Small Business Innovation Research (SBIR) Program / Small Business Technology Transfer (STTR) Program

Active

Assistance listing
10.212
Agency
Grant awards
2,885 $557,705,292 in federal obligations

Program facts

Also known as
SBIR/STTR Program - Phase I and II
Assistance type
  • Project Grant
Treasury accounts
  • 12-1502-0-1-352
  • 12-1500-0-1-352
  • 12-1003-0-1-271
More information

Program details come from SAM.gov Assistance Listings. Updated . Grant award figures come from USAspending.gov.

About this program

The Department of Agriculture National Institute of Food and Agriculture (NIFA) administers the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs under Assistance Listing 10.212, funding small-business commercialization of innovative agricultural technologies and products as of the most recent award on September 15, 2026. The program has distributed $557.7 million in federal dollars across 2,885 awards since 2001, with award activity remaining consistent at roughly 120–130 grants per year over the past five years.

NIFA funds small businesses developing disruptive agricultural innovations—technologies that transform research into commercial products with significant market potential or societal benefit. Recent funded projects exemplify this scope: smart camera systems for continuous on-farm insect monitoring, an implant technology to replace surgical piglet castration, sheep reproduction technology enabling artificial insemination, dairy cattle mastitis vaccines, heritage grain snack manufacturing, produce antimicrobial wash systems, and AI-driven tools for rural economic development and emergency response. The portfolio also includes food science innovations (controlled-release fertilizer coatings, biopolymer food ingredients, sustainable packaging), biofuel and biorefinery technologies (forestry waste valorization, whey permeate conversion to sustainable aviation fuel precursors, biochar production from agricultural waste), plant health solutions (beneficial bacteria biofungicides, detection devices for viral crop diseases, weed control robotics and non-chemical systems), livestock management (heat stress mitigation, bull fertility assessment), and infrastructure tools for rural communities (water quality monitoring, cattle inventory verification via satellite imagery and AI, municipal forestry planning software). The program is 100 percent Project Grants, entirely administered by NIFA.

Recent awards cluster in the $124 thousand to $181 thousand range for Phase I and Phase II projects, with completion periods of 8–12 months for Phase I and 12–24 months for Phase II. Phase I aims to demonstrate technical feasibility; Phase II focuses on commercialization and scaling. A Phase I awardee may advance to Phase II only once per project.

Two open solicitations are currently active. USDA-NIFA-SBIR-012221, posted October 1, 2026, with due date November 17, 2026, solicits Phase II proposals; eligibility is limited to prior Phase I recipients. An earlier Phase II opportunity (USDA-NIFA-SBIR-011120) posted July 16, 2025, with due date September 23, 2025, remains listed in the opportunity portfolio. Applicants must register with SAM.gov and Grants.gov before submitting; applications are electronic only. Approval/denial decisions take 30 to 60 days. The source does not list open Phase I solicitations; the most recent Phase I opportunity closed September 17, 2024. Applicants must qualify as small business concerns under SBA rules, with primary employment of the project director/principal investigator at the small business during the award period. Non-profit entities are ineligible for SBIR; only research institutions partnering with small businesses are eligible as STTR collaborators.

Objective and description

Objective

The National Institute of Food and Agriculture (NIFA) administers the U.S. Department of Agriculture's (USDA) Small Business Innovation Research (SBIR) and Technology Transfer (STTR) programs, both of which focus on projects that enhance American agr

Description

The USDA SBIR/STTR programs focus on transforming scientific discovery into products and services with commercial potential and/or societal benefit. Unlike fundamental research, the USDA SBIR/STTR programs support small businesses in the creation of innovative, disruptive technologies and enable the application of research advancements from conception into the market. The STTR program aims to foster technology transfer through formal cooperative research and development between small businesses and nonprofit research institutions. The aim of a Phase I project should be to demonstrate technical feasibility of the proposed innovation and thereby bring the innovation closer to commercialization. Proposals should describe the development of an innovation that demonstrates the following characteristics: 1.) Involves a high degree of technical risk - for example, has never been attempted and/or successfully achieved and is still facing technical hurdles (that the USDA-funded R & D work is intended to overcome). 2.) Has the potential for significant commercial impact and/or societal benefit as evidenced by having the potential to disrupt the targeted market segment; having good product-market fit (as validated by customers); removing barriers to entry for competition; and offering potential for societal benefit (through commercialization under a sustainable business model). 3.) Phase I awards may not exceed the listed maximum award amount for each topic area (listed with specific Program Code) with a project period normally not to exceed eight (8) months for SBIR and twelve (12) months for STTR. 4.) The Phase I application should concentrate on research that will significantly contribute to proving the scientific or technical feasibility of the approach or concept, describe the potential market for the innovation, and be a prerequisite to further USDA SBIR/STTR support in Phase II. The aim of SBIR/STTR Phase II applications is to continue the R & D developed under Phase I with a goal to commercialize and bring the innovation to market as the Phase II project completes. Notice of Funding Opportunities (NOFOs) are generally released annually. See the program NOFO for specific and detailed information. Specific instructions in the NOFOs supersede the general information provided in the Assistance Listing. The programs and associated NOFOs listed under Assistance Listing 10.212 are: 1.) SBIR/STTR Phase I: https://www.nifa.usda.gov/grants/funding-opportunities/small-business-innovation-research-small-business-technology-transfer 2.) SBIR/STTR Phase II: https://www.nifa.usda.gov/grants/funding-opportunities/small-business-innovation-research-small-business-technology

