Cooperative Agreement 2111884

This Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program totaling $511,798 was awarded to Kilele Health Inc. on June 15, 2022 to develop continuous diagnostic monitoring platforms beyond glucose sensing. Unlike existing enzymatic glucose sensors, the company will utilize electrochemical aptamer sensors that can rapidly measure other molecules in the body with high specificity and sensitivity. The aim is to address limitations that have...

This $255,706 National Science Foundation SBIR Phase I Project Grant to Metfora LLC supports the development of a novel multiplexed metabolite diagnostic blood test for early detection of chronic diseases. The NSF Technology, Innovation, and Partnerships program aims to advance science and engineering solutions to national challenges through innovation and partnerships. Specifically, Metfora will use mass spectrometry and artificial intelligence to analyze specific panels of circulating...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the federal Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $2,328,157 to develop a miniaturized, disposable CMOS-based point-of-care (POC) system for detecting biomarkers in complex samples. The key innovations include aptamer switches that generate binding-specific electrochemical signals without sample preparation,...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $295,895 to Ricovr Healthcare Inc. to develop a rapid, low-cost, point-of-care (POC) diagnostic platform for quantitative measurement of placental growth factor (PlGF) to predict and detect pre-eclampsia. The goal is to create an objective, affordable POC tool to improve the clinical diagnosis and monitoring of pre-eclampsia, which...

This National Science Foundation (NSF) Small Business Innovation Research (SBIR) Phase I Project Grant, awarded under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program, provides $304,966 to support the development of a portable, rapid point-of-care diagnostic device capable of simultaneously detecting and quantifying multiple blood-based biomarkers. The project aims to create an integrated cartridge/analyzer system that can automate serum separation and buffer dilution to...

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $349,734 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Actiox LLC, a biomedical technology company in Thousand Oaks, California. The project aims to develop a wearable microneedle-based biosensor for continuous, real-time cardiac troponin I monitoring. The goal is to demonstrate the feasibility of this transformative biosensor technology to enable earlier detection of ischemic events and...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Cooperative Agreement award for $997,142 aims to develop a rapid phenylalanine blood level monitor for patients with phenylketonuria (PKU), a lifelong genetic disorder. The product consists of a test strip and device that can provide frequent, accessible monitoring of phenylalanine levels from a finger prick to improve disease management and patient outcomes. The project focuses on optimizing the...

RCE Technologies, Inc. was awarded a $255,892 Small Business Innovation Research Phase I Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program to develop a proof-of-concept machine learning-based diagnostic system for detecting myocardial infarction and ischemia in real-time. The system aims to provide point-of-care clinical classification for heart attack cases using a novel, portable device integrating the awardee's proprietary external...

This SBIR Phase I project, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to develop an automated system to streamline the sample preparation process for liquid biopsy cancer testing. The $305,000 award will fund the creation of a microfluidic-based instrument that automates the bisulfite conversion step, a critical but time-consuming and error-prone process in preparing circulating tumor DNA for epigenetic...

This $305,000 STTR Phase I Project Grant awarded by the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program aims to develop an ultra-sensitive biosensor capable of protein analysis at single-molecule resolution. The biosensor consists of a nanopatterned chip with a proprietary scaffold material that binds and immobilizes molecular targets, which are then detected using surface-enhanced Raman spectroscopy (SERS). This innovation seeks...