Space Operations
Active
- Assistance listing
- 43.007
- Grant awards
- 568 $544,890,852 in federal obligations
Program facts
- Assistance types
-
- Cooperative Agreement
- Project Grant
- Treasury account
-
- 80-0115-0-1-252
- More information
Program details come from SAM.gov Assistance Listings. Updated . Grant award figures come from USAspending.gov.
About this program
The National Aeronautics and Space Administration (NASA) Space Operations Mission Directorate funds research, technology development, and operational support enabling human spaceflight, International Space Station (ISS) operations, crew health countermeasures, and space communications through CFDA 43.007, with the most recent grant award dated March 20, 2026.
The program predominantly funds human health and performance research for spaceflight. Recent awards have focused on space radiation effects and mitigation (radiation carcinogenesis, biodosimetry for brain DNA instability and neurodegenerative changes), countermeasures for microgravity-induced physiological changes (bone loss, muscle atrophy, neuro-ocular syndrome, cardiovascular dysfunction), crew behavioral health and performance during isolation and communication latency, ISS National Laboratory management, and supporting technologies such as communications systems and materials science experiments on the ISS. Additional funding supports educational initiatives, scientific infrastructure, and crew training systems.
The assistance-type mix is predominantly Project Grants (81% of 568 awards) with a smaller share of Cooperative Agreements (19%). Funding concentration is high among NASA internal centers: the NASA Shared Services Center leads by award count with 398 awards totaling $208.2 million in federal dollars; NASA Johnson Space Center dominates by federal dollars with 8 awards totaling $282.4 million; and the central NASA organization holds 155 awards for $51.5 million. The remaining funding is distributed across NASA Glenn Research Center and NASA Goddard Space Center. Combined federal obligation across all 568 awards totals $544.9 million.
Recent activity shows variable award volume. After 22 awards in 2024, the pace slowed to 9 awards in 2025 and 4 through March 2026. Representative recent awards include in-space manufacturing of engineered liver tissue via Cooperative Agreement for $2.9 million (Wake Forest Institute), neurobehavioral changes following radiation and stress for $1 million (Project Grant), ISS National Laboratory management for $3 million (Cooperative Agreement), and crew adaptive decision-making research for $215 thousand. Award sizes typically range from tens of thousands of dollars for focused efforts to several million for multi-year development projects.
Multiple open grant opportunities are currently active. NASA's 2025 Human Exploration Research Opportunities (HERO) NOFO (NNJ25ZSA001N) remains open through October 31, 2025, and covers five research elements (Space Radiation, Human Health Countermeasures, Exploration Medical Capability, Human Factors and Behavioral Performance, Research Operations and Integration) with awards generally ranging from under $250 thousand to $1.2 million annually. The omnibus component (NNJ25ZSA001N-OMNIBUS) has a December 2, 2024 Step-1 deadline for early-career and novel-idea proposals lasting no more than one year. NSF partnerships with the Center for the Advancement of Science in Space are also active: Transport Phenomena Research at the ISS (due March 4, 2026) and Tissue Engineering and Mechanobiology at the ISS (due March 18, 2025) both restrict applicants to U.S. persons and academic, non-profit, or commercial teams.
Objective and description
- Objective
NASA's Space Operations Mission Directorate ensures continued American leadership in low Earth orbit, encourages economic growth of the commercial space sector, enables continued and successful access to space, and provides a foundation for deep spac
- Description
NASA's Space Operations Mission Directorate maintains a continuous human presence in space for the benefit of people on Earth. The programs within the directorate are the hub of NASA's space exploration efforts, enabling Artemis, commercial space, science, and other agency missions through communication, launch services, research capabilities, and crew support.
