Research Institute | $204,506 | |
| The Broad Institute, Inc. | $107,725 | |
| New York University | $93,225 |
Show all 18
Quick answers
Who received award U24HG011746?
U24HG011746 was awarded to University Of Washington by National Human Genome Research Institute (National Institutes of Health) on June 1, 2021.
How much is award U24HG011746 worth?
$34,074,666 has been obligated on U24HG011746: $31,878,791 in federal funding and $2,195,875 in non-federal funding.
On GovTribe
See this award's full record
- Every transaction and subaward
- The recipient's other awards and teaming partners
- Similar grant awards
- Ask GovTribe AI about this award