Purchase Order 75N95022P00218

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $99,000.00 firm-fixed price purchase order to Cyclope Bio SL, a for-profit manufacturer, to acquire Enantiomers of Cyclopentane Diamine and Tetrahydrofuran Diamine. These chemicals are essential starting materials for the NIDDK's Synthetic Bioactive Molecules Section's research on developing new diagnostic kits to detect nucleic acids associated with diseases. The purchase order has a completion date of...

The Department of Health and Human Services National Institutes of Health National Center for Advancing Translational Sciences awarded a $827,789 firm fixed price delivery order against its CRO Support for NCATS Drug Substance Development and Manufacture master IDIQ contract to Bachem Americas, Inc. to support the manufacture of 1 kg of CGMP L-ENK in support of the Center's drug substance development and manufacture program. Performance will take place in Torrance, California over a four-year...

This firm fixed-price purchase order, valued at $10,900, was awarded by the Department of Health and Human Services' National Institutes of Health National Center for Advancing Translational Sciences to Pointcare Systems Inc. R&D Division, doing business as Chirosolve, for the synthesis of tert-butyl (R)-3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)piperidine-1-carboxylate in a 75 gram quantity with over 95% purity. The solicitation sought synthesis and delivery of the specified intermediate...

This federal contract award is for the manufacture of 5.5-kg of cGMP mitragynine, a drug substance, by Curia Global Inc. (doing business as Amri). The award, with a ceiling value of $3,370,313.00, was issued by the National Center for Advancing Translational Sciences (NCATS), a civilian agency under the Department of Health and Human Services. This is a delivery order under the CRO Support for NCATS Drug Substance Development and Manufacture indefinite-delivery/indefinite-quantity (IDIQ)...

This federal contract award, valued at $50,000.00, was issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a civilian agency within the Department of Health and Human Services, to the prime contractor Entrechem SL. The contract is for the purchase of 100 grams each of two specific enantiomers of trans-N-Boc-1,2-tetrahydro-3,4-furandiamine. These chemical compounds are needed as starting materials for the NIDDK's research into developing thyclotides, which...

This is a $107,700.00 firm fixed-price purchase order awarded by the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health, to Curia Global Inc. (doing business as Amri) for cGMP mitragynine HCl supplemental stability and analytical activities. The work supports the preclinical development of mitragynine as part of NCATS' Helping to End Addiction Long-term (HEAL) initiative. Curia, a leading contract development and manufacturing organization,...

The Department of Health and Human Services' National Institutes of Health National Institute on Drug Abuse awarded a firm fixed-price purchase order valued at $22,500 to the University of Kansas Center for Research, Inc. This award is pursuant to a request for quote to develop a manufacturable tablet formulation of the compound NCGC72 for use in dog sarcoma clinical studies. The prime contractor will non-GMP manufacture 1,500 tablets total, with 1,000 tablets at 50mg dosage and 500 tablets at...

<p>This is a firm fixed-price purchase order awarded by the Food and Drug Administration (FDA), a civilian agency, to Chiralix B.V., a for-profit organization, for the custom synthesis of a cyclic depsipeptide titled &quot;CLOSELY ASSOCIATED&quot;. The award has a ceiling value of $19,160.00 and an ultimate completion date of July 31, 2015. The contract was awarded on March 4, 2015 and does not have a set-aside designation.</p>

The Department of Health and Human Services National Institutes of Health National Center for Advancing Translational Sciences awarded a $29,820 firm fixed price purchase order to Medchemexpress LLC to deliver forty-four bioactive compounds for replenishment and expansion of the Mechanism Interrogation PlatE 6.0 screening library. The compounds will support the Center's high-capacity robotic platform used to screen drug combinations and further its chemogenomic screening capabilities. Delivery...

This is a $3,171,368.00 cost-plus-fixed-fee delivery order awarded to Alchem Laboratories Corporation, a for-profit manufacturer of pharmaceutical products, by the National Cancer Institute (NCI), a civilian agency. The contract is for the synthesis of up to ten non-GMP (non-Good Manufacturing Practice) small molecule samples per year, as continuity for the NCI's Program 66C, through September 2026. Alchem Laboratories holds multiple federal indefinite delivery vehicle (IDV) contracts for...