Population modeling of bladder cancer detection and control

Ended Cooperative Agreement Awarded Last action

Award ID
U01CA265750
Recipient
Awarding agency
Obligated
$8,101,242

Award facts

Assistance listing
93.393 Cancer Cause and Prevention Research
Completion date
Funding
  • $6,739,357.00 Federal
  • $1,361,885.00 Non-federal
Place of performance
Providence, RI 02903, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Bladder cancer is the second most common genitourinary malignancy in the US with approximately 80,000 new cases and 17,700 deaths each year. IT is a heterogeneous set of diseases that range from locally treatable superficial tumors that are generally not life-threatening but require chronic management, to advanced disease that requires multimodal invasive treatments and has higher risk of distal metastasis and death. IT is the ninth most expensive cancer overall in the US, and, per diagnosed patient, the most expensive cancer to manage. Risk factors for bladder cancer broadly include chemical and environmental exposures such as cigarette smoking and chemical carcinogens that are ingested or found in the workplace, as well as genetic abnormalities and chronic bladder irritation. Outcomes for bladder cancer have remained relatively stable in the last two decades. However, opportunities abound to improve the prevention, detection, and management of bladder cancer. The advent of novel biomarkers, and novel treatments, including immunotherapies (checkpoint inhibitors), gene therapies, and antibody-drug conjugates may have a large impact in coming years. Bladder cancer is amenable to population modeling because IT has high morbidity, mortality, and cost, is likely preventable by minimizing smoking and toxin exposure, and the emergence of novel promising biomarkers and treatments. The long-term goal of our research program is to improve the effectiveness and efficiency of population- and person-level approaches to bladder cancer prevention, detection, and management given current knowledge and constraints. The overall objective of the current proposal is to address major questions in the surveillance, treatment, prevention, and diagnosis of bladder cancer by means of comparative mathematical modeling. We will address six specific aims: we will (1) complete the development, calibration, and validation of two independent population models of bladder cancer; (2) explain secular trends in bladder cancer incidence in relation to trends in tobacco use in key population subgroups and estimate the impact of the 1964 surgeon general's smoking recommendations; (3) assess the effectiveness of smoking cessation, reduction and prevention interventions for the prevention of bladder cancer incidence and mortality; (4) assess the effectiveness and cost-effectiveness of generic and tailored/patient-centric surveillance policies for patients with non-muscle invasive bladder cancer; (5) assess the comparative effectiveness of treatments for organ-confined bladder cancer; and (6) assess the effectiveness of screening for bladder cancer among high-risk subgroups.

Transactions

Action Federal Non-federal Date
Amendment $67,752 $0
Amendment $699,128 $0
Amendment $633,411 $0
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Amendment $653,602 $0
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Amendment $654,490 $0
Amendment $654,490 $654,490
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Amendment $707,395 $0
Original award $707,395 $707,395
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Subawards

