Utilizing the PLCO Biospecimens Resource to Bridge Gaps in Cancer Etiology and Early Detection Research (U01 Clinical Trial Not Allowed)
Open Posted
- Opportunity number
- PAR-25-248
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Categories
-
- Education
- Health
- Eligible applicants
-
- Non-501(c)(3) Nonprofits
- State Governments
- Special District Governments
- Higher Education Inst. (Public)
- For Profit Organizations
- Higher Education Inst. (Private)
- Other
- City/Township Governments
- County Governments
- Tribal Organizations (Not Federally Recognized)
- Independent School Districts
- Small Businesses
- Tribal Governments (Federally Recognized)
- Public or Indian Housing Auth.
- 501(c)(3) Nonprofits
- Points of contact
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- NIH OER Webmaster grantsinfo@nih.gov
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health is soliciting applications for a cooperative agreement to advance cancer etiology and early detection research using the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial biorepository, with an application due date of October 8, 2027. The proposed research project must involve use of PLCO biospecimens and take advantage of their unique characteristics; research projects that do not use PLCO biospecimens will not be supported.
Eligible applicants include higher education institutions (public and private), 501(c)(3) and non-501(c)(3) nonprofits, state and local governments, tribal organizations, for-profit organizations, small businesses, and other entities. The FOA also welcomes applications from Historically Black Colleges and Universities, Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions, Tribally Controlled Colleges and Universities, and non-domestic entities.
The PLCO Biorepository provides high-quality, prospectively collected serial pre-diagnostic blood samples from screened arm participants and one-time buccal cell collections from control arm participants, paired with demographic, diet, lifestyle, smoking, screening, and clinical data. Supported research includes biochemical and genetic analyses of cancer risk and discovery and validation of early detection biomarkers. Clinical trials are not permitted under this FOA.
Applications undergo evaluation based on scientific merit and technical adequacy, investigator competency, facility and resource adequacy, budget necessity and proportionality, and relevance to program objectives. Awards are made on a competitive basis through the Cancer Cause and Prevention Research program (CFDA 93.393).
Synopsis
This Funding Opportunity Announcement (FOA) encourages the submission of applications that propose to advance research in cancer etiology and early detection biomarkers, utilizing the advantages of the unique biorepository resources of the NCI-sponsored Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial. The PLCO Biorepository offers high-quality, prospectively collected, serial pre-diagnostic blood samples from the PLCO screened arm participants, and a onetime collection of buccal cells from the control arm participants. Available data associated with the biospecimens includes demographic, diet, lifestyle, smoking, screening results, and clinical data. This FOA supports a wide range of cancer research including, but not limited to, biochemical and genetic analyses of cancer risk, as well as discovery and validation of early detection biomarkers. The proposed research project must involve use of PLCO biospecimens; additionally, it should also take advantage of the unique characteristics of the PLCO biospecimens. Research projects that do not involve the use of PLCO biospecimens will not be supported under this FOA.
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Files
| File | Type | Posted |
|---|---|---|
| PAR-25-248-Full-Announcement.html | HTML file | |
| PKG00288885.pdf |
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