Purchase Order 75N92022P00376

The Department of Health and Human Services National Institutes of Health National Institute of Allergy and Infectious Diseases awarded a $12,085,422.00 cost plus fixed fee delivery order contract to Sri International of West Menlo Park, California to perform animal model development and efficacy testing from September 19, 2022 through September 29, 2026. A subcontract valued at an undisclosed amount was also awarded to The Medical College of Wisconsin, Inc. to conduct a non-good laboratory...

This federal contract, awarded by the National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS), is for testing a compound called NCGC00846044 in the SUGEN-Hypoxia mouse model of pulmonary hypertension. The contract, with a potential value of $87,286, was awarded to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), a non-profit 999-bed medical center affiliated with Harvard Medical School. The contract requires MGH to...

This federal contract award to Scantox Neuro GMBH, a for-profit organization based in Austria, is for $249,000.00 to conduct tolerability studies of candidate Alzheimer's disease (AD) drugs and evaluate the efficacy of poly(L-lysine succinylated)-hydroxychloroquine (PLS-HCQ) in a transgenic AD mouse model. The award is part of the Drug Repurposing for Effective Alzheimer's Medicines (DREAM) and Experimental Validation of Candidate Alzheimer's Disease Treatments Identified by Multi-Omics Analyses...

This is a $249,167.58 firm fixed price purchase order awarded by the National Center for Advancing Translational Sciences (NCATS), a civilian agency under the National Institutes of Health (NIH), to Gempharmatech LLC, a foreign-owned for-profit biotech company. The contract is for the development of humanized mouse models for nicotinamide N-methyltransferase (NNMT) and sulfotransferase (SULT1A1) using CRISPR knock-in technology. The contractor will conduct biochemical testing of inhibitors and...

Chemogenics Biopharma, LLC has been awarded a $23,540 firm fixed price purchase order by the National Institutes of Health's National Center for Advancing Translational Sciences to evaluate the pharmacokinetics of aldometanib in mice. Under the non-competitive contract, Chemogenics will determine aldometanib concentrations in various tissues through synthesis of the compound following a multistep sequence and analytical methods to analyze aldometanib levels. The company will also report and...

This is a firm fixed-price purchase order awarded by the Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) to PGI Holding Corporation, a for-profit subchapter S corporation, to evaluate the efficacy of a nanoparticle formulation containing the drug aprepitant in a rodent model of neuropathic pain. The contract, valued at $216,900.00, has a period of performance from September 20, 2021 to March 31,...

The Department of Health and Human Services National Institutes of Health National Center for Advancing Translational Sciences awarded a $581,604 firm fixed price purchase order to Avista Pharma Solutions, Inc., doing business as Cambrex, to acquire approximately 2-3 kilograms of cGMP-grade GS-441524 for potential treatment of COVID-19. The award is pursuant to a combined synopsis/solicitation seeking this same cGMP material from Avista, as they are currently producing non-cGMP GS-441524 under...

This is a firm fixed-price purchase order awarded by the National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) to Bioqual, Inc., a small business contractor. The contract is for a 4-week in-vivo efficacy study of a niclosamide prodrug in a golden Syrian hamster model of SARS-CoV-2 (COVID-19), with a potential value of $105,275.00. Bioqual is a prime contractor that provides animal research services, including housing, care and maintenance of research...

The Department of Health and Human Services' National Institutes of Health's National Center for Advancing Translational Sciences awarded a $13,474 purchase order to Horizon Discovery Biosciences Limited of Great Britain. Under the firm fixed price contract, Horizon Discovery will provide ON-TARGETPLUS MOUSE AAK1 small interfering RNA SMARTPOOL consisting of 50 nanomoles of the described product. Place of performance will be Great Britain, with work occurring between September 5 and November...

The Department of Health and Human Services National Institutes of Health National Heart Lung and Blood Institute awarded a $996,710 firm fixed price purchase order to Lumicks USA Inc. to generate HBB, HBBS, and HBBE knock-in mice. The solicitation sought a contractor capable of generating transgenic and knock-in mouse models using CRISPR/Cas9 or other genome editing technologies for biomedical research purposes. No set-aside designation or incumbent contractor was specified. Lumicks will...