Replicating and advancing quantitative pupillometry mtbi prognostic tool validity

The Uniformed Services University of the Health Sciences (USUHS) awarded a cooperative agreement to The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. on March 1, 2026, totaling $356,045 to replicate and advance quantitative pupillometry as a mild traumatic brain injury (mTBI) prognostic tool under the Uniformed Services University Medical Research Projects program (CFDA 12.750).

The foundation will deliver diagnostic and prognostic validation of pupil light reflex (PLR) measures for mTBI assessment and will validate short-term and long-term prognostic utility by predicting at-risk personnel health and performance outcomes. Work is performed in the United States through February 28, 2029.

Neuroptics, Inc., based in Irvine, California, serves as a sub-recipient performing statistical analysis and algorithm validation work. The sub-award, executed May 6, 2026, encompasses three specific aims: replicating diagnostic and prognostic validation work at a kinetic response laboratory (KRL4); validating short-term prognostic utility by predicting personnel health and performance using PLR measures at return-to-duty assessment; and determining long-term prognostic utility by predicting personnel health and performance using PLR measures at six months post-injury.