Immune mechanisms of protection against mycobacterium tuberculosis center (IMPAC-TB)

Active Definitive Contract Awarded Last action

Contract number
75N93019C00070
Awardee
Awarding agency
Obligated
$90,532,553

Award facts

Opportunity
Contract value 100% obligated
$90,532,553.00 Current and potential, with all options
Completion date 89% complete
Current and potential, with all options
Set-aside
No set-aside
Competition
Full and Open Competition · 12 offers Negotiated Proposal / Quote
Pricing
Cost No Fee
Place of performance
Seattle, WA 98101, USA
Legislative mandates

Award details come from SAM.gov/FPDS.

Transactions

Action Obligated Date
Change Order P00026 · EO14398. Immune mechanisms of protection against mycobacterium tuberculosis consortium. $3,934,592
Other Administrative Action P00025 $0
Change Order P00024 $4,805,147
Other Administrative Action P00023 $0
Other Administrative Action P00022 $0
Exercise an Option P00021 $15,303,236
Other Administrative Action P00020 $0
Other Administrative Action P00019 $0
Other Administrative Action P00018 $0
Exercise an Option P00017 $14,317,798
Other Administrative Action P00016 $0
Other Administrative Action P00015 $0
Other Administrative Action P00014 $0
Other Administrative Action P00013 $0
Other Administrative Action P00012 $0
Change Order P00011 $13,601,743
Other Administrative Action P00010 $0
Other Administrative Action P00009 $0
Other Administrative Action P00008 $0
Other Administrative Action P00007 $0
Exercise an Option P00006 $13,001,420
Other Administrative Action P00005 $0
Funding Only Action P00004 $554,910
Other Administrative Action P00003 $0
Exercise an Option P00002 $11,541,977
Modification $13,471,730
Other Administrative Action P00001 $0
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About this award

The National Institute of Allergy and Infectious Diseases awarded a $90.532 million definitive contract to Seattle Children's Hospital (doing business as Seattle Children's Research Institute) for the Immune Mechanisms of Protection Against Mycobacterium Tuberculosis Center (IMPAC-TB) on September 30, 2019, with ultimate completion September 29, 2027, under cost-no-fee pricing and no set-aside.

Place of performance is Seattle, WA 98101. The originating solicitation and Executive Order 14398 direct the consortium to identify immune responses capable of controlling or eradicating Mycobacterium tuberculosis through integrated analyses of tissue-specific and systemic immunity across mice, non-human primates, and humans, informing rational TB vaccine design. The multi-institutional research effort operates as a coordinating center spanning domestic and international locations, with primary subcontractors including Oregon Health & Science University, University of Washington, Fred Hutchinson Cancer Center, University of Massachusetts, Beth Israel Deaconess Medical Center, Stellenbosch University (South Africa), University of Minnesota, University of Alabama at Birmingham, Africa Health Research Institute (South Africa), London School of Hygiene and Tropical Medicine (UK), and Akagera Medicines. Work encompasses household contact studies, bronchoscopy coordination, human immunologic studies, non-human primate vaccine efficacy testing, mouse model development, transcriptomics and epigenetic analysis, spatial imaging of lung granulomas, and data resource management across seven fiscal years.

Service Contract Inventory reporting shows FY2025 invoiced labor of $14.6 million across 56.2 FTEs and 116,857 contractor hours, with a blended government-paid rate of $124.92 per hour. Subcontractors accounted for 85 percent of contractor hours in FY2025 across 24 named partners. Invoiced amounts rose from $2.7 million (FY2020) to $14.6 million (FY2025), reflecting the multi-year research consortium's growing operational scale.

