Cvpath Institute Inc.

Cvpath Institute Inc. is a non-profit organization specializing in cardiovascular pathology services for federal government research initiatives. Registered in SAM.gov since July 2006, the institute is primarily focused on supporting efforts to improve cardiovascular care, particularly for veterans. Cvpath Institute maintains a comprehensive sudden cardiac death registry and offers expertise in processing and analyzing human coronary artery samples for various research projects. Their work contributes significantly to the understanding and treatment of severe coronary artery disease through detailed histopathological analysis and specialized tissue sample processing.

Through federal contract awards, Cvpath Institute provides cardiovascular pathology services to the Department of Veterans Affairs Veterans Health Administration. These services include processing tissue samples, producing slides with specialized staining, and digitizing slides to aid studies aimed at improving cardiovascular care for veterans. Recent contract awards from the Veterans Integrated Service Network 19 have involved delivery orders for research support, with contract values around $10,500 and performance periods of approximately one year. The work is typically performed at Cvpath Institute's location in Potomac, Maryland, and does not involve any specific set-aside designations. These contracts support VA-funded research efforts by providing consistent and high-quality pathology services across multiple research sites.

Cvpath Institute has received multiple federal grant subawards, primarily in collaboration with the University of Virginia. These subawards support research on progressive coronary plaques and involve selecting and providing phenotyped human coronary artery samples from Cvpath's sudden cardiac death registry. The institute selects 20-24 stable or unstable plaques annually, including various types of lesions such as ruptures, thin-cap fibroatheromas, and fibroatheromas. Cvpath evaluates approximately 25 autopsy cases of sudden coronary deaths each year, performing histopathology, immunostaining, and selecting suitable plaques for further analysis. The work contributes to studies on smooth muscle cells, macrophage characterization, and gene analyses, with a focus on improving understanding of severe coronary artery disease. These grant-funded projects often involve collaboration with university researchers, providing them with specialized samples and analyses to support their cardiovascular studies.

Cvpath Institute holds an indefinite delivery contract (IDC) awarded by the Department of Veterans Affairs Veterans Health Administration Veterans Integrated Service Network 19. This single-award IDC, with a ceiling value of $42,048 and a performance period from March 2023 to March 2025, covers cardiovascular pathology services in support of VA-funded research efforts. Under this contract, Cvpath processes tissue samples from five research sites, performing tasks such as gross examination, digital imaging, slide production with specialized staining, digitization of slides with region-of-interest marking, and histology validation. This IDC enables the VA to efficiently procure Cvpath's specialized services for ongoing and future cardiovascular research projects aimed at improving care for veterans. The contract's structure allows for flexible and responsive support to various VA research initiatives, ensuring consistent and high-quality pathology services across multiple studies.