BII: polyploidy: integration across scales and biological systems

Active Cooperative Agreement Awarded Last action

Award ID
2320251
Recipient
Awarding agency
Obligated
$6,345,720

Award facts

Assistance listing
47.074 Biological Sciences
Completion date 41% complete
Place of performance
Gainesville, FL 32611, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Polyploidy, or the presence of three or more sets of chromosomes within a cell, is a widespread feature of genomes, cells, and organisms. Polyploidy was discovered over 100 years ago, but our understanding remains limited, even though nearly all agricultural crops are polyploid, many human organs (for example, liver, heart, and placenta) are polyploid, and at least one-third of all cancers are polyploid. A common theme is that polyploidy is often associated with stress, but few other generalities have emerged, in part because researchers across diverse fields?from cell biology to genomics, agriculture, cancer, and ecology?rarely interact. The polyploidy integration and innovation institute will bring a unique, synthetic approach to the study of polyploidy, with integrated analyses that will uncover both the commonalities and distinct roles of polyploidy in cells to ecosystems and in plants, animals, and fungi. A coordinated research plan across carefully selected biological systems will serve as a framework for predictive models that will extend the experimental work more broadly, with important consequences for agriculture, medicine, conservation of biodiversity, and development of the bioeconomy. Moreover, the institute will transform scientific understanding of polyploidy and its relevance for society through integration of research, cross-disciplinary education and training, public outreach, and programs to diversify the scientific workforce. Polyploidy occurs at the levels of cells, tissues, organs, and entire organisms and ultimately results in transformative downstream effects that occur across biological scales and diverse organisms. Nucleotypic effects of increased ploidy (that is, effects due to increased DNA content alone) may impact cell size, gene expression, gene interaction networks, protein production, and more, producing a mosaic of potential positive and negative outcomes. Explanations for the advantages and constraints of polyploid cells and organisms remain elusive, in part because broad-scale comparisons have not been made. The polyploidy integration and innovation institute will conduct coordinated research in yeast, arabidopsis, duckweed, chlamydomonas, and fruit flies to test the central hypothesis that there are underlying rules to polyploidy that act across levels of biological organization and organismal systems. Parallel experiments across these model systems will test specific hypotheses about the common impact of nucleotypic effects across systems and whether the rules that determine polyploid success at the cellular and organismal levels ultimately scale to populations and landscapes. This novel predictive and quantitative framework for the cellular, organismal, evolutionary, and ecosystem-level consequences of polyploidy has not previously been possible because research on polyploidy has been siloed. Collaborations with the broader scientific community will extend this research paradigm to many other lineages of life. The inherently interdisciplinary nature of polyploidy is reflected in a training program that is integrated with the institute?S conceptual research framework and emphasizes experimental and analytical methods as well as skills in team science, data science, and science communication. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria.- subawards are planned for this award.

Transactions

Action Obligated Date
Amendment $2,427,675
Amendment $2,383,462
Original award $1,534,583

Subawards

Subrecipient Amount Awarded
Cornell University My role and my laboratory’s role in this project are primarily to provide expertise in polyploidy at the cell to tissue scale in Arabidopsis. First, we will… $580,571
Regents Of The University Of Minnesota My role in this project is to oversee all experiments proposed in Saccharomyces cerevisiae. My laboratory will perform all strain construction and molecular… $615,388
University Of Kentucky My role in this project is primarily to provide mathematical modeling expertise and statistical inference. I will provide models, simulations, and data… $264,525
The University Of Mississippi Dr. Chen’s role in this project is to conduct protein sample preparation from different types of samples, process the samples through liquid chromatography mass… $235,480
University Of Pittsburgh - Of The Commonwealth System Of Higher Education Our role in this project is to conduct population dynamic, transcriptomic and proteomic studies of polyploidy in the duckweed Spirodel polyrhiza. We will… $786,553
Duke University My role in this project is to oversee all experiments proposed in Drosophila melanogaster. My laboratory will perform all of the fitness tests in this… $600,045
Cornell University My role and my laboratory’s role in this project are primarily to provide expertise in polyploidy at the cell to tissue scale in Arabidopsis. First, we will… $278,877
The University Of Mississippi Dr. Chen’s role in this project is to conduct protein sample preparation from different types of samples, process the samples through liquid chromatography mass… $113,183
Duke University My role in this project is to oversee all experiments proposed in Drosophila melanogaster. My laboratory will perform all of the fitness tests in this… $288,953
University Of Kentucky My role in this project is primarily to provide mathematical modeling expertise and statistical inference. I will provide models, simulations, and data… $239,823
Regents Of The University Of Minnesota My role in this project is to oversee all experiments proposed in Saccharomyces cerevisiae. My laboratory will perform all strain construction and molecular… $316,050
University Of Pittsburgh - Of The Commonwealth System Of Higher Education Our role in this project is to conduct population dynamic, transcriptomic and proteomic studies of polyploidy in the duckweed Spirodel polyrhiza. We will… $382,549
University Of Kentucky My role in this project is primarily to provide mathematical modeling expertise and statistical inference. I will provide models, simulations, and data… $249,346
The University Of Mississippi Dr. Chen’s role in this project is to conduct protein sample preparation from different types of samples, process the samples through liquid… $122,633
Duke University My role in this project is to oversee all experiments proposed in Drosophila melanogaster. My laboratory will perform all of the fitness tests in this… $297,393
Cornell University My role and my laboratory’s role in this project are primarily to provide expertise in polyploidy at the cell to tissue scale in Arabidopsis. First, we… $153,110
University Of Pittsburgh - Of The Commonwealth System Of Higher Education Our role in this project is to conduct population dynamic, transcriptomic and proteomic studies of polyploidy in the duckweed Spirodel polyrhiza. We will… $224,405
Regents Of The University Of Minnesota My role in this project is to oversee all experiments proposed in Saccharomyces cerevisiae. My laboratory will perform all strain construction and molecular… $318,835
Show all 18

Quick answers

Who received award 2320251?

2320251 was awarded to University Of Florida by Division of Biological Infrastructure (National Science Foundation) on June 1, 2024.

How much is award 2320251 worth?

$6,345,720 has been obligated on 2320251.

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