This federal Project Grant award of $430,375.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research by Emory University to investigate neurogenic defects in cellular models of Fragile X Syndrome. The project aims to determine if cyclic AMP signaling is disrupted during early brain development in Fragile X Syndrome and whether targeting the microtubule-associated protein Doublecortin could have therapeutic...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $2,049,254 to Cold Spring Harbor Laboratory to investigate the role of transient neuronal connectivity in the development and maturation of cortical circuits, and its implications for the treatment of Fragile X Syndrome. The research aims to elucidate the mechanisms by which sensory and neuromodulatory inputs establish transient connections with...
The National Institute of Child Health and Human Development (NICHD) awarded a $267,310 project grant to The Trustees of the University of Pennsylvania under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant, awarded on August 10, 2024, will support a research project to investigate the mechanisms by which the mutation-length CGG short tandem repeat in the FMR1 gene coordinates megabase-scale heterochromatin domains and their inter-chromosomal...
The University of South Carolina was awarded a $210,310 Project Grant by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant, with a start date of August 1, 2024 and end date of January 31, 2027, will fund a study examining maternal-child respiratory sinus arrhythmia (RSA) synchrony in 12-month-old male infants with Fragile X Syndrome (FXS) compared to neurotypical controls. The project...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $509,310.95 to the University of Texas at Austin to conduct a longitudinal study on depression and social-emotional factors in adolescent girls with autism spectrum disorder (ASD). The key objectives are to: 1) map trajectories of depression symptoms in girls with ASD and typical development from ages 10-13 using longitudinal structural equation...
The Washington University Office of Sponsored Research Services Division received a $427,625 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research to unravel the role of satellite glial cells in sensory hypersensitivity in Fragile X Syndrome, a leading genetic cause of autism spectrum disorders. Key activities include: Examining how...
This $727,160 Project Grant award from the National Institute of Child Health and Human Development's Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to characterize early cognitive growth and identify biomedical factors associated with severe or profound intellectual disability in children with Down syndrome. The project will recruit 90 children with Down syndrome to undergo comprehensive cognitive and developmental assessments over 3 annual waves,...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $443,121.00 to the University of California, Santa Cruz (UCSC) to leverage innovative in situ cryo-electron microscopy (cryo-EM) techniques to study dysregulated protein synthesis, or translation, in an autism spectrum disorder (ASD) model. The key objectives are to: 1) Develop a...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $690,110 to the Children's Hospital Medical Center in Cincinnati, Ohio to conduct a randomized clinical trial of the "Achieving Independence & Mastery in School (AIMS)" intervention for middle-school students with autism spectrum disorder (ASD). The study aims to examine the...
This Project Grant award of $431,750 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to investigate the molecular mechanisms underlying sex-specific deficits in neurodevelopmental disorders, with a focus on autism spectrum disorder (ASD). The research, conducted by Rutgers, The State University of New Jersey, utilizes mouse models with Coiled-Coil and C2 Domain Containing 1A (CC2D1A) gene deficiency to examine...