The NIDDK Disorders of Gastrointestinal Interoception Consortium Clinical Centers (DGIC)
Forecasted Federal grant Posted
- Opportunity number
- RFA-DK-27-117
- Agency
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National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Not on record
Opportunity facts
- Expected posting
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
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- Health
- Eligible applicants
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- Higher Education Inst. (Public)
- For Profit Organizations
- Independent School Districts
- Other
- Higher Education Inst. (Private)
- Public or Indian Housing Auth.
- Tribal Organizations (Not Federally Recognized)
- 501(c)(3) Nonprofits
- State Governments
- City/Township Governments
- Special District Governments
- County Governments
- Small Businesses
- Tribal Governments (Federally Recognized)
- Points of contact
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- Terez Shea-Donohue, Ph.D. terez.shea-donohue@nih.gov (301) 825-2314
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute of Diabetes and Digestive Diseases and Nutrition (NIDDK) seeks applicants for the Disorders of Gastrointestinal Interoception Consortium Clinical Centers (DGIC), a cooperative agreement opportunity with no posted application deadline in the source material.
Eligible applicants include higher education institutions (public and private), for-profit organizations, nonprofits (501(c)(3)), state and local governments, tribal governments (federally recognized and non-federally recognized tribal organizations), small businesses, housing authorities, school districts, faith-based and community-based organizations, regional organizations, U.S. territories and possessions, and non-domestic entities.
The consortium will comprise up to six Clinical Research Centers and a Scientific Data Research Center. The DGIC expands the scope of the predecessor NIDDK Gastroparesis Consortium (GpCRC) to encompass adult and pediatric gastrointestinal conditions associated with impaired interoceptive processing—the nervous system's ability to sense, interpret, and coordinate signals from bodily systems including the gastrointestinal tract. Many functional GI disorders present with overlapping symptoms including nausea, vomiting, and altered bowel habits involving altered interoceptive signaling.
The consortium will employ multidisciplinary approaches to reveal underlying mechanisms connecting GI function to symptoms, identify disease or response biomarkers assessing treatment efficacy, and leverage state-of-the-art methodology. The DGIC builds on