Cooperative Agreement U01NS142100
- The Allen Institute was awarded a $2,500,000 Cooperative Agreement by the National Institute of Neurological Disorders and Stroke (NINDS) under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). The award funds the Integrative Connectomics Coordination Center (IC3), which will work closely with BRAIN Connects data generation teams to develop and harmonize common data processing pipelines for cutting-edge connectomics...
- This Cooperative Agreement award from the National Institute of Neurological Disorders and Stroke (NINDS) under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372) provides $347,874 to the Allen Institute to develop a new large-scale light-sheet (LS2) microscope. This advanced microscopy system enables high-resolution, high-contrast, and high-speed imaging of centimeter-scale biological tissue volumes, overcoming the...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $4,095,511 Cooperative Agreement under the "21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative" (CFDA 93.372) to The Children's Hospital Corporation (doing business as Boston Children's Hospital). The funding will support the development of a high-throughput brain connectomics solution by integrating automated section collection and handling with advanced...
- This $1,009,658 Cooperative Agreement award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), supports the development of advanced X-ray nanotomography methods for high-resolution 3D brain tissue imaging at the European Synchrotron Research Facility (ESRF) in the United Kingdom. The project aims to leverage the enhanced coherent X-ray...
- The National Institute of Neurological Disorders and Stroke (NINDS) has awarded a $784,479 Cooperative Agreement to the University of California, Los Angeles (UCLA) under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative program (CFDA 93.372). The funding will support efforts to further strengthen and expand the open-source UCLA Miniscope ecosystem, a widely adopted platform for innovative neural and behavioral imaging technologies in...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Trustees of Columbia University in the City of New York, doing business as the Health Sciences Division, a $2,554,313 federal Project Grant under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). The grant, which runs from Sep 1, 2023 to Aug 31, 2026, will support research to determine if targeted in vivo manipulations of local circuit control...
- The National Institutes of Health (NIH) Office of the Director awarded a $1,271,280 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Allen Institute in Seattle, WA. The award, spanning September 2024 to September 2027, aims to develop two "exa-scale" (extremely high-throughput) tissue readout methods to transform the study of the brain. The first method will enable highly multiplexed molecular mapping of individual proteins across entire brains at the...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $2,724,344 Project Grant under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative to the Massachusetts Institute of Technology (MIT). The grant, awarded on August 1, 2025, supports the development of two new high-speed image sensor technologies: A 600 x 800 pixel sensor with 1 kHz temporal resolution for fluorescence micro-endoscopy in freely moving mice. A 600...
- The National Institutes of Health National Institute of Neurological Disorders and Stroke awarded $1,852,675 under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies program (CFDA 93.372) to the University of California, Los Angeles from August 1, 2022 to July 31, 2025. The award will support the development of light field tomographic microscopy for kilohertz volumetric imaging of neuronal action potentials in awake behaving mice. Specifically, the...
- This Cooperative Agreement award of $718,052 from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, CFDA 93.372, aims to study the interplay between language and cognition. The project will leverage high-density laminar array recordings in the operating room, single-cell genomic/spatial transcriptomic analyses, laminar fMRI, and computational modeling to...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $2,039,359 Cooperative Agreement under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372) to the Allen Institute. The award, titled "BRAIN CONNECTS: LIGHT MICROSCOPY FOR CELL-TYPE SPECIFIC MESOSCALE TO NANOSCALE DENSE CONNECTOMICS," aims to leverage light microscopy-based connectomics (LICONN) and electron microscopy data to create molecularly informed cell type connectivity patterns across multiple scales of the mammalian brain. The key objectives are to: 1) integrate LICONN with large-scale electron microscopy data to establish links between molecular and connectivity cell types, 2) combine LICONN with mesoscale expansion microscopy to map microscale connectivity in gray matter and link it to white matter connections, and 3) test the feasibility of expanding LICONN to larger volumes and scaling nanoscale expansion microscopy. This award supports the BRAIN Initiative's goals of revolutionizing our understanding of the brain through innovative neurotechnology development.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $183.5k | 9/12/25 | ||
| Not listed | $1.9m | 8/11/25 |