Eligibility
- Applicant eligibility
Categories of organizations that may be eligible for NASA grants and cooperative agreements include: • Institutions of Higher Education (IHE) - A two- or four-year university or college (including U.S. community colleges), public or private, accredited to confer degrees beyond that of the K-12 grade levels. 29 • Educational Institutions - Non-higher-education entities, such as K-12 education groups or institutions of informal education, are classified as Educational Institutions.2 • Non-profit Organization - An organization that: o Is operated primarily for scientific, engineering, educational, research, or similar purposes in the public interest; o Is not organized primarily for profit; o Uses net proceeds to maintain, improve, or expand the organization's operations; and o Is not an IHE. Non-profit organizations generally exclude (i) colleges and universities; (ii) hospitals; and (iii) state, local, and Federally recognized Indian tribal governments. • For-profit Entity - An organization of any size that is organized primarily for profit. • Federally Funded Research and Development Center (FFRDC) - FFRDCs are under a broad charter by a Government agency for performing, analyzing, or conducting research for the United States Government. NASA sponsors JPL as the Agency's sole FFRDC, and JPL is not an eligible applicant to receive a NASA-funded grant or cooperative agreement as a recipient or subrecipient3 . However, FFRDCs sponsored by agencies other than NASA may be eligible to receive a NASA-funded award as a recipient or subrecipient. • Non-U.S. Organizations - Organizations outside the U.S. that meet the definitions of foreign organization or foreign public entity in 2 CFR § 200.1. Non-U.S. organizations generally propose for opportunities on a no-exchange-of-funds basis in accordance with NASA policy. NOFOs may be issued jointly with a non-U.S. organization (e.g., those concerning guest observing programs for jointly sponsored space science programs) that will contain additional special guidelines for non-U.S. participants. • State, Local, or Federally-Recognized Tribal Government Agency - o State Government means any state of the United States, the District of Columbia, the Commonwealth of Puerto Rico, any territory or possession of the United States, and any agency or instrumentality of a State exclusive of its local governments
- Uses of assistance
Grant funding may be used to support basic research, educational outreach, and training opportunities related to space operations Applicants should carefully review the applicable Notice of Funding Opportunity (NOFO) for detailed information on allowable activities, program priorities, eligibility requirements, funding restrictions, and any limitations or conditions that may apply to the use of funds.
- Use restrictions
Restrictions on the use of assistance for this listing are governed by the limitations and conditions set forth in NASA's Grant and Cooperative Agreement Manual (GCAM). The GCAM includes a dedicated section on limitations and restrictions, which outlines the circumstances under which funds may not be used. Applicants and recipients should refer to the applicable GCAM limitations provisions, in conjunction with the specific Notice of Funding Opportunity (NOFO), to understand any restrictions that apply. Only restrictions that are unique to this Assistance Listing or organization are identified here; all other standard limitations apply as described in the GCAM.
- Length and time phasing of assistance
Generally, up to three years but no more than five years. Applicants should review funding opportunity announcement for additional information.
How to apply
- Preapplication coordination
Applicants must follow the proposal submission instructions outlined in the applicable Notice of Funding Opportunity (NOFO). Specific submission requirements-including whether a Notice of Intent (NOI) and/or Phase I proposals are required-are defined in the individual funding opportunity announcement and may vary by program. In addition, all Principal Investigators (PIs) and Co-Investigators (Co-Is) must register in NASA's Solicitation and Proposal Integration and Review System (NSPIRES) at https://nspires.nasaprs.com/external as NSPIRES is used to support proposal submission, review, and award processing.
- Criteria for selecting proposals
All proposals will undergo an administrative, merit, and financial review. The NASA funding organization responsible for managing the technical aspects of an awarded effort is responsible for the merit review process, which may be based on peer review. All applications for NASA discretionary awards are subject to a merit review with the objective of selecting the recipient most likely to be successful in delivering results based on the objectives outlined in this Assistance Listing. Applicants may consult the NASA Grant and Cooperative Agreement manual for additional information on NASA Proposal review and selection process. https://www.nasa.gov/grants-policy-and-compliance-team/#Regulations
- Award procedure
After proposals are submitted, NASA evaluates all applications to determine funding selections, and applicants are notified of the outcome by email. Award selection announcements generally occur 150 to 220 days after the proposal due date, following approval of NASA funding through the federal budget process. Selection timelines may be extended due to budget delays, required final approvals and concurrence, or if additional information is needed from the applicant, such as revised budgets or supporting details required to finalize the award.
