Cooperative Agreement 2534171
- The National Science Foundation (NSF) awarded a $2,526,095 Cooperative Agreement to Arzeda Corp, a biotechnology company based in Seattle, Washington, under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084). The project aims to transform the electrochemical conversion of carbon dioxide (CO2) to methanol by developing a highly efficient, cell-free enzymatic cascade system. The research will integrate AI-driven enzyme design, synthetic chemistry, and advanced...
- This National Science Foundation (NSF) Cooperative Agreement award, funded under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program, will support the development and commercialization of a cost-effective peptide production platform by the small business Oakgrove Bio LLC. The $1,000,000 project aims to scale-up a recombinant technology that will dramatically decrease the cost of manufacturing peptides, which have significant potential applications ranging from antimicrobials...
- This Cooperative Agreement award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program provides $1,248,994 to Opera Bioscience, Inc., a woman-owned small business in Evanston, Illinois, to further develop an innovative bacterial protein secretion platform technology. The project aims to create a commercially viable, cost-effective protein expression platform capable of producing multiple classes of proteins at an industrial scale, while meeting...
- This Cooperative Agreement award, funded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, supports the development of a novel platform for protein engineering and production using a hybrid in-vivo, in-vitro, and in-silico approach. The $2,808,001 project, executed by Caravel Bio, Inc., aims to overcome the high costs and scalability challenges of cell-free biosynthesis through the integration of four advanced technologies:...
- This $1,000,000 Cooperative Agreement award from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program aims to accelerate R&D in the pharmaceutical industry through the development of streamlined machine learning algorithms for small data applications in advanced manufacturing. The project, awarded to Sunthetics Inc., seeks to save time and resources by up to 95% in lead optimization and route scouting during pre-clinical drug development by...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $1,000,000 Project Grant under the Biological Sciences program (CFDA 47.074) to the University of Wisconsin-Madison. The 3-year grant, effective September 1, 2023, supports a collaborative research project between the University of Wisconsin-Madison and members of the Department of Energy's Agile Biofoundry to investigate bacterial transporters and engineer them for superior properties in...
- This $2,996,108 Cooperative Agreement awarded by the National Science Foundation (NSF) under its Technology, Innovation, and Partnerships (CFDA 47.084) program aims to develop more efficient cell-free biomanufacturing processes. The project is creating membraneless compartmentalization techniques using custom-designed enzymes and innovative materials. This approach enables the simultaneous execution of multiple redox reactions required to produce valuable chiral chemicals, overcoming the...
- The National Science Foundation (NSF) awarded a $2,686,207 Cooperative Agreement titled "IDEAS LAB: USPRD: DE NOVO DESIGN AND EVOLUTION OF ENZYMES FOR BIOMASS UPCYCLING TO SURFACTANTS AND FUELS" under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The project aims to transform plant materials into high-value products like fuels, oils, and surfactants using artificial intelligence and machine learning to enhance the activity of key enzymes for biomass...
- This Cooperative Agreement award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program provides $2,233,515 to support a project by Arzeda Corp to transform the production of acrylates through the use of AI-designed enzymes and non-natural cofactors. The project aims to develop a scalable, cost-effective, and cell-free biocatalytic process for producing methylene butyrolactone (MBL), a bio-based acrylate monomer. This will involve engineering...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Om Therapeutics Inc. will support the development of a system to enable the rapid, scalable, and cost-effective discovery of new medicines using machine learning. The project aims to encapsulate proteins and small molecules in millions of miniaturized compartments to screen for interactions that could identify novel drug candidates. The key innovations include...
The National Science Foundation (NSF) awarded a $2,375,361 Cooperative Agreement to Koliber Biosciences Inc. under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The project aims to develop computational tools that leverage artificial intelligence and machine learning to design improved protein "transporter" molecules. These transporter proteins control the movement of valuable chemicals in and out of cells, which is a critical limitation in microbial bioproduction systems. The tools will enable researchers to more efficiently identify and optimize transporters for specific target molecules, supporting faster and more cost-effective biomanufacturing of products like fragrances, polymers, and food supplements. This innovation is expected to strengthen domestic manufacturing, reduce supply chain risks, and drive economic growth by enabling the use of renewable resources like plant waste to produce commodity chemicals. The project will run from May 2025 to December 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/18/25 | ||
| Not listed | $2.4m | 7/25/25 |