Deobligate and close out the contract

Ended Definitive Contract Awarded Last action

Contract number
75A50118C00015
Awardee
Awarding agency
Obligated
$49,196,134

Award facts

Opportunity
Contract value 100% obligated
$49,196,133.50 Current and potential, with all options
Completion date 100% complete
Current and potential, with all options
Contracting staff
Set-aside
No set-aside
Competition
Full and Open Competition · 1 offer Negotiated Proposal / Quote
Pricing
Cost Sharing
Place of performance
Cambridge, MA 02139, USA
Legislative mandates

Award details come from SAM.gov/FPDS.

Transactions

Action Obligated Date
Funding Only Action P00022 -$537,178
Supplemental Agreement for work within scope P00021 · Modification P00021 this modification is being issued to DE-obligate cancelling funds in the amount of $61,887.86. -$61,888
Other Administrative Action P00020 · Modification P00020 the purpose of this bilateral modification is to: a) update article G.2. Contracting officer?S representative (COR). $0
Supplemental Agreement for work within scope P00019 · Modification P00019 the purpose of this bilateral modification is to: a) change article F.2. Deliverables, article G.2. Contracting officer's representative… $6,422,390
Supplemental Agreement for work within scope P00018 · The purpose of this bilateral modification P00018 is to: a) change clin 0002 option 1?S cost share portion to increase spero?S share from $161,178.00 by… $0
Supplemental Agreement for work within scope P00017 · The purpose of this bilateral modification P00017 is to: a) change the key personnel listed in article G.3 key personnel as follows: 1. Change timothy keutzer's… $0
Other Administrative Action P00016 · Modification P00016 the purpose of this unilateral modification is to: a) correct the period of performance end date of clin 0002 to 12/31/2025 per the agreed… $0
Supplemental Agreement for work within scope P00015 · Modification P00015 the purpose of this bilateral modification is to: a) increase the US government funding for clin 0005 option 4 from $12,498,467 by… $11,697,110
Supplemental Agreement for work within scope P00014 · Advance the development of SPR994 as an oral therapy for use in adults to treat complicated urinary tract infections (CUTIS), including those caused by drug… $641,630
Supplemental Agreement for work within scope P00013 · This no cost bilateral modification is for a no cost extension for clin 0002. $0
Other Administrative Action P00012 · This no cost bilateral modification to amend the key personnel section within the contract. DR. Akash jain will replace erin wenzel as director alliance… $0
Other Administrative Action P00011 · This MOD is to revise the POP for clin 2 to reflect DEC 31,2023 in order for the vendor to process invoices in the IPP system. $0
Other Administrative Action P00010 · This MOD is to revise SOW for clin 2 to reflect the new development plan for tebipenenem HBR following FDA feedback at the type a meeting, as well as the… $0
Funding Only Action P00009 · This MOD should include updated SOW, go/no-go milestones, gantt chart) change the CO from kathy to jonathan gonzalez; change key personnel CMO from david to… $12,498,467
Supplemental Agreement for work within scope P00008 -$12,498,467
Other Administrative Action P00007 · Change COR $0
Exercise an Option P00006 · Exercise option 3/CLIN0004 $12,900,000
Supplemental Agreement for work within scope P00005 · Provide a NCE through 12/15/2022; incorporate covid-19 language; update SOW $0
Other Administrative Action P00004 · Change key personnel and update related article $0
Supplemental Agreement for work within scope P00003 $0
Exercise an Option P00002 · Exercise of option 1 (clin 0002) $0
Supplemental Agreement for work within scope P00001 $2,476,034
Original award Development of SPR994 an oral carbapenem for the treatment of drug resistant gramnegative bacterial $15,658,035
Show all 23

About this award

Written by GovTribe AI ·

The Office of the Assistant Secretary for Preparedness and Response (ASPR) awarded a definitive contract to Spero Therapeutics, Inc. for development of SPR994, an oral carbapenem for treatment of drug-resistant gram-negative bacterial infections, with a ceiling value of $49.7 million and an ultimate completion date of October 31, 2026. The contract is cost-shared and carries no set-aside.

Work is performed in Cambridge, MA. The contract originated from a Broad Agency Announcement posted by the Biomedical Advanced Research and Development Authority (BARDA) on October 16, 2017, seeking advanced research and development of medical countermeasures against chemical, biological, radiological, nuclear, and pandemic influenza threats. The solicitation anticipated multiple awards ranging from $750,000 to $8 million with periods of performance tied to development milestones and FDA approval or licensure objectives.

Most recent government-invoiced activity (FY2024) reflects 0.2 FTEs and 333 contractor hours with a derived hourly rate of $44,557.30 per hour, with Spero Therapeutics self-performing all reported hours. The contract has experienced a significant rise in derived hourly rates over its multi-year performance, from $2,350.03 per hour in FY2021 (when 2.7 FTEs and 5,677 contractor hours were invoiced at $13.3 million) to the FY2024 rate, reflecting a shift toward higher-value technical and regulatory milestones in the drug development lifecycle. Modification P00021 de-obligated $61,887.86.

Quick answers

Who was awarded contract 75A50118C00015?

75A50118C00015 was awarded to Spero Therapeutics, Inc. by Office of the Assistant Secretary for Preparedness and Response (Department of Health and Human Services) on July 12, 2018.

How much is contract 75A50118C00015 worth?

The government has obligated $49,196,134 on 75A50118C00015.

Was contract 75A50118C00015 competed?

The extent of competition for 75A50118C00015 was full and open competition. The government received 1 offer.

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