Intelligent Imaging Innovations, Inc.

Intelligent Imaging Innovations, Inc., doing business as 3 I, is a for-profit manufacturer of advanced microscopy equipment and software located in Denver, Colorado. The company specializes in providing sophisticated imaging systems and related technologies to federal research agencies, with a primary focus on biomedical and scientific research applications. Registered in SAM.gov since 2001, 3 I has established itself as a key supplier of cutting-edge microscopy solutions to various government agencies, particularly within the National Institutes of Health (NIH) ecosystem.

The company has secured numerous federal contract awards across multiple agencies, primarily focusing on the procurement and maintenance of specialized microscopy systems. These contracts include the delivery of advanced imaging technologies such as Lattice Light Sheet microscopes, TIRF3 microscopy systems, Marianas Super-Resolution Spinning Disk Confocal Microscopy Systems, and associated hardware like EMCCD cameras and computer workstations. Notable federal agency customers include the National Cancer Institute, National Institute on Drug Abuse, National Heart, Lung, and Blood Institute, and the National Institute on Deafness and Other Communication Disorders. Most of these contracts were awarded on a non-set-aside basis, with a few exceptions like a NASA Small Business Technology Transfer (STTR) Phase II contract valued at $749,527 for the "REALISE - Remote Experimentation and Analysis Laboratory in Space" project. The company has also performed sub-contract work for entities like Leidos Biomedical Research Inc., providing microscopy systems and solutions.

In the realm of federal grant awards, 3 I has secured a significant grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program. This $505,311 project grant, awarded in January 2025, aims to develop a commercial instrument for large-scale, all-optical electrophysiology. The two-year project seeks to create a technology that can simultaneously record from thousands of neurons and selectively activate optogenetically-labeled neurons across multiple brain regions. The grant aligns with NIMH's mission to transform understanding and treatment of mental illnesses through innovative research. The project involves in vitro evaluation and preliminary in vivo experiments, conducted in collaboration with research laboratories at the University of Colorado Anschutz Medical Campus, leveraging 3 I's expertise in advanced microscopy technologies and computer-generated holography for neural stimulation.