Cooperative Agreement NU3HCK000012

This Project Grant award of $463,157 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports a research project to study the interplay between self-organization and the evolution of antimicrobial resistance (AMR) in bacterial populations. The project aims to: 1) advance a synthetic mutagenesis system to engineer Vibrio cholerae strains that enable tracking evolutionary processes in space and time, 2) use advanced...

This $999,618 project grant from the Department of Agriculture's National Institute of Food and Agriculture (NIFA) Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310) will fund the development of an antimicrobial resistance mitigation system incorporating engineered biochar adsorbents tailored to remove specific contaminants from reclaimed water. The University of California, Riverside will design a large-scale system to efficiently remove antibiotics and antibiotic...

This Cooperative Agreement award of $4,979,989.00, provided by the U.S. Department of State's Nonproliferation and Disarmament Fund (CFDA 19.224), was intended to strengthen Chile's laboratory network to meet steady-state operational demands and international requirements while maintaining capacity and agility to surge laboratory operations during a biological event. The award has been terminated in alignment with an Executive Order or ALDAC. The awardee, the General Secretariat of the...

This federal Project Grant award totaling $810,312.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research to investigate environmental reservoirs and transmission dynamics of multi-drug resistant Enterobacterales (MDR ENT) in the Chicago area. The key objectives are to: 1) Profile MDR ENT and mobile antibiotic resistance genes in Greater Chicago waterways to identify environmental...

This Project Grant award from the U.S. Environmental Protection Agency's Office of Research and Development Consolidated Research/Training/Fellowships program (CFDA 66.511) provides $2,937,765 to quantify the fate of antibiotic-resistant bacteria, genes, and antibiotics in wastewater treatment utilities across the U.S. Over 2 years, the project will sample 40 wastewater treatment facilities across 5 regions, using both culture and molecular methods to quantify antibiotic-resistant bacteria and...

This Project Grant award from the National Center for Advancing Translational Sciences (CFDA 93.350) provides $317,029 in funding to Chemia Biosciences, Inc., a small disadvantaged business, to develop advanced computational methods and software tools for discovering novel antimicrobial natural products. The project aims to leverage high-throughput mass spectrometry and genome mining techniques to identify new polysaccharides and aminoglycosides, a class of antibiotics, to address the growing...

This $2,972,025 federal Project Grant awarded by the U.S. Environmental Protection Agency's Office of Research and Development Consolidated Research/Training/Fellowships program (CFDA 66.511) aims to establish a risk assessment framework for estimating human health risks from antibiotic resistant bacteria (ARB) and antibiotic resistant genes (ARGs) in surface waters influenced by municipal wastewater and biosolids. The key activities under this grant include: Collecting field data on ARB and ARG...

This $991,832 Cooperative Agreement awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development of a novel rapid antibiotic susceptibility testing (AST) platform by Astek Diagnostics Inc., a minority-owned small business in Halethorpe, Maryland. The project aims to adapt the company's previously developed urine cartridge technology for use with cerebrospinal fluid and wound effluent specimens, characterize...

This Project Grant award of $282,000 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research to investigate the non-canonical, pyroptosis-independent role of host caspase-1 in regulating bacterial antimicrobial resistance (AMR) in intracellular pathogens like Salmonella. The research aims to elucidate the mechanism by which caspase-1 inhibits the PhoPQ two-component signaling system in...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 aims to develop a platform for detecting genetic antibiotic resistance motifs that can predict current and future susceptibility to therapeutics. The project will establish the feasibility of leveraging mutational signatures in bacterial DNA to identify antibiotic resistance status, including the potential for rapid development of multi-drug resistance. This approach...