This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) provides $330,076 to Trestle Optics LLC, a small disadvantaged business located in Irvine, California, to develop an advanced photothermal microscopy platform for non-destructive profiling of cellular metabolites. The goal is to integrate photothermal microscopy with spatial light interference imaging to create a system capable of monitoring the...
This $387,579 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to advance computational modeling of disease metabolism by integrating artificial intelligence (AI) and systems biology. The project at Oregon Health & Science University (OHSU) seeks to: Characterize metabolic landscapes in disease systems using a systematic, data-driven approach; Leverage multi-omics data and existing...
This Project Grant award of $532,947 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development and validation of a unified, cloud-based data processing workflow and database called LC-BINBASE for high-resolution LC-MS/MS metabolomics and lipidomics data. The project, led by researchers from UC Davis, University of Michigan, and Pacific Northwest National Laboratory, aims to harmonize and...
This $385,700 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support the development of advanced computational frameworks to enhance understanding of pharmacogenomic mechanisms in complex diseases. Over the 5-year award period from September 2024 to August 2029, the key products and services to be delivered include: 1) deep learning models that integrate multi-omic data to...
This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $270,428 to TEO Therapeutics Incorporated to develop and test a proof-of-concept biomimetic platform for more efficient pharmaceutical drug development in oncology. The project aims to refine and optimize a hardware product line for a shell-free quail xenograft assay, and develop a prototype bioware kit with temperature-appropriate packaging and a simplified...
This federal Project Grant award from the National Institute on Minority Health and Health Disparities (NIMHD), under the Minority Health and Health Disparities Research (CFDA 93.307) program, provides $588,900 to Precision Quantomics, Inc. to develop two key products: The Underrepresented Population Drug Target Protein (UPDTP) Database, which will capture the abundance of drug target proteins in human liver across diverse populations. This addresses a critical gap in current...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development of efficient and accurate methods for identifying novel natural product small molecules from complex mass spectral datasets. The $275,484 award, which began on Sep 1, 2023 and runs through Aug 31, 2024, will enable the grantee, Chemia Biosciences, Inc., to integrate genome mining with computational metabolomics to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA program 93.859 Biomedical Research and Research Training, provides $202,274 to Acpharis in Holliston, MA to develop an algorithm and software for predicting the structure and degrading efficiency of proteolysis targeting chimeras (PROTACs). The key products to be delivered include: 1) An easy-to-use computer program that can accurately model POI-PROTAC-E3 ligase ternary complexes, 2) Methods to...
This $258,586 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of a novel surface sampling device and ionization technology for mass spectrometry. The goal is to demonstrate the feasibility of a "remote surface reader" that can safely and accurately detect a range of biological compounds, such as those associated with infectious diseases, hazardous materials,...
The National Institute of General Medical Sciences (NIGMS) awarded a $314,363 Project Grant under CFDA 93.859 (Biomedical Research and Research Training) to Delineate Inc., a for-profit, woman-owned small business located in Medford, MA. The grant, which runs from April 1, 2025 to March 31, 2026, aims to develop an innovative platform that uses large language models (LLMs) to accelerate the building and repurposing of quantitative systems pharmacology (QSP) models from scientific literature. The...