Identification of biomarkers and pathological mechanisms via longitudinal analysis of neurological and cerebrovascular responses to neurotoxic stress using a multi-cellular integrated model of the…

Active Definitive Contract Awarded Last action

Contract number
80ARC022CA004
Awardee
Awarding agency
Obligated
$7,427,599

Award facts

Contract value 91% obligated
$8,202,930.23 Current and potential, with all options
Completion date 82% complete
Current and potential, with all options
Contracting staff
Set-aside
No set-aside
Competition
Full and Open Competition · 9 offers Basic Research
Pricing
Firm Fixed Price
Place of performance
New York, NY 10029, USA

Award details come from SAM.gov/FPDS.

Transactions

Action Obligated Date
Supplemental Agreement for work within scope P00009 $1,923,770
Supplemental Agreement for work within scope P00008 $3,510,846
Supplemental Agreement for work within scope P00007 $0
Funding Only Action P00006 $492,983
Other Administrative Action P00005 $0
Change Order P00004 $0
Funding Only Action P00002 $500,000
Funding Only Action P00003 $500,000
Supplemental Agreement for work within scope P00001 $0
Original award $500,000

About this award

NASA Ames Research Center awarded a $8.2 million definitive contract to Icahn School of Medicine at Mount Sinai on September 28, 2022, for identification of biomarkers and pathological mechanisms via longitudinal analysis of neurological and cerebrovascular responses to neurotoxic stress using a multi-cellular integrated model of the human brain, with a firm fixed price structure and completion date of September 29, 2027.

The originating solicitation, posted May 27, 2021, sought proposals from the research community to develop 3D tissues and microphysiological systems with extended longevity of at least six months to model acute and chronic exposures to stressors. The multi-agency effort, coordinated by NASA, NIH, HHS BARDA, and FDA, anticipated total funding of $12 million to $20 million distributed across 6 to 10 awards. Individual awards were structured at up to $500,000 per year for four years, totaling $2 million per award, with evaluation based on technical merit and relevance to prolonged stressor modeling.

Place of performance is New York, NY. Work is conducted under NAICS code 541715 and PSC code R425.

Service Contract Inventory reporting shows actual government-invoiced labor across the contract's performance: FY2023 invoiced $498 thousand across 2.7 FTEs and 5,648 contractor hours (derived rate $88.21/hr); FY2024 invoiced $498 thousand across 2.5 FTEs and 5,121 contractor hours (derived rate $97.30/hr); FY2025 invoiced $498 thousand across 2.3 FTEs. No subcontractors were engaged; Mount Sinai self-performed all reported hours.

Description

Identification of biomarkers and pathological mechanisms via longitudinal analysis of neurological and cerebrovascular responses to neurotoxic stress using a multi-cellular integrated model of the human brain

Quick answers

Who was awarded contract 80ARC022CA004?

80ARC022CA004 was awarded to Icahn School Of Medicine At Mount Sinai by Ames Research Center (National Aeronautics and Space Administration) on September 28, 2022.

How much is contract 80ARC022CA004 worth?

The government has obligated $7,427,599 on 80ARC022CA004. Its current value, with exercised options, is $8,202,930.

Was contract 80ARC022CA004 competed?

The extent of competition for 80ARC022CA004 was full and open competition. The government received 9 offers.

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