Cooperative Agreement U24AG056270

The National Institute on Aging (NIA) awarded a $312,000 Project Grant under the Aging Research federal grant program (CFDA 93.866) to The Medical College of Wisconsin, Inc. The objective of this 2-year project is to investigate the impact of late-onset Alzheimer's disease (LOAD)-associated genes on neurodegeneration and Alzheimer's disease-related neurotoxicity using C. elegans as a model system. The research aims to enhance understanding of the genetic basis of Alzheimer's disease by...

This Project Grant award of $170,604 from the National Institute on Aging (CFDA 93.866 Aging Research) aims to investigate the role of the LRFN2 gene as a potential neuroprotective factor against Alzheimer's disease-related cortical neurodegeneration. The awardee, The Jackson Laboratory, a nonprofit biomedical research institution, will develop a novel LRFN2 overexpression transgenic mouse model and evaluate the impact of LRFN2 expression on disease progression in the 5XFAD Alzheimer's mouse...

This $788,121 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) will fund a 5-year cross-sectional, longitudinal, and observational study to investigate the impact of Alzheimer's disease (AD) risk genes, with a focus on APOE E4, on brain function in HIV-positive older Black/African American adults. The study aims to increase understanding of Alzheimer's disease and related dementias (ADRD) risk factors in this vulnerable population, who face an increased...

The National Institute on Aging (NIA) awarded a $459,250 Project Grant (CFDA 93.866 - Aging Research) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to investigate and validate the use of dried blood spot (DBS) samples for measuring Alzheimer's disease (AD) biomarkers. The key objectives are to: 1) optimize fingerstick collection methods and validate assays for three key AD biomarkers (pTau217, GFAP, and NFL) in DBS samples; 2) establish if DBS...

The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), has awarded a $429,000 project grant to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, to support research on the role of Alzheimer's disease risk genes in neural function, degeneration, and synapse organization. The project aims to examine how specific mutations in the PSEN1 gene, which are linked to early-onset familial Alzheimer's disease, influence adult...

This three-year, $4,349,236 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The University of South Florida will investigate the role of the BIN1 gene in modulating Alzheimer's disease tau neuropathology in vivo. Researchers will generate cell-type specific inducible BIN1 knockout mice to characterize tau pathogenesis using longitudinal MRI and neuropathology. They will test...

The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $770,558 project grant to Wake Forest University Health Sciences (WFUHS) to establish connections between Alzheimer's disease (AD)-related genomic markers and neuroimaging phenotypes. The objective is to determine the heterogeneity of AD subtypes and their association with the clinical onset of dementia. The project aims to develop data-driven computational models using multi-modal...

The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $245,434 project grant to Wake Forest University Health Sciences (WFUHS) to examine the associations between early and later-life stress on later-life cognition and plasma biomarkers of Alzheimer's disease and related dementias (ADRD). The study aims to investigate how stress experienced across the lifespan, as well as perceived psychological stress, may impact cognitive decline and...

The National Institute on Aging (NIA), through its Aging Research federal grant program (CFDA 93.866), awarded a $630,496 project grant to the J. David Gladstone Institutes to conduct research on proteostasis, neuroinflammation, and neurodegeneration in frontotemporal dementia (FTD). The research aims to better understand how GRN haploinsufficiency, a key genetic factor in FTD, impairs the autophagy/lysosomal pathway and ubiquitin proteasome system, leading to accumulation of toxic proteins,...

The National Institute on Aging (NIA) awarded a $422,125 Project Grant under the Aging Research program (CFDA 93.866) to the University of Miami Office of Research Administration - School of Medicine Division. The 2-year grant, effective September 1, 2023, will investigate the relationship between loss of the Y chromosome (LOY) and Alzheimer's disease (AD) pathogenesis. The project aims to 1) examine whole-blood transcriptomic changes in LOY+ individuals, and 2) determine differences in immune...