Carb-X global antibacterial accelerator OTA

Active Definitive Contract Awarded Last action

Contract number
75A50122C00028
Awardee
Awarding agency
Obligated
$150,780,000

Award facts

Opportunity
Contract value 50% obligated
  • $150,780,000.00 Current, with exercised options
  • $300,000,000.00 Potential, with all options
Completion date 44% complete
  • Current, with exercised options
  • Potential, with all options
Set-aside
No set-aside
Competition
Full and Open Competition · 3 offers Negotiated Proposal / Quote
Pricing
Cost No Fee
Place of performance
Boston, MA 02215, USA
Legislative mandates

Award details come from SAM.gov/FPDS.

Transactions

Action Obligated Date
Exercise an Option P00009 $10,780,000
Change Order P00008 · Carb-X global antibacterial accelerator OTA - update period of performance $0
Exercise an Option P00007 · Carb-X global antibacterial accelerator OTA - exercise option 3 $33,000,000
Exercise an Option P00006 $22,000,000
Change Order P00005 $0
Supplemental Agreement for work within scope P00004 · Carb-X global antibacterial accelerator OTA - add funds $20,000,000
Exercise an Option P00003 $40,000,000
Supplemental Agreement for work within scope P00002 $5,000,000
Other Administrative Action P00001 $0
Original award $20,000,000

About this award

The Office of the Assistant Secretary for Preparedness and Response awarded a $300 million definitive contract to Trustees of Boston University for the CARB-X Global Antibacterial Accelerator OTA on June 1, 2022, under a cost-no-fee pricing structure with an ultimate completion date of May 31, 2032.

The contract operates as an Other Transaction Agreement (OTA) with no set-aside designation. Place of performance is Boston, MA. The originating solicitation describes a Broad Agency Announcement from the Biomedical Advanced Research and Development Authority seeking proposals for advanced research and development of medical countermeasures against biological and pandemic threats, including vaccines, therapeutics, and diagnostics. BARDA anticipated multiple awards ranging from $750,000 to $8 million depending on project scope.

The contract funds a global antibacterial accelerator supporting multiple product developers advancing antimicrobial resistance countermeasures. Subcontractors and sub-awardees span diverse modalities: vaccine developers (Glaxosmithkline Biologicals, GlyProVac, Vaxdyn, Lumen Bioscience, Seres Therapeutics, Baxiva, Centauri Therapeutics, Immunartes, Clarametyx Biosciences, Limmatech Biologics), small-molecule antibiotic developers (Kinvard Bio, Helmholtz-Zentrum für Infektionsforschung, Basilea Pharmaceutica, Arrepath, Mutabilis), diagnostic companies (Day Zero Diagnostics, Chembio Diagnostic Systems, Uh-Oh Labs, Pearl Diagnostics, Prompt Diagnostics, Visby Medical, Zeteo Tech, Quantamatrix, Astradx, Meliolabs), bacteriophage and biotherapeutic developers (Locus Biosciences, Snipr Biome, Vedanta Biosciences, Peptilogics, Cellics Therapeutics), and accelerator and support organizations (Centre for Cellular and Molecular Platforms, Foundation for Innovative New Diagnostics, Institute for Life Science Entrepreneurship). Academic partners include Harvard College, Duke University, University of Alabama at Birmingham, Rhode Island Hospital, University of Oxford, University of Maryland Baltimore, Jackson Laboratory, and University of Melbourne. The contract supports development across infectious disease domains including gonorrhea, chlamydia, Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, and other multidrug-resistant pathogens.

