Synthesis of Non-GMP Small Molecules
Added: Nov 23, 2016 2:15 pm
Pre-Solicitation Notice: RFP No. N02CM77000-18Synthesis of Non-GMP Small MoleculesContracting Office AddressDepartment of Health and Human Services, National Institutes of Health (NIH), National Cancer Institute (NCI), Office of Acquisitions, Riverside Five, Suite 400, 8490 Progress Drive, Room 4025, Frederick, MD 21701-4998.Note: This synopsis follows a SBSS notice that was released on July 19, 2016 under HHS-NIH-NCI-SBSS-TSB-77000-18.DescriptionThe Development Therapeutics Program (DTP) of the National Cancer Institute's (NCI) Division of Cancer Treatment and Diagnosis (DCTD) is soliciting organizations with expertise in organic synthesis to perform re-synthesis of compounds needed for NCI Experimental Therapeutics (NExT) Program, other NCI/NIH (National Institutes of Health) programs and molecules arising from biological evaluations as potential anticancer agents.The Offerors shall be responsible for the synthesis of generally known small molecules in the chemical literature and/or their derivatives with minor modifications as requested by NCI, and their shipments to the NCI repository. The synthesis assignments will include synthesis of potential target anti-cancer agents of high purity and may include parallel synthesis of selected analogs. The Offerors shall prepare Material Safety Data Sheets for all single compounds and libraries which are delivered, and check the purities of compounds when requested.The NCI expects that 1 to 25 syntheses of compounds, both synthetics and natural products, will be synthesized each year during the contract period of five (5) years. Contractors must have a demonstrated ability, in the recent past, to carry out multi-step synthesis to routinely deliver up to 1,000 grams of the target compound and, on occasion, deliver up to 5,000 grams of the target compound.The solicitation is anticipated to result in up to three Indefinite Delivery/Indefinite Quantity (IDIQ) contracts with a five-year ordering period, awarded on or before May 20, 2016, to Offerors capable of performing all aspects of the work described in the Statement of Work (SOW). We anticipate task orders issued against the IDIQ contracts will be cost reimbursement and/or firm fixed price. The following mandatory qualification criteria will apply: As many of the compounds assigned for synthesis may be of a hazardous nature, the Contractor shall provide evidence of the necessary licenses required by the Local, State and Federal Governments to handle, synthesize, store and ship such compounds. The Contractors shall be in compliance with Environmental Protection Agency regulations regarding the discharge of water and air pollutants and for assuring that disposal of all chemical residues meet current EPA regulations.This is a recompetition of three IDIQ contracts, contract number HHSN261201200012C awarded to Alchem Laboratories Corp., HHSN261201200013C awarded to The Chemistry Research Solution LLC, and HHSN261201200014C awarded to Starks Associates Inc., each for a five-year period of performance.This advertisement does not commit the United States Federal Government to award any contract. The NAICS code for this acquisition is 325412 with a size standard of 1,250 employees. THIS ACQUISTION IS BEING ADVERTISED AS A TOTAL (100%) SET-ASIDE FOR SMALL BUSINESSES.The Request for Proposals (RFP) N02CM77000-18 solicitation is scheduled for electronic release on or about 12/5/2016 and receipt of proposals will be due at 3:00 pm ET on or about 1/5/2016. The RFP will only be available electronically and must be accessed through the Office of Acquisitions, NCI homepage by using the following address: http://rcb.cancer.gov/rcb-internet/ or through FedBizOpps.gov https://www.fbo.gov/. All information required for submission of a proposal will be contained in the electronic Request for Proposals (RFP) package. No collect calls will be accepted. No facsimile transmissions will be accepted. It is the offerors responsibility to monitor the above mentioned sites for release of the solicitation and any amendments. All responsible sources may submit a proposal, which shall be considered by the agency. POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE SOLICITIATION AND ANY AMENDMENTS THAT MAY BE ISSUED. Failure to do so will be at your firm's own risk.Points of contact: Carrie Mills, Contract Specialist at email carrie.mills@nih.govSecondary: Howard Cyrus, Contracting Officer at email cyrush@mail.nih.gov
N02CM77000-18 Department of Health and Human Services National Institutes of Health
11/23/16, 2:15 PM