This Cooperative Agreement award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $2,572,498 in funding to Purdue University to develop new bioplastics with enhanced thermal stability and recyclability. The project aims to engineer polyketide synthases (PKSs) within bacteria to produce monomers for polyhydroxyalkanoates (PHAs) that can withstand high temperatures and be easily recycled or biodegraded. It will leverage advanced computational protein design tools to create hybrid PKSs capable of synthesizing gem-dimethylated PHAs (GDPHAs) with improved properties. The effort will also establish workflows for PKS pathway retrosynthesis, computational protein design tools, and methodologies for high-GC DNA synthesis to broadly enable enzyme engineering and domestic biomanufacturing. Additionally, the project will include outreach to train the next generation of biotechnologists and provide open-source tools to foster future innovations. The award period runs from May 1, 2025 to April 30, 2028.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $2.6m | 4/24/25 |