Real-time, real-world, real-impact (R3)

Active Other Transaction Agreement Awarded Last action

Contract number
140D042490007
Awardee
Awarding agency
Obligated
$33,342,110

Award facts

Contract value 100% obligated
$33,342,110.00 Current and potential, with all options
Completion date 51% complete
  • Current, with exercised options
  • Potential, with all options
Funding agency
National Institutes of Health Department of Health and Human Services
NAICS code
Not on record
Competition
Competed Program Solicitation
Pricing
Other
Place of performance
Philadelphia, PA 19104, USA

Award details come from SAM.gov/FPDS.

Transactions

Action Obligated Date
Other Administrative Action P00003 $23,425,000
Supplemental Agreement for work within scope P00002 · Real-time analysis and discovery in integrated and networked technologies (radiant) / pediatric care expansion (PCX) $0
Other Administrative Action P00001 · Real-time, real-world, real-impact (R3): a national data fabric framework for pediatric cancer and other rare diseases $0
Original award $9,917,110

About this award

The National Institutes of Health awarded an Other Transaction Agreement to The Children's Hospital of Philadelphia (operating through The Children's Hospital of Philadelphia Research Institute) on September 17, 2024, with a ceiling value of $33.342 million and an ultimate completion date of October 17, 2028. This OTA sits outside the FAR framework.

The effort supports the Real-Time, Real-World, Real-Impact (R3) program, which encompasses development of the RADIANT (Real-Time Analysis and Discovery in Integrated and Networked Technologies) clinical data platform and Pediatric Care Expansion initiatives. The R3 portal and toolset integrate real-time clinical data ingestion, automated clinical data validation, genomic data infrastructure, and natural language query capabilities to enable rapid availability of pediatric research data across translational care and research-informed clinical workflows.

Work is performed in Philadelphia, Pennsylvania. CHOP serves as the primary coordinating center alongside implementation sites at the University of California San Francisco and the Pediatric NeuroOncology Consortium. Major subcontractors include Children's Hospital Los Angeles (implementing Radiant connectors and clinical data validation for the PNOC030 ATRT Registry pilot, awarded April 23, 2026), The Regents of the University of California San Francisco (leading clinical trial workflow coordination and EMR data abstraction integration, with dual awards May 19 and April 9, 2026), Centre Hospitalier Universitaire Sainte-Justine in Montreal (leading development of the R3 web data portal software solution, May 28, 2025), and Seattle Children's Hospital (coordinating CBTN clinical data workflows and validation, April 14, 2025).

Subawards

Subcontractor Amount Awarded
Children's Hospital LOS Angeles REAL-TIME, REAL-WORLD, REAL-IMPACT (R3) PNOC030 (ATRT Registry) has been designated as a RADIANT pilot use case to support the development, testing, and… $131,938
The Regents Of The University Of California. San Francisco REAL-TIME, REAL-WORLD, REAL-IMPACT (R3) Statement of Work The University of California San Francisco (UCSF) will be an implementation site for the Real-time,… $678,873
Centre Hospitalier Universitaire Sainte-Justine REAL-TIME, REAL-WORLD, REAL-IMPACT (R3) The Research Center of the Sainte-Justine University Hospita, in close collaboraton wih its partners at CHOP and UCSF,… $1,193,800
The Regents Of The University Of California. San Francisco REAL-TIME, REAL-WORLD, REAL-IMPACT (R3) Statement of Work The UCSF genomic portal is a local instance of the Kids First infrastructure hosted fully in a UCSF… $100,000
Seattle Children's Hospital REAL-TIME, REAL-WORLD, REAL-IMPACT (R3) Seattle Children’s Hospital, under the direction of Dr. Leary, will coordinate the CBTN clinical data workflows and… $600,000

Quick answers

Who was awarded contract 140D042490007?

140D042490007 was awarded to The Children's Hospital Of Philadelphia by Interior Business Center (Office of Policy Management and Budget) on September 17, 2024.

How much is contract 140D042490007 worth?

The government has obligated $33,342,110 on 140D042490007.

Which agency awarded contract 140D042490007?

Interior Business Center (Office of Policy Management and Budget) awarded 140D042490007, with funding from National Institutes of Health (Department of Health and Human Services).

Was contract 140D042490007 competed?

The extent of competition for 140D042490007 was competed.

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