12/24 healthy brain and child development national consortium
Active Cooperative Agreement Awarded Last action
- Award ID
- U01DA055363
- Recipient
-
Oregon Health & Science University UEI NPSNT86JKN51
- Awarding agency
-
National Institute on Drug Abuse
National Institutes of Health, Department of Health and Human Services
- Obligated
- $29,949,825
Award facts
- Assistance listing
- 93.865 Child Health and Human Development Extramural Research
- Completion date 88% complete
- Originally
- Funding
-
- $28,934,636.00 Federal
- $1,015,189.00 Non-federal
- Funding agency
- National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services
- Place of performance
- Portland, OR 97239, USA
Award details come from USAspending.gov.
Description
- Abstract
- Neurodevelopmental processes are shaped by dynamic interactions between genes and environments. Maladaptive experiences early in life can alter developmental trajectories, leading to harmful and enduring developmental sequelae. Pre- and postnatal hazards include maternal substance exposure, toxicant exposures in pregnancy and early life, maternal health conditions, parental psychopathology, maltreatment, structural racism, and excessive stress. To elucidate how various environmental hazards impact child development, IT is imperative that a normative template of developmental trajectories over the first 10 years of life be established based on a sufficiently large and demographically diverse sample of the US population. To accomplish this, the healthy brain and child development national consortium (hbcd-NC) has been formed to deploy a harmonized, optimized, and innovative set of neuroimaging (MRI, EEG) measures complemented by an extensive battery of behavioral, physiological, and psychological tools, and biospecimens to understand neurodevelopmental trajectories in a sample of 7,500 mothers and infants enrolled at 24 sites across the united states (US). The hbcd-NC will carry out a common research protocol under direction of the hbcd- NC administrative core (hcac) and will assemble and distribute a comprehensive and well-curated research dataset to the scientific community at large under the direction of the hbcd-NC data coordinating center (hdcc). The overarching goal of the hbcd-NC is to create a comprehensive, harmonized, and high- dimensional dataset that will characterize typical neurodevelopmental trajectories in US children and that will assess how biological and environmental exposures affect those trajectories. A special emphasis will be placed on understanding the impact of pre- and postnatal exposure to opioids, marijuana, alcohol, tobacco and/or other substances. To address these broad objectives, the sample of women enrolled will include: 1) a racially, ethnically, and socioeconomically diverse cohort that is representative of the US population; 2) pregnant woman with use of targeted substances (opioids, marijuana, alcohol, tobacco); and 3) demographically and behaviorally similar women without substance use in pregnancy to enable valid causal inferences. In addition, the hbcd-NC will identify key developmental windows during which both harmful and protective environments have the most influence on later neurodevelopmental outcomes. The large, multi- modal, longitudinal, and generalizable dataset that will be produced for the first time by this study will provide novel insights into child development using state-of-the-art methods. The hbcd-NC study will inform public policy to improve the health and development of children across the nation.
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Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Coda, Inc. | $50,022 |
Quick answers
Who received award U01DA055363?
U01DA055363 was awarded to Oregon Health & Science University by National Institute on Drug Abuse (National Institutes of Health) on September 30, 2021.
How much is award U01DA055363 worth?
$29,949,825 has been obligated on U01DA055363: $28,934,636 in federal funding and $1,015,189 in non-federal funding.
Which agency awarded U01DA055363?
National Institute on Drug Abuse (National Institutes of Health) awarded U01DA055363, with funding from National Institute of Child Health and Human Development (National Institutes of Health).
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