Subawards

Subcontractor Amount Awarded
Oregon Health & Science University IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) Statement of Work – Year 7 (Base) The overall goal of the Oregon Health &… $410,118
University Of Massachusetts IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) The purpose of this subaward is to study how the baseline state and… $96,078
Beth Israel Deaconess Medical Center, Inc. IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) Statement of Work – Year 7 (Base) – Barouch Lab During the preceding… $287,574
University Of Washington IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) Statement of Work – Year 7 (Base) – Hawn The Hawn laboratory at the… $116,224
Stellenbosch University IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) Statement of Work – Year 7 (Base) The du Plessis/Walzl laboratory at… $422,035
Regents Of The University Of Minnesota IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) Statement of Work – Year 7 (Base) – Gale The Gale laboratory will perform… $394,857
Fred Hutchinson Cancer Center IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) In Year 7, the Edlefsen group at Fred Hutchinson Cancer Center (Fred Hutch)… $230,009
University Of Washington IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) Statement of Work – Year 7 (Base) – Gerner The Gerner laboratory at the… $335,085
Oregon Health & Science University IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) The overall goal of the Oregon Health & Science University (OHSU) program… $383,461
Fred Hutchinson Cancer Center IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) This Statement of Work (SOW) outlines the activities that Fred Hutchinson… $281,067
Regents Of The University Of Minnesota IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) The overall goal of the IMPAc-TB program is to inform the rational design… $601,068
University Of Washington IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) This Statement of Work (SOW) outlines the activities that University of… $415,041
Beth Israel Deaconess Medical Center, Inc. IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) This Statement of Work (SOW) outlines the activities that University of… $363,812
Africa Health Research Institute NPC IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) Africa Health Research Institute (AHRI) will conduct global molecular… $936,063
Africa Health Research Institute NPC IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) Africa Health Research Institute (AHRI) will conduct global molecular… $24,716
University Of Alabama At Birmingham IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) This Statement of Work (SOW) outlines the activities that University of… $116,328
University Of Alabama At Birmingham IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) Under this subaward, Dr. Wong (an Assistant Professor at the University… $69,798
Oregon Health & Science University IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) Under this Option we will conduct studies in RM to validate the efficacy of… $7,999,044
University Of Massachusetts IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) The purpose of this subaward is to study how the baseline state and… $108,692
Akagera Medicines Inc. IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) Statement of Work: Defining the role of CD8 T cells induced by a novel… $107,341
Stellenbosch University IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) The du Plessis/Walzl laboratory at Stellenbosch University (SU) will be… $603,912
Regents Of The University Of Minnesota IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) Option Sample and Data 6 – Gale The overall goal of the IMPAc-TB… $154,513
University Of Washington IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) This Statement of Work (SOW) outlines the activities that University of… $287,023
University Of Washington IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) This Statement of Work (SOW) outlines the activities that University of… $150,000
University Of Washington IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) Currently planned studies using 13-plex microscopy can provide insight into… $279,995
University Of Washington IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) The overall goal of the IMPAc-TB program is to inform the rational design… $787,666
University Of Washington IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) The overall goal of the IMPAc-TB program is to inform the rational design… $150,861
Beth Israel Deaconess Medical Center, Inc. IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) Research efforts during Years 1 through 4 resulted in major findings… $365,976
University Of Washington IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) The Gerner laboratory at the University of Washington (UW) School of… $410,758
Stellenbosch University IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) The Walzl laboratory at Stellenbosch University (SU) will be responsible… $570,036
London School Of Hygiene And Tropical Medicine IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) The scope of this subaward is to isolate cells from the tissues of deceased… $499,937
University Of Massachusetts IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) The purpose of this subaward is to study how the baseline state and… $58,629
Oregon Health & Science University IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) Rationale: Option 4 was originally devised as a placeholder experiment to… $7,486,117
Oregon Health & Science University IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) The overall goal of the Oregon Health & Science University (OHSU) program… $703,618
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Quick answers

Who was awarded contract 75N93019C00070?

75N93019C00070 was awarded to Seattle Children's Hospital by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on September 30, 2019.

How much is contract 75N93019C00070 worth?

The government has obligated $90,532,553 on 75N93019C00070.

Was contract 75N93019C00070 competed?

The extent of competition for 75N93019C00070 was full and open competition. The government received 12 offers.

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