Eligibility

Applicant eligibility

Phase I is open to any eligible small independent US business. Phase II is open only to previous Phase I awardees. The SBIR/STTR Phase I and Phase II NOFOs outline the specific eligibility requirements that are in place to ensure that the funds go only to small, independent US businesses. The regulations include restrictions about 1.) the type of firm; 2.) its ownership structure; and 3.) the firm's size in terms of the number of employees. See the program NOFO for more details about the SBIR/STTR eligibility requirements.

Uses of assistance

The selected areas for research are: 1.) Forests and Related Resources; 2.) Plant Production and Protection (Biology) 3.) Animal Production and Protection; 4.) Management of Natural Resources; 5.) Food Science and Nutrition; 6.) Rural and Community Development; 7.) Aquaculture; 8.) Biofuels and Biobased Products; 9.) Small and Mid-size Farms; and 10.) Plant Production and Protection (Engineering). Phase I projects are supported to determine the scientific or technical feasibility of ideas submitted by small business applicants on the selected research areas. Phase II awards are made to firms with approaches that appear sufficiently promising as a result of Phase I studies. Only those small businesses previously receiving Phase I awards are eligible to submit Phase II proposals.

Use restrictions

The selected areas for research are: 1.) Forests and Related Resources; 2.) Plant Production and Protection (Biology) 3.) Animal Production and Protection; 4.) Management of Natural Resources; 5.) Food Science and Nutrition; 6.) Rural and Community Development; 7.) Aquaculture; 8.) Biofuels and Biobased Products; 9.) Small and Mid-size Farms; and 10.) Plant Production and Protection (Engineering). Phase I projects are supported to determine the scientific or technical feasibility of ideas submitted by small business applicants on the selected research areas. Phase II awards are made to firms with approaches that appear sufficiently promising as a result of Phase I studies. Only those small businesses previously receiving Phase I awards are eligible to submit Phase II proposals.

Length and time phasing of assistance

The proposed duration of Phase I projects should normally not exceed eight (8) months for SBIR and twelve (12) months for STTR. The proposed duration of Phase II projects will not normally exceed twenty-four (24) months. See the program RFAs for more information length and time phasing of assistance.

How to apply

Preapplication coordination

All NOFOs are published on Grants.gov. Applicants must complete the SAM.gov and Grants.gov registration process prior to applying. See the program NOFO for any program specific pre-application requirements.

Criteria for selecting proposals

General application instructions are listed in the NIFA Grants Application Guide. Program-specific instructions are listed in the Notice of Funding Opportunity (NOFO). The NOFO overrides the Application Guide if there is a discrepancy between the two documents. Applicants must apply electronically through Grants.gov; no other method or response is accepted. The application forms package for this funding opportunity must be accessed through Grants.gov. Part III of the NIFA Grants Application Guide explains how to access a specific application forms package. Parts II and III of the NIFA Grants Application Guide contain resources to assist grant applicants and detailed information regarding the Grants.gov registration process. NIFA evaluates each application in a two-part process. First, each application is screened to ensure that it meets the administrative requirements set forth in the NOFO. All administrative requirements must be met in order for the application to proceed to the next level of review. Second, a scientific peer-review process will be used to technically evaluate applications that have met the administrative requirements using a review panel. After each peer review panel has completed deliberations, the responsible NIFA program staff will either recommend an application for support from available funds or decline an application due to insufficient funds or unfavorable review. See the program NOFO for more information.