- Deadlines
Review funding opportunity announcement for specific deadlines and other key dates.
- Time to approval or disapproval
For information on application review procedures, applicants should refer to the applicable section of Proposal Review and Selection Criteria of the GCAM: https://www.nasa.gov/grants-policy-and-compliance-team/#Regulations
- Renewals
Renewal and extension information can be found in the NASA Grant and Cooperative Manual (GCAM) and the NSSC website at https://www.nasa.gov/centers/nssc/grants
- Appeals
Information on NASA appeals policy and process can be found in the NASA Grant and Cooperative Agreement Manual (GCAM), and does not apply to proposals returned without review by NASA for an applicant's failure to: a. Submit a late proposal where information regarding the proposal deadline (i.e., date, time, and location) for submission had been previously specified. b. Meet the NASA proposal preparation requirements, such as page limitations, formatting, instructions, and electronic submission. c. Submit a proposal that is responsive to the NOFO or that contains sufficient detail. d. Submit the proposal with enough lead time before the activity is to commence.
Grant opportunities
Show all 26
Grant awards
Latest 10 of 568 listed here. See the rest on GovTribe.
Top recipients by federal obligations
| Rank | Recipient | Federal obligations | Share |
|---|---|---|---|
| 1 | Center For The Advancement Of Science In Space, Inc. | $225,960,440 | 41% |
| 2 | Teledyne Brown Engineering, Inc. | $39,458,332 | 7% |
| 3 | Texas A & M University | $17,606,677 | 3% |
| 4 | Fraunhofer Usa, Inc. | $12,055,028 | 2% |
| 5 | The Regents Of The University Of Colorado | $9,925,170 | 2% |
| 6 | Loma Linda University | $8,410,566 | 2% |
| 7 | University Of Alabama At Birmingham | $8,006,255 | 1% |
| 8 | Blue Marble Space | $7,626,774 | 1% |
| 9 | University Of Florida | $7,254,872 | 1% |
| 10 | Alpha Space Test And Research Alliance, LLC | $6,588,256 | 1% |
10 of 229 recipients listed here. See the rest on GovTribe.
Federal obligations by fiscal year
| Fiscal year | Federal obligations |
|---|---|
| FY2026 | $10,509,446 |
| FY2025 | $19,397,064 |
| FY2024 | $22,853,920 |
| FY2023 | $13,261,140 |
| FY2022 | $35,686,517 |
| FY2021 | $22,484,682 |
| FY2020 | $40,727,900 |
| FY2019 | $38,191,683 |
| FY2018 | $27,706,014 |
| FY2017 | $13,673,019 |
| FY2016 | $61,631,623 |
| FY2015 | $48,193,624 |
| FY2014 | $28,895,224 |
| FY2013 | $35,994,931 |
| FY2012 | $31,411,693 |
| FY2011 | $13,067,205 |
| FY2010 | $40,000 |
| FY2005 | $20,000 |
Show all 18
Quick answers
What is Assistance Listing 43.007?
Assistance Listing 43.007 is Space Operations, a federal grant program run by National Aeronautics and Space Administration.
What is the CFDA number for Space Operations?
Its CFDA number is 43.007: Assistance Listing numbers were called CFDA numbers before 2018.
How much funding has Assistance Listing 43.007 awarded?
568 grant awards under 43.007 have obligated $544,890,852 in federal funds to 229 recipients.
Who receives the most funding from 43.007?
The recipients obligated the most under Space Operations are Center For The Advancement Of Science In Space, Inc. ($225,960,440), Teledyne Brown Engineering, Inc. ($39,458,332) and Texas A & M University ($17,606,677).
How much did 43.007 obligate in fiscal year 2025?
Grants under 43.007 obligated $19,397,064 in federal funds in fiscal year 2025.
Are there open grant opportunities under 43.007?
No opportunity listed under 43.007 is open now. The latest, NSF/CASIS Transport Phenomena Research at the International Space Station to Benefit Life on Earth, was posted on September 22, 2025.
On GovTribe
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