Cooperative Agreement 5880646004F0

The University of Missouri System, under a $650,000 project grant from the USDA National Institute of Food and Agriculture (NIFA) Agriculture and Food Research Initiative (AFRI) program, is developing safe and effective live attenuated swine influenza vaccines using Newcastle disease virus (NDV) as the vector. The project aims to address the challenges with current swine influenza vaccines, which often fail to provide cross-protection against diverse virus strains. The key products and...

This $809,614 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to develop broadly neutralizing human monoclonal antibodies (BnAbs) against Henipaviruses, which are highly pathogenic viruses causing severe respiratory and neurological diseases in humans and animals. The key objectives are to: 1) comprehensively characterize existing BnAbs generated from transgenic mice, 2)...

Biostone Animal Health LLC was awarded an $800,000 Project Grant from the US Department of Agriculture National Institute of Food and Agriculture under the Agriculture and Food Research Initiative competitive grants program. The three-year award will support the development of diagnostic tools and monoclonal antibodies for African swine fever virus. Specifically, the company will further develop, optimize, and validate two enzyme-linked immunosorbent assays (ELISAs) to differentiate infected...

The University of Illinois received a $800,000 three-year Project Grant award from the United States Department of Agriculture's National Institute of Food and Agriculture under the Agriculture and Food Research Initiative competitive grants program. The University will evaluate the protective efficacy of Orf virus and Pseudorabies virus vectors expressing African Swine Fever Virus protective antigens of the epidemic Georgia-07 strain through vaccination challenge experiments in pigs. It will...

This $238,098 Cooperative Agreement award from the U.S. Department of Agriculture's Animal and Plant Health Inspection Service (APHIS) under the Plant and Animal Disease, Pest Control, and Animal Care program (CFDA 10.025) is focused on developing improved emergency response capabilities for potential animal disease outbreaks, like African swine fever, in the state of Oklahoma. The key objectives are to: 1) survey pig ownership and assess carcass disposal methods among Oklahoma residents,...

The University of Nebraska was awarded a $627,000 Project Grant from the US Department of Agriculture's National Institute of Food and Agriculture under the Agriculture and Food Research Initiative competitive grants program. The three-year award running from May 1, 2023 to April 30, 2026 will support research on porcine reproductive and respiratory syndrome virus (PRRSV) infection pathways and identification of additional cellular factors required for PRRSV replication. Specifically, the...

The U.S. Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA) awarded a $650,000 Project Grant under the Agriculture and Food Research Initiative (AFRI) program to Kansas State University (KSU) on September 1, 2024. The grant supports two main objectives: (1) developing an effective, DIVA-compatible (Differentiating Infected from Vaccinated Animals) classical swine fever (CSF) vaccine that can rapidly and strongly protect pigs against CSF disease, and (2)...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $476,453 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to Trustees of Boston University to develop intein-based tools to study Ebola virus (EBOV) replication. The key objectives are to: Systematically evaluate intein insertion sites and develop improved intein-based reporters for EBOV, directly comparing them to traditional reporter viruses. Establish an intein-based "off-switch" to...

Oklahoma State University will receive $650,000 from the United States Department of Agriculture National Institute of Food and Agriculture under the Agriculture and Food Research Initiative Competitive Grants Program (AFRI CGP) to develop an oral live attenuated vaccine for Porcine Epidemic Diarrhea Virus (PEDV). PEDV has caused significant losses to the U.S. pork industry since 2013, with current commercially available vaccines providing limited protection. The university will identify...

This $820,940 Project Grant award from the National Institute of Allergy and Infectious Diseases (under CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at Georgetown University to develop a modified hepatitis B virus (HBV) or modified woodchuck host that can productively infect woodchucks. This would establish a new animal model for chronic HBV infection to enable the preclinical evaluation of new antiviral drugs and a better understanding of HBV persistence. Key...