Award procedure

Within the limit of funds authorized, the NIFA awarding official will make grants to eligible applicants whose applications are judged most meritorious under the procedures set forth in the NOFO. After the award is finalized, a formal notification in the form of a Notice of Award (NoA), signed by the Authorized Departmental Officer, will be provided to the applicant organization for successful applications. The NoA is the authorizing document and will be sent via email to the recipient's Authorized Representative. The NoA will provide pertinent instructions and information including, at a minimum, the information described in 2 CFR 200.211 (see NIFA's Terms and Conditions).

Time to approval or disapproval

Section 094 - Deadlines: Dates for specific deadlines are announced in the NOFO each fiscal year. Information is also available via our website and may be obtained via the Grants.gov website. Respective links are provided below: http://www.nifa.usda.gov/ http://www.grants.gov Section 095 - Range of Approval/Disapproval Time: From 30 to 60 days. Contact the National Program Leader (NPL), as indicated per CFDA Section # 152 - Headquarters Office regarding dates for specific deadlines, start and end dates, and range of approval/disapproval time. Information is also available via our website and may be obtained via the Grants.gov website. NIFA's respective links regarding general information are provided below: http://nifa.usda.gov/ http://www.grants.gov. SPECIAL NOTE: Please refer to the Competitive Notice of Funding Opportunity (NOFOs) for further specific and pertinent details. The most current NOFO is available via: SBIR Phase I https://nifa.usda.gov/funding-opportunity/small-business-innovation-research-program-phase-i SBIR Phase II: https://nifa.usda.gov/funding-opportunity/small-business-innovation-research-program-phase-ii

Renewals

Specific details are provided in the Notice of Funding Opportunity (NOFO), which are generally published annually.

Appeals

Phase I applications may be revised and resubmitted during a later funding cycle, provided the subject matter of the proposal is not changed, and the topic area under which the proposal was originally submitted is still listed in the solicitation. Phase I grantees may apply for a Phase II grant only once for each Phase I project funded. Note: Change "Phase I grantees may apply for a Phase II grant only once for each Phase I project funded." to read as "Only those small businesses previously receiving Phase I awards are eligible to submit Phase II proposals" 2 CFR Part 200 - Subparts D & E apply to this program.

Grant opportunities

Opportunity Status Posted Applications due
Small Business Innovation Research and Small Business Technology Transfer Programs Phase II USDA-NIFA-SBIR-012221 Open
Small Business Innovation Research and Small Business Technology Transfer Programs Phase II USDA-NIFA-SBIR-011120 Closed
Small Business Innovation Research and Small Business Technology Transfer Programs Phase I USDA-NIFA-SBIR-010774 Closed
Small Business Innovation Research and Small Business Technology Transfer Programs Phase II USDA-NIFA-SBIR-010287 Closed
Small Business Innovation Research and Small Business Technology Transfer Programs Phase I USDA-NIFA-SBIR-009962 Closed
Small Business Innovation Research and Small Business Technology Transfer Programs Phase II USDA-NIFA-SBIR-009642 Closed
Small Business Innovation Research and Small Business Technology Transfer Programs Phase I USDA-NIFA-SBIR-009301 Closed
Small Business Innovation Research Program - Phase II USDA-NIFA-SBIR-008801 Closed
Small Business Innovation Research Program Phase I USDA-NIFA-SBIR-008541 Closed
Small Business Innovation Research (SBIR) Program Phase II USDA-NIFA-SBIR-008080 Closed
FY21 Small Business Innovation Research Phase I USDA-NIFA-SBIR-007712 Closed
FY 2020 SBIR Phase 1 - 2nd release USDA-NIFA-SBIR-007374 Closed
FY 2020 FY2021 SBIR Phase II RFA USDA-NIFA-SBIR-007194 Closed
FY 20 and FY21 SBIR Phase I RFA USDA-NIFA-SBIR-006790 Closed
FY19 Small Business Innovation Research Program Phase II USDA-NIFA-SBIR-006692 Closed
Small Business Innovation Research Program Phase I Fiscal Year 2019 USDA-NIFA-SBIR-006649 Closed
Small Business Innovation Research Program Phase II USDA-NIFA-SBIR-006428 Closed
Small Business Innovation Research Program - Phase I USDA-NIFA-SBIR-006365 Closed
Small Business Innovation Research Program Phase II Fiscal Year 2016 USDA-NIFA-SBIR-005455 Closed
Small Business Innovation Research Program Phase I USDA-NIFA-SBIR-005277 Closed
Small Business Innovation Research Program Phase II USDA-NIFA-SBIR-004815 Closed
Show all 21