Subawards

Subcontractor Amount Awarded
Entasis Therapeutics, Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA This project supports the early development of ETX1791, a new investigational antibiotic designed to treat serious… $269,501
Subcontractor not on record CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Gonorrhea is a sexually transmittable disease that is caused by infection with Neisseria gonorrhoeae bacteria… $800,000
President And Fellows Of Harvard College CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA The Myers Lab has developed platform technology for the rapid chemical synthesis of potent inhibitors of the… $796,464
Chembio Diagnostic Systems Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA The objective of the proposed program is to develop an accurate rapid point-of-care (POC) test for IgA antibody… $1,008,228
Uh-Oh Labs Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA The key goal of this program is to develop a design-locked version of STI Scout, an in vitro diagnostic (IVD) for… $1,250,000
University Of Alabama At Birmingham CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA This study is intended to aid in the development and clinical evaluation of rapid nucleic acid- based tests for… $249,000
Subcontractor not on record CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA This research program will evaluate the potential of breath analysis as a novel, noninvasive diagnostic approach for… $194,295
Subcontractor not on record CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Diagnosis of lower respiratory tract infections (LRTls) often relies on sample types such as bronchoalveolar… $248,997
Seres Therapeutics, Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Seres is developing a novel Live Biotherapeutic Product (LBP) of human commensal bacteria formulated for oral liquid… $895,707
Zeteo Tech, Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA The proposed research focuses on evaluating a noninvasive diagnostic platform that uses exhaled breath to diagnose… $247,988
Quantamatrix Incorporated CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA QMAP (Quick Multiplexed Assay Platform) is a cheap, fast, accurate, and highly scalable fully automated system for… $998,055
Subcontractor not on record CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Baxiva aims to develop a next-generation glycoconjugate vaccine targeting Escherichia coli to address the urgent… $302,677
Subcontractor not on record CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA PHIOGEN’s mission is to explore the microbial world for bacteriophages with novel therapeutic potential. Our… $439,033
Kinvard Bio, Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Kinvard Bio aims to build upon research from the laboratory of Pr. Andy Myers at Harvard University which has… $452,265
Centauri Therapeutics LIMITED CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Centauri is a privately-owned biotech company developing novel immunotherapeutics to treat life-threatening… $1,805,406
Arrepath Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA The overall goal of this project is to develop an IV + oral agent with a novel mechanism of action (MOA) for the… $931,866
Helmholtz-Zentrum Fuer Infektionsforschung GMBH CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Hospital-acquired pneumonia caused by the bacterial pathogen Staphylococcus aureus is associated with high… $517,343
Duke University CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA The Oh lab at Duke University will develop and validate a metagenomic pipeline for pathogen detection and… $245,400
Rhode Island Hospital CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Pneumonia is a common clinical diagnosis that often lacks a microbiological diagnosis because no pathogen is… -$99,937
Uh-Oh Labs Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA The key goals of this program are to demonstrate detection of gonorrhea from crude vaginal swab and urine samples… $44,117
Peptilogics Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Peptilogics is a biotechnology company that utilizes an innovative platform to develop novel peptide therapeutics to… -$326,200
President And Fellows Of Harvard College CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA The Myers laboratory extensively redesigns natural antibiotic sca¿olds then prepares them by chemical synthesis… -$232,664
Justus-Liebig-Universität Giessen CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Our project aims to develop a new drug effective against multidrug-resistant (MDR) Gram-negative bacteria. Our early… -$61,028
Helmholtz-Zentrum Fuer Infektionsforschung GMBH CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA In this CARB-X project, we aim at developing our novel class of compounds targeting the bacterial sliding clamp… $500,000
Glaxosmithkline Biologicals CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Strep A is a Gram-positive bacterium with a rich repertoire of virulence factors that allows for a wide spectrum… $1,758,513
Day Zero Diagnostics Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Day Zero Diagnostics is developing a culture-free, sequencing-based diagnostic that identifies within hours both the… $1,499,992
Astradx Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA The proposal is to perform targeted feasibility studies supporting efforts to develop and bring to market a… $543,078
Subcontractor not on record CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA The goal of this project is to complete phase 1 clinical trials with a new vaccine formulation that prevents… $65,188
Pearl Diagnostics, Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Pearl Diagnostics Inc. (PearlDx) develops novel in vitro diagnostic (IVD) tests that aid non-invasive diagnosis of… $750,000
Meliolabs Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Melio is committed to revolutionizing the healthcare industry by offering rapid infectious disease diagnostic… $1,436,243
Justus-Liebig-Universität Giessen CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Our project aims to develop a new drug effective against multidrug-resistant (MDR) Gram-negative bacteria. Our early… $335,651
Rhode Island Hospital CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Pneumonia is a common clinical diagnosis that often lacks a microbiological diagnosis because no pathogen is… $549,654
Clarametyx Biosciences, Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Urinary tract infections (UTIs) are an increasing clinical problem, having increased by 60% between 1990 and 2019… $384,727
Immunartes, LLC CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Immunartes is developing a monoclonal antibody as a preventative to combat Staphylococcus aureus, a leading cause of… $249,838
Locus Biosciences Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Locus Biosciences is a clinical-stage biopharmaceutical company developing antibacterial therapies using… -$400,000
Peptilogics Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Peptilogics is a biotechnology company that utilizes an innovative platform to develop novel peptide therapeutics to… $1,520,300
Helmholtz-Zentrum Fuer Infektionsforschung GMBH CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA In this CARB-X project, we aim at developing our novel class of compounds targeting the bacterial sliding clamp… -$200,000
Subcontractor not on record CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA This project is focussed on developing and characterising assays for Chlamydia (CT) and Gonorrhoea (NG) that are… -$100,000
Uh-Oh Labs Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA The key goals of this program are to demonstrate detection of gonorrhea from crude vaginal swab and urine samples… -$200,000
Jackson Laboratory CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA As part of a program sponsored by CARB-X to help define an evidence-based clinical development framework for the… -$249,324
Duke University CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Dr. Vance Fowler and Dr. Will Woodhouse of Duke University will be supporting a systematic review project… $95,123
Locus Biosciences Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Locus Biosciences is a clinical-stage biopharmaceutical company developing antibacterial therapies using… $1,026,565
Cellics Therapeutics Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Sepsis remains a significant medical challenge with no effective treatment available. This project is to develop a… $644,577
Jackson Laboratory CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA As part of a program sponsored by CARB-X to help define an evidence-based clinical development framework for the… $249,324
Prompt Diagnostics, Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Prompt Diagnostics LLC (Prompt) is developing a PCR platform that will streamline sample-to-answer STI… $299,993
University Of Maryland, Baltimore CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Klebsiella pneumoniae is a major cause of hospital-acquired infections and has recently been recognized as a leading… $792,000
Subcontractor not on record CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA This project is focussed on developing and characterising assays for Chlamydia (CT) and Gonorrhoea (NG) that are… $400,000
Basilea Pharmaceutica International Ltd, Allschwil CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Infections caused by multidrug-resistant bacteria have become one of the most important threats to global health,… $9,053,709
Day Zero Diagnostics Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA Day Zero Diagnostics is developing a culture-free, sequencing-based diagnostic that identifies within hours both the… $622,358
Uh-Oh Labs Inc. CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA - ADD FUNDS The key goals of this program are to demonstrate detection of gonorrhea from crude vaginal swab and… $400,000
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Quick answers

Who was awarded contract 75A50122C00028?

75A50122C00028 was awarded to Trustees Of Boston University by Office of the Assistant Secretary for Preparedness and Response (Department of Health and Human Services) on June 1, 2022.

How much is contract 75A50122C00028 worth?

The government has obligated $150,780,000 on 75A50122C00028. Its potential value, with all options, is $300,000,000.

Was contract 75A50122C00028 competed?

The extent of competition for 75A50122C00028 was full and open competition. The government received 3 offers.

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