Extending the capabilities and reach of emerse in support of cancer research

Active Cooperative Agreement Awarded Last action

Award ID
U24CA269315
Recipient
Awarding agency
Obligated
$4,565,773

Award facts

Assistance listing
93.393 Cancer Cause and Prevention Research
Completion date 63% complete
Place of performance
Ann Arbor, MI 48108, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The free text notes in electronic health records (EHRS) contain details vital to cancer research that often are found nowhere else in the EHR. Such details include social and behavioral determinants of health, family histories, cancer staging, tumor markers, disease progression, response to treatment, overall outcomes, and more. Utilizing the free text (also called unstructured data) can be challenging, and researchers need tools to help them leverage those data in a meaningful way. The electronic medical record search engine (EMERSE) has been in operation, and under continuous development, for 17 years and was designed to help cancer researchers meaningfully use unstructured EHR data. EMERSE started as simple information retrieval system but has since gained many features for supporting clinical research. IT is distinguished from other text-processing research tools, in part, by its ease of use and other enterprise software features such as maintaining audit logs and providing administrator functions. With the support of an itcr grant that is nearing completion, EMERSE has grown from a tool used at only one site (university of michigan) to one that is running, or being implemented, at multiple cancer centers and other academic research institutions across the country. EMERSE also now supports the capability of searching across a network of instances to securely obtain obfuscated patient counts at other sites, which can be valuable for identifying rare cancer cohorts. The innovations in this proposal include: (1) building new functionality into EMERSE to expand its research capabilities such as timeline data visualizations, self-service data extraction workflows from templated notes, support for optical character recognition (OCR), and integration with other itcr tools such as deepphe through an application programming interface (API); (2) incorporating natural language processing (NLP) into EMERSE including named entity recognition (mapped to the unified medical language system, umls), negation (e.g., "patient denies pain"), uncertainty (e.g., "possibility of recurrence"), and experiencer (E.G, "breast cancer in her mother"); (3) expanding the EMERSE network in breadth, capability, security, and trust by partnering with external sites to collectively develop a consensus and a viable approach for broadly enabling this novel network technology; and (4) continuing to evaluate EMERSE with a focus on networking, security, and scientific outcomes by conducting additional user-centered studies to develop a deeper understanding of how EMERSE is being, or could be, used with a goal of continuous improvement. The EMERSE team routinely receives feedback from users and site administrators and the proposed work is highly responsive to our growing user base and will enable research that is currently impractical, if not impossible, for many researchers to accomplish. The enhancements and knowledge gained from this effort will make EMERSE even more powerful and capable of supporting a wide range of clinical and translational cancer research for a growing user base across the nation.

Transactions

Action Obligated Date
Amendment $750,711
Amendment $654,861
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $767,904
Amendment $767,904
Amendment $767,904
Original award $856,489
Show all 12

Subawards

Subrecipient Amount Awarded
The Children's Hospital Corporation Boston Children’s Hospital will work with the EMERSE team on approaches for integrating their respective NLP tool into EMERSE as an “add on” if an… $36,501
The Regents Of The University Of California. San Francisco University of California - San Francisco will work closely with the EMERSE team to implement locally developed natural language processing algorithms, and… $49,257
H. Lee Moffitt Cancer Center And Research Institute Hospital, Inc. Moffitt Cancer Center will work closely with the EMERSE team to implement locally developed natural language processing algorithms, and ensure that the approach… $67,063
Cincinnati Univ Of University of Cincinnati will participate in the network capabilities offered by EMERSE. University of Cincinnati will work with UM and other participating… $33,412
Rector & Visitors Of The University Of Virginia University of Virginia will participate in the network capabilities offered by EMERSE. University of Virginia will work with UM and other participating sites to… $33,309
University Of Pittsburgh - Of The Commonwealth System Of Higher Education EMERSE STATEMENT OF WORK: DeepPhe Collaboration The DeepPhe team will work closely with the EMERSE team to provide a detailed transfer of technical knowledge… $32,795
The Trustees Of Columbia University In The City Of New York Columbia University will participate in the network capabilities offered by EMERSE. Columbia University will work with UM and other participating sites to… $33,928
University Of California Irvine EMERSE STATEMENT OF WORK: Evaluation UCI will lead the evaluation component of the grant, in partnership with the University of Michigan EMERSE team and other… $115,870

Quick answers

Who received award U24CA269315?

U24CA269315 was awarded to Regents Of The University Of Michigan by National Cancer Institute (National Institutes of Health) on September 15, 2023.

How much is award U24CA269315 worth?

$4,565,773 has been obligated on U24CA269315.

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