Grant awards

Award Recipient Federal obligations Awarded
Farmers depend on insects in two very different ways: pollinators such as bees and butterflies help produce crops… 20263361046911 Field Data Services LLC $641,719
Milk is a valuable source of high quality protein, vitamins and minerals and an important contributor to global health… 20267043646789 Pentamer Biologics LLC $649,548
We spend over $50B on snack food each year in america, and calories from those snacks account for nearly a quarter of… 20267003146889 Diggables, Inc. $650,000
This sbir phase II project seeks to demonstrate the commercial feasibility of a next generation analyzer platform… 20264000046658 Foundation Instruments Inc. $600,000
Most male piglets raised for pork in the united states are surgically castrated during their first week of life to… 20263941046787 Insigna, Inc. $650,000
Fresh and fresh-cut produce are vulnerable to microbial contamination during postharvest processing, leading to food… 20263361046890 Mirtech, Inc. $649,957
This project aims to optimize and further scale up an in-line flow-through and chemical-free UV treatment train towards… 20263361046855 Water Illumination Inc. $650,000
The consumption of sheep products continues to increase in the U.S., but instead of making our farmers more prosperous… 20263361046788 Membrane Protective Technologies, Inc. $650,000
Rural communities often struggle with low tax revenue and not enough staff to create strong economic plans, while… 20263361046785 Building Communities, Inc. $650,000
This project advances a scalable, cloud based training and performance platform that addresses persistent communication… 20263361046784 Inxsol LLC $649,998

Latest 10 of 2,885 listed here. See the rest on GovTribe.

Top recipients by federal obligations

Rank Recipient Federal obligations Share
1 Isca Technologies, Inc. $14,899,683 3%
2 TDA Research, Inc. $5,085,288 1%
3 Compact Membrane Systems Inc. $4,008,576 1%
4 Giner, Inc. $3,437,691 1%
5 Ocean Era Inc. $2,812,214 1%
6 All Things Bugs LLC $2,749,500 <1%
7 Membrane Protective Technologies, Inc. $2,513,000 <1%
8 Mirtech, Inc. $2,349,246 <1%
9 Guild Associates Inc. $2,335,934 <1%
10 Isotruss Inc. $2,299,524 <1%

10 of 1,139 recipients listed here. See the rest on GovTribe.

Federal obligations by fiscal year

Fiscal year Federal obligations
FY2026 $6,077,539
FY2025 $21,230,562
FY2024 $40,178,745
FY2023 $41,909,402
FY2022 $34,340,593
FY2021 $26,876,774
FY2020 $26,648,996
FY2019 $24,053,470
FY2018 $28,318,881
FY2017 $23,932,925
FY2016 $27,820,041
FY2015 $20,346,572
FY2014 $18,446,420
FY2013 $17,784,057
FY2012 $16,090,354
FY2011 $21,609,777
FY2010 $22,995,478
FY2009 $16,287,034
FY2008 $18,816,316
FY2007 $19,502,003
FY2006 $13,233,557
FY2005 $15,020,520
FY2004 $15,239,447
FY2003 $13,668,604
FY2002 $14,326,124
FY2001 $13,047,817
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Quick answers

What is Assistance Listing 10.212?

Assistance Listing 10.212 is Small Business Innovation Research (SBIR) Program / Small Business Technology Transfer (STTR) Program, a federal grant program run by National Institute of Food and Agriculture (Department of Agriculture).

What is the CFDA number for Small Business Innovation Research (SBIR) Program / Small Business Technology Transfer (STTR) Program?

Its CFDA number is 10.212: Assistance Listing numbers were called CFDA numbers before 2018.

How much funding has Assistance Listing 10.212 awarded?

2,885 grant awards under 10.212 have obligated $557,705,292 in federal funds to 1,139 recipients.

Who receives the most funding from 10.212?

The recipients obligated the most under Small Business Innovation Research (SBIR) Program / Small Business Technology Transfer (STTR) Program are Isca Technologies, Inc. ($14,899,683), TDA Research, Inc. ($5,085,288) and Compact Membrane Systems Inc. ($4,008,576).

How much did 10.212 obligate in fiscal year 2025?

Grants under 10.212 obligated $21,230,562 in federal funds in fiscal year 2025.

Are there open grant opportunities under 10.212?

1 listed opportunity under 10.212 is open or forecasted. The latest, Small Business Innovation Research and Small Business Technology Transfer Programs Phase II, was posted on October 1, 2026.

On GovTribe

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