Cooperative Agreement NU51IP000921

MAINTENANCE CAMBODIA?S INFLUENZA SURVEILLANCE NETWORKS AND RESPONSE TO SEASONAL AND PANDEMIC INFLUENZA - CAMBODIA REPORTED 56 HUMAN A/H5N1 CASES WITH 37 DEATHS, PARTICULARLY THE HIGHEST NUMBER OF H5N1 CASES WERE REPORTED IN 2013 AND 2014. IT WAS NOTED THAT H1N1PDM09 INCREASED IN THE FIRST 6 MONTHS IN 2016. ONE BIG OUTBREAK OF H1N1PDM09 WAS REPORTED IN PREY VENG PROVINCE, THAT SHARE BORDER TO VIETNAM. A VERY SEVERE CASE OF H1N1PDM09 WAS DETECTED IN A MAN WHO WORKED AT LOCAL TV STATION. THE CASE WAS ADMITTED IN SARI SENTINEL SITE (KHMER SOVIET HOSPITAL) AND DIED AFTER 7 DAYS OF ONSET. FURTHERMORE, INFLUENZA A/H1N1PDM09 CASES WERE FROM SURVEILLANCE SYSTEM IN CAMBODIA, IN 2020, 150 AND 104 OF A/H1N1PDM09 CASES FROM ILI AND SARI SURVEILLANCES. IN ADDITION, CAMBODIA SEVERAL INFLUENZA A/H3N2 CLUSTERS OUTBREAK DETECTED IN 2020. THERE WERE 305 OF A/H3N2 POSITIVE IN 589 SPECIMENS COLLECTED FROM NINE PRISONS IN COUNTRY. THERE ARE ALSO A/H3N2 CLUSTER OUTBREAK OCCURRED IN CLOSE COMMUNITY, MONASTERY, THERE WERE 111 POSITIVES OF A/H3N2 IN 125 SAMPLES COLLECTED. IN FEBRUARY 2021, FIRST DETECTED HUMAN INFECTION OF INFLUENZA A(H9N2) VIRUS THROUGH ROUTINE INFLUENZA-LIKE ILLNESS SURVEILLANCE IN SIEM REAP. OIE REPORTED, BY 5TH APRIL 2021 THERE WERE SEVERAL OUTBREAKS OF A/H5N1 IN POULTRIES AND WILD BIRD REPORTED, 2255 OF BIRDS HAVE INFECTED, IN VIETNAM REPORTED FIVE OF POULTRIES OUTBREAKS WITH 15,404 POULTRIES INFECTED, AND LAO PDR REPORTED AN OUTBREAK WITH OVER 1,600 POULTRIES INFECTED, THERE WAS NO REPORT FROM THAILAND. UNDER THE FIRST AND SECOND FIVE-YEAR HHS/CDC COOPERATIVE AGREEMENT (COAG), THE NATIONAL INSTITUTE OF PUBLIC HEALTH (NIPH) COOPERATED WITH US CDC TO ESTABLISHED INFLUENZA SURVEILLANCE SYSTEMS TO DETECT AND RESPOND TO SEASONAL, AVIAN, PANDEMIC INFLUENZA, AND OUTBREAKS. FURTHERMORE, THE SYSTEM HAS EXPANDED AND STRENGTHENED LABORATORY AND EPIDEMIOLOGY HUMAN CAPACITY. HOWEVER, GAPS IN SURVEILLANCE CAPACITY REMAIN. THEREFORE, NIPH IS APPLYING FOR ADDITIONAL CDC FUNDING THROUGH THIS NEW 5-YEAR COAG TO HELP TO FILL THESE GAPS AS WELL AS TO MAINTAIN EXISTING SU RVEILLANCE ACTIVITIES. THE GOAL OF THE NEW COAG IS TO MAINTAIN CURRENT INFLUENZA SURVEILLANCE SYSTEM TO DETECT AND RESPOND TO PANDEMIC AND NOVEL VIRUSES AND STRENGTHENING NATIONAL REFERENCE LABORATORY CENTER. TO ACHIEVE THIS GOAL, THE NEW FIVE YEARS COAG MAINLY FOCUS ON MAINTAINING A NATIONAL INFLUENZA SURVEILLANCE CAPACITIES TO DETECT, MONITOR, RESPOND AND MITIGATE TRANSMISSION OF NOVEL INFLUENZA VIRUSES AND ENABLING THE NATIONAL PUBLIC HEALTH LABORATORY (NPHL) TO BE A WORLD HEALTH ORGANIZATION (WHO) NATIONAL INFLUENZA CENTER (NIC).OBJECTIVES OF THIS PROPOSAL ARE: 1) TO MAINTAIN THE CAPACITY OF EPIDEMIOLOGISTS IN ROUTINE INFLUENZA SURVEILLANCE, ANALYSIS, AND OUTBREAK PREPAREDNESS & RESPONSE; 2) TO MAINTAIN AN INFORMATION MANAGEMENT SYSTEM THAT PRODUCES USEFUL DATA FOR SURVEILLANCE OBJECTIVE AN INFORMATION MANAGEMENT SYSTEM FOR INFLUENZA SURVEILLANCE DATA; 3) TO MAINTAIN SENTINEL SURVEILLANCE FOR SARI AND ILI BY EVALUATING THE LEVEL OF QUALITY & UTILITY FOR SURVEILLANCE OBJECTIVES AND ANALYSIS; 4) TO MAINTAIN INFLUENZA TESTING CAPACITY AT THE NATIONAL INFLUENZA LABORATORY THROUGH EXTERNAL QUALITY REVIEW, MANAGEMENT AND TRAINING; 5) TO PARTICIPATION AND SHARE INFLUENZA VIRUSES WITH WHO GLOBAL INFLUENZA SURVEILLANCE AND RESPONSE SYSTEM (GISRS) VIA THE WHO COLLABORATING CENTERS; 6) TO MAINTAIN SURVEILLANCE FOR OUTBREAKS OF SEVERE RESPIRATORY AND FEBRILE ILLNESSES; AND 7) TO PARTICIPATE WITH CDC?S INFLUENZA DIVISION IN RELEVANT MEETINGS, ASSESSMENTS, DISCUSSIONS AND OTHER OPPORTUNITIES AS THEY MAY ARISETO RESPOND TO THESE OBJECTIVES, NPHL AND CAMBODIA CDC HAS TO CONDUCT SEVERAL PRIORITIZED ACTIVITIES INCLUDING ORGANIZING A CONSULTATIVE MEETING WITH ALL RELEVANT STAKEHOLDERS TO REVIEW INFLUENZA AND FEBRILE ILLNESS SURVEILLANCE SOP, CONDUCTING REFRESHER TRAINING ON SPECIMEN COLLECTION, PACKAGING, AND TRANSPORT, CONDUCTING WORKSHOP ON PROBLEMS IDENTIFICATION AND SOLVING, SUPERVISING AND PR