Cooperative Agreement U01EB021236

Molecular Instruments, Inc. received a $306,788 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for the period September 30, 2025 through September 29, 2026. The award supports the development and advancement of probe technology for ultrasensitive RNA imaging utilizing Hybridization Chain Reaction (HCR) methodology. The company is developing enhanced in situ amplification-based imaging...

This $1,399,500 Project Grant award from the National Institutes of Health's Trans-NIH Research Support program (CFDA 93.310) will fund research at the University of Wisconsin - Madison to develop "cellular radio" circuits that can be used to visualize, probe, and perturb the dynamic protein activity in individual cells. The project aims to create genetically-engineered circuits that generate a frequency-modulated, barcoded fluorescent signal to track how the internal state of cells...

The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $669,456 Project Grant to the University of Chicago under the Biological Sciences program (CFDA 47.074) for the project "Collaborative Research: Tools 4 Cells: Developing Next Generation Methods for Studying Cytoskeletal Factors in the Cell Nucleus". This 3-year project aims to develop novel tools to precisely perturb and study the role of the cytoskeletal protein actin within the cell...

The National Science Foundation (NSF) awarded a $300,000 Project Grant under its Biological Sciences program (CFDA 47.074) to the Georgia TECH Research Corporation for the "TOOLS4CELLS: EAGER: A MOLECULAR PURSUIT FOR THE ENGRAM: MICROFLUIDIC TEMPORAL TRANSCRIPTOMICS FOR SINGLE CELL LEARNING" project. This 2-year effort aims to develop innovative microfluidic tools and workflows to investigate the role of non-coding RNA in learning and memory storage in single-celled organisms. Key...

This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $500,000 in funding to The Regents of the University of Colorado to develop a suite of fluorescent RNA-based biosensors for monitoring metabolites in the methionine cycle of one-carbon metabolism in live cells. The project aims to create a "plug-and-play" toolkit of biosensors that can be used to study the dynamics and flux of central metabolites involved in regulating...

The Center for Open Bioimage Analysis, funded by the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), received a $728,992 Project Grant award effective September 1, 2025 through August 31, 2030. Administered through the University of Wisconsin–Madison in collaboration with the Cimini Laboratory at the Broad Institute, the Center consolidates two widely-used open-source bioimage analysis platforms—ImageJ (including ImageJ2...

Federal Project Grant Award Summary Stanford University received a $462,119 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 8, 2025, with completion targeted for July 31, 2029. The award funds development and deployment of Transposon Accelerated Chromatin Kinetic Imaging Technology (TRACK-IT), a next-generation live-imaging platform designed to map...

This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) will provide $649,999 to Northwestern University to develop a new label-free nanoimaging platform called 3D DNA Spectroscopic Photon-Localization Intrinsic-Contrast Nanoscopy (3D DNA-SPIN). The goal is to image the genome of intact fixed cells in 3D with 2-nanometer resolution, providing chemical and molecular information without the need for fluorescent labels. The project aims to 1) develop...

This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...

This $769,749 Project Grant from the National Institutes of Health's National Institute of General Medical Sciences will support the development of Fluorescence Enhanced Photothermal Infrared Spectroscopy (FE-PTIR) technology by Photothermal Spectroscopy Corp. The FE-PTIR technique aims to provide simultaneous fluorescence microscopy and sub-micron infrared spectroscopy to map the distribution of fluorescently labeled biomolecules within cells and tissues while also analyzing their chemical...