RII track-2 FEC: advancing manufacturing and biotechnology through an on-demand sensor platform: investments in the development of engineering principles and the future workforce

Ended Cooperative Agreement Awarded Last action

Award ID
2119237
Recipient
Awarding agency
Obligated
$5,997,238

Award facts

Assistance listing
47.083 Integrative Activities
Completion date
Place of performance
Lee, NH 03824, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The proposed research represents a comprehensive advancement in biosensor design, biotechnology, and engineering and prepares AL, me, NH, and WY to take full advantage of the anticipated growth of biotechnology and advanced manufacturing industries. Today, biomanufacturing industries are limited by a lack of effective tools for monitoring key proteins which provide information on product quality in real time. Current protein sensors are limited to spectroscopic measurements (which are non-specific and require expensive equipment) or off-line, laboratory-based approaches. To address the need for on-demand biosensors to continuously monitor proteins in biomanufacturing processes, we have assembled a geographically diverse team from the university of new hampshire, auburn university, the university of new england, the university of wyoming, and the university of maine. This research will be coupled with a multi-tiered workforce development plan integrated throughout the project that includes training for a new biotechnology workforce in AL, me, NH, and WY. The workforce development includes individual components for early-career faculty, postdoctoral scholars, graduate and undergraduate students, k-12 students, and the broader communities in the jurisdictions, all tied together through an annual academic-industry symposium. The proposed research represents a comprehensive advancement in biosensor design, biotechnology, and engineering and prepares AL, me, NH, and WY to take full advantage of the anticipated growth of biotechnology and advanced manufacturing industries. Today, biomanufacturing industries are limited by a lack of effective tools for monitoring key proteins which provide information on product quality in real time. The project will develop engineering principles to guide on-demand biosensor design towards industry 4.0 applications. Four distinct yet collaborative research projects will produce a full assortment of sensor components to achieve the continuous, in-line process monitoring that is essential for economically viable quality-by-design biomanufacturing. Project 1 focuses on the development and validation of computational methods to design protein recognition elements (RES) with targeted hotspot interactions. Project 2 will produce engineering principles for creating analyte-responsive polymers that amplify the signal of analyte binding to RES at process conditions. Project 3 will develop innovative scanning electrochemical cell microscopy techniques to reproducibly nanopattern surfaces to control sensor form factors and array construction. Finally, project 4 will measure the electrochemical transduction of surface events of analyte-responsive polymers and test designed sensors for measuring IL-6 and insulin in-line and continuously. Combined, the four projects will be integrated into a single sensor device capable of measuring changes in protein levels, specifically IL-6 and insulin, continuously and in real time for industrial applications. This research represents a close collaboration with researchers from a geographically diverse team from the university of new hampshire, auburn university, the university of new england, the university of wyoming, and the university of maine, and will be coupled with a multi-tiered workforce development plan integrated throughout the project that includes training for a new biotechnology workforce in AL, me, NH, and WY. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria.

Transactions

Action Obligated Date
Amendment $1,499,489
Amendment $1,498,746
Amendment $1,499,761
Original award $1,499,242

Subawards

Subrecipient Amount Awarded
University Of Wyoming Research $53,074
University Of New England -$97,829
University Of Maine System -$30,335
Auburn University $96,614
Auburn University $121,589
University Of New England $163,540
University Of Maine System $83,876
University Of Wyoming $206,406
Auburn University $28,477
University Of Maine System The project will embed within its design the ability to monitor and assess the economic dynamics present within each of the EPSCoR jurisdictions in a novel… $84,156
Auburn University The Pantazes Lab as led by Dr. Pantazes will redesign known binding proteins to alter their affinity and charge, develop novel methods of designing binding… $146,339
University Of Wyoming An adaptable, in-line sensing platform will be developed for application in biomanufacturing settings. The developed platform will utilize… $206,406
University Of New England This grant describes work creating a novel platform for on-demand biosensors for advanced biomanufacturing (e.g., large scale manufacturing of pancreatic… $193,660
Show all 13

Quick answers

Who received award 2119237?

2119237 was awarded to University System Of New Hampshire by Office of Integrative Activities (National Science Foundation) on March 1, 2022.

How much is award 2119237 worth?

$5,997,238 has been obligated on 2119237.

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