The NIDDK Disorders of Gastrointestinal Interoception Consortium Clinical Centers (DGIC)

Past Federal grant forecast Posted

Opportunity number
RFA-DK-27-118
Agency
Applications expected due
Award size
Not on record

Opportunity facts

Expected posting
Funding instrument
Cooperative Agreement
Category
  • Health
Eligible applicants
  • Tribal Governments (Federally Recognized)
  • County Governments
  • Public or Indian Housing Auth.
  • For Profit Organizations
  • Higher Education Inst. (Private)
  • 501(c)(3) Nonprofits
  • Tribal Organizations (Not Federally Recognized)
  • Higher Education Inst. (Public)
  • Small Businesses
  • State Governments
  • City/Township Governments
  • Other
  • Independent School Districts
  • Special District Governments
Points of contact

Opportunity details come from Grants.gov. Updated .

About this opportunity

Written by GovTribe AI ·

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) seeks applicants for a cooperative agreement to establish the Disorders of Gastrointestinal Interoception Consortium (DGIC) Clinical Centers, a forecast opportunity with no published application deadline. The consortium expands the scope of the prior NIDDK Gastroparesis Consortium (GpCRC) to include adult and pediatric gastrointestinal conditions beyond gastroparesis that involve impaired interoceptive signaling—the nervous system's ability to sense, interpret, and coordinate signals from bodily systems including the GI tract.

Eligible applicants include higher education institutions (public and private), 501(c)(3) nonprofits, for-profit organizations, state and local governments, tribal governments and organizations, small businesses, and other entities including faith-based or community-based organizations, regional organizations, non-domestic entities, and eligible federal agencies. The consortium structure includes up to 6 Clinical Research Centers and a Scientific Data Research Center. The initiative emphasizes multidisciplinary approaches to reveal underlying mechanisms connecting GI function to symptoms, identify disease or response biomarkers assessing treatment efficacy, and leverage state-of-the-art technologies.

The opportunity operates under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research). Award amounts and period of performance are not specified in the forecast announcement. Evaluation criteria include scientific merit and significance of objectives, technical adequacy of experimental design, investigator competency, facility and resource adequacy, budget necessity, and relevance to program objectives. Grantees must retain financial and programmatic records for three years from the date the annual Federal Funds Status Report is submitted.

Forecast synopsis

The National Institute of Diabetes and Digestive Diseases and Nutrition (NIDDK) seeks to advance its mission by continuing the work of the NIDDK Gastroparesis Consortium (GpCRC) but also to expand its scope. The collaborative efforts of the GpCRC provided a large database, the Gastroparesis Registry, which is located in the NIDDK central repository and contains information on patients with symptoms of either delayed or normal gastric emptying. It also houses the first U.S. registry of children and adolescents with gastroparesis. The GpCRC provided clarity and insight that set the stage for transforming our understanding of gastroparesis and laid out a road map for approaching other disorders of gastrointestinal (GI) motility. The findings from clinical studies and trials clearly demonstrated that the clinical burden of gastroparesis is significantly greater than previously realized and involves much more than the stomach. Importantly, the underlying mechanisms remain unclear.

Interoception is the ability of the nervous system to sense, interpret and coordinate signals from various bodily systems including the GI tract. Many functional GI disorders are associated with a spectrum of overlapping symptoms including nausea, vomiting, and altered bowel habits all of which involve altered interoceptive signaling. This initiative would broaden the scope beyond gastroparesis to include other adult and pediatric GI conditions associated with impaired interoceptive processing to form a Disorders of Gastrointestinal Interoception Consortium (DGIC). The consortium may include up to 6 Clinical Research Centers (described in a companion notice) and a Scientific Data Research Center (SDRC). There would be an emphasis on multidisciplinary approaches that would reveal the underlying mechanisms that connect GI function more directly to symptoms, identify disease or response biomarkers that assess treatment efficacy, and leverage state-of-the-art technologies to identify novel therapeutic targets that could be assessed in future clinical trials. The SDRC will coordinate collaboration among the Clinical Research Centers, participant enrollment, biospecimen collections and processing, and manage the submission of data and samples to central databases and repositories.

Eligibility

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

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