Following initial success in phase i with traditional PFAS compounds using solvent-based extraction, this phase II study proposes novel solvent-free extraction methods-thermal desorption (TD) and/or…

The National Institute of Standards and Technology (NIST) awarded Myexposome Inc. a Cooperative Agreement totaling $395,814.74 under the Science, Technology, Business and/or Education Outreach program (CFDA 11.620) to develop and advance novel solvent-free extraction methods for measuring per- and polyfluoroalkyl substances (PFAS) exposure. The two-year project, initiated October 1, 2025, and scheduled for completion by September 30, 2027, builds upon Phase I research to create scalable, cost-effective personal exposure monitoring tools using thermal desorption (TD) and/or purge-and-trap (P&T) techniques coupled with gas chromatography-mass spectrometry (GC-MS). These innovative solventless extraction approaches are designed to significantly reduce extraction time, costs, and contamination risks compared to conventional methods.

The project will deliver comprehensive PFAS exposure assessment capabilities targeting households, military organizations, and first responders within the United States. By leveraging Myexposome Inc.'s specialized silicone wristband technology and analytical expertise, the award supports the development of a practical tool for both research and consumer markets to provide timely and accurate individual PFAS exposure measurements. No subawards are planned under this cooperative agreement, with all work performed at the awardee's Philadelphia facility.

Activities

Activities proposed for this phase II project include research of novel solvent-free extraction methods thermal desorption (TD) and/or purge-and-trap (p & t)coupled with gas chromatography-mass spectrometry (GC-MS). These approaches aim to significantly reduce extraction time, costs, and contamination risks inherent in conventional methods.

Expected outcomes

The novel solvent-free extraction methods to be developed in phase II are expected to significantly reduce extraction time, costs, and contamination risks inherent in conventional methods.

Intended beneficiaries

Households, military organizations, and first responders within the united states.

Subrecipient activities

The award recipient does not intend to make any subawards.