Subrecipient Amount Awarded
The Institute For Cancer Research Subrecipient PI will be responsible for the overall coordination and biostatistical support of the proposed research activities at Fox Chase Cancer Center… $39,101
University Of Pittsburgh - Of The Commonwealth System Of Higher Education The Subrecipient PI will assist in the bladder cancer model conceptualization and developments. Advise the COBRAS team to conceptualize the natural history of… $55,650
The Leland Stanford Junior University The Subrecipient PI will collaborate with PI to: Aim 1 (Year 1): Develop, calibrate, and validate the mathematical model;Aim 2 (Years 1 and 2): Explain… $57,067
Tufts Medical Center Parent, Inc. For the Modeling Group (model B), the Subrecipient PI will advise the PI on clinical and technical issues and the planning and analysis of research, and will… $21,224
Tufts Medical Center Parent, Inc. For the Coordinating Center, the Subrecipient will advise and aid the PI on identifying, prioritizing, and refining policy and clinical questions and new… $21,224
Regents Of The University Of Minnesota The University of Minnesota team will collaborate with the COBRAS (Cancer Of Bladder R Analytic Simulator) modeling group under the direction of the… $66,536
University Of Ottawa Subrecipient PI with the other team members has started the independent model conceptualization of the natural history model of bladder cancer in September 2020… $67,752
University Of Ottawa Dr. Hawre Jalal will work closely with the other members of the team including Dr. Karen Kuntz (University of Minnesota), Dr. Fernando Alarid-Escudero (Stanford… $34,273
University Of Pittsburgh - Of The Commonwealth System Of Higher Education Dr. Bruce Jacobs will assist in the bladder cancer model conceptualization and developments. Advise the COBRAS team to conceptualize the natural history of… $61,359
The Leland Stanford Junior University Dr. Fernando Alarid Escudero, will be part of the COBRAS (Cancer of Bladder R Analytic Simulator) modeling group under the direction of Dr. Hawre Jalal at the… $50,355
Regents Of The University Of Minnesota The University of Minnesota team will collaborate with the COBRAS (Cancer Of Bladder R Analytic Simulator) modeling group under the direction of Dr. Hawre Jalal… $74,084
Tufts Medical Center Parent, Inc. For the Modeling Group (model B), Dr. Wong will advise PI TA Trikalinos on clinical and technical issues and the planning and analysis of research, and will… $22,078
Tufts Medical Center Parent, Inc. For the Coordinating Center, Dr. Wong will advise and aid PI TA Trikalinos on identifying, prioritizing, and refining policy and clinical questions and new… $22,078
Massachusetts Institute Of Technology Dr. Trichakis will work with the Coordinating Center in project years 1 through 5, and he will advise and aid PI TA Trikalinos on technical issues related to… $18,196
University Of Ottawa Dr. Hawre Jalal is an Associate Professor at the School of Epidemiology and Public Health at the University of Ottawa, Faculty of Medicine. As a multi-PI, he… $68,236
University Of Pittsburgh - Of The Commonwealth System Of Higher Education The project will allow Dr. Kumar to work independently on a project under the mentorship of Dr.Hawre Jalal and Dr. Thomas Trikalinos. The work will add to his… $32,666
The Leland Stanford Junior University Dr. Fernando Alarid Escudero, will be part of the COBRAS (Cancer of Bladder R Analytic Simulator) modeling group under the direction of Dr. Hawre Jalal at the… $13,496
Consorcio De Investigacion Sobre VIH Sida TB Cisidat, A.C. We are currently developing a method to sample time-to-events from NHPPP by assuming the time-to-event is drawn from a categorical distribution in which each… $12,999
University Of Ottawa Dr. Hawre Jalal is an Associate Professor at the School of Epidemiology and Public Health at the University of Ottawa, Faculty of Medicine. As a multi-PI, he… $0
University Of Pittsburgh - Of The Commonwealth System Of Higher Education As an Assistant Professor in the Department of Urology and Associate Program Director of the Urologic Oncology Fellowship at the University of Pittsburgh. For… $64,589
The Leland Stanford Junior University Dr. Fernando Alarid Escudero, will be part of the COBRAS (Cancer of Bladder R Analytic Simulator) modeling group under the direction of Dr. Hawre Jalal at the… $39,510
Regents Of The University Of Minnesota The University of Minnesota team will collaborate with the COBRAS (Cancer Of Bladder R Analytic Simulator) modeling group under the direction of Dr. Hawre Jalal… $64,985
Massachusetts Institute Of Technology Dr. Trichakis will work with the Coordinating Center in project years 1 through 5, and he will advise and aid PI TA Trikalinos on technical issues related to… $19,155
Tufts Medical Center Parent, Inc. For the Coordinating Center, Dr. Wong will advise and aid PI TA Trikalinos on identifying, prioritizing, and refining policy and clinical questions and new… $14,154
Tufts Medical Center Parent, Inc. For the Modeling Group (model B), Dr. Wong will advise PI TA Trikalinos on clinical and technical issues and the planning and analysis of research, and will… $23,759
University Of Ottawa Dr. Hawre Jalal is an Associate Professor at the School of Epidemiology and Public Health at the University of Ottawa, Faculty of Medicine. As a multi-PI, he… $0
University Of Pittsburgh - Of The Commonwealth System Of Higher Education As an Assistant Professor in the Department of Urology and Associate Program Director of the Urologic Oncology Fellowship at the University of Pittsburgh. For… $91,278
Regents Of The University Of Minnesota The University of Minnesota team will collaborate with the COBRAS (Cancer Of Bladder R Analytic simulator) modeling group under the direction of Dr. Hawre Jalal… $88,630
Tufts Medical Center Parent, Inc. For the Coordinating Center, Dr. Wong will advise and aid PI TA Trikalinos on identifying, prioritizing, and refining policy and clinical questions and new… $43,612
Tufts Medical Center Parent, Inc. For the Modeling Group (model B), Dr. Wong will advise PI TA Trikalinos on clinical and technical issues and the planning and analysis of research, and will… $40,587
University Of Ottawa Dr. Hawre Jalal is an Associate Professor at the School of Epidemiology and Public Health at the University of Ottawa, Faculty of Medicine. As a multi-PI, he… $58,188
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Quick answers

Who received award U01CA265750?

U01CA265750 was awarded to Brown University by National Cancer Institute (National Institutes of Health) on September 13, 2021.

How much is award U01CA265750 worth?

$8,101,242 has been obligated on U01CA265750: $6,739,357 in federal funding and $1,361,885 in non-federal funding.

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