Specifically, we postulate that microgravity may decrease MSC number and disturb the secretion of trophic factors that impede bone homeostasis by reducing new bone formation and/or increasing bone…

Active Grant For Research Awarded Last action

Contract number
80NSSC21K0299
Awardee
Awarding agency
Obligated
$1,090,755

Award facts

Contract value 100% obligated
$1,090,755.00 Current and potential, with all options
Completion date 95% complete
Current and potential, with all options
Contracting staff
NAICS code
Not on record
Set-aside
No set-aside
Competition
Full and Open Competition Basic Research
Pricing
Other
Place of performance
Jacksonville, FL 32224, USA

Award details come from SAM.gov/FPDS.

Transactions

Action Obligated Date
Other Administrative Action P00011 $0
Funding Only Action P00010 $25,000
Funding Only Action P00009 $154,486
Other Administrative Action P00008 $0
Additional Work (new agreement, FAR part 6 applies) P00007 $196,511
Funding Only Action P00006 · Role of mesenchymal stem cells in microgravity induced bone loss $133,036
Funding Only Action P00005 $100,000
Funding Only Action P00004 $163,036
Funding Only Action P00003 · Role of mesenchymal stem cells in microgravity induced bone loss $70,000
Funding Only Action P00002 $213,686
Other Administrative Action P00001 $0
Original award $35,000
Show all 12

About this award

Mayo Clinic Jacksonville, a nonprofit research institution and child organization of Mayo Clinic, was awarded a $1.09M research grant on December 1, 2020, with an ultimate completion date of January 31, 2027. The grant, funded by a civilian federal agency through the Shared Services Center, supports research investigating the effects of microgravity on bone health and homeostasis. Specifically, the research postulates that microgravity may decrease mesenchymal stem cell (MSC) numbers and disrupt the secretion of trophic factors that regulate bone formation and resorption, ultimately impairing bone homeostasis. This grant represents the type of advanced biomedical research for which Mayo Clinic Jacksonville is recognized, leveraging its extensive expertise in medical science and collaborative research capabilities.

The contract was awarded without a set-aside designation, indicating open competition. Work will be performed at Mayo Clinic Jacksonville's facility in Jacksonville, Florida, under the direction of Dr. Scott Lynch. This research aligns with Mayo Clinic Jacksonville's established portfolio of sophisticated research initiatives supported by federal agencies including the National Institutes of Health and Defense Health Agency, demonstrating the organization's capacity to conduct exploratory medical investigations addressing critical gaps in understanding physiological responses in extreme environments.

Description

Specifically, we postulate that microgravity may decrease MSC number and disturb the secretion of trophic factors that impede bone homeostasis by reducing new bone formation and/or increasing bone resorption in microgravity.

Quick answers

Who was awarded contract 80NSSC21K0299?

80NSSC21K0299 was awarded to Mayo Clinic Jacksonville (A Nonprofit Corporation) by Shared Services Center (National Aeronautics and Space Administration) on December 1, 2020.

How much is contract 80NSSC21K0299 worth?

The government has obligated $1,090,755 on 80NSSC21K0299.

Was contract 80NSSC21K0299 competed?

The extent of competition for 80NSSC21K0299 was full and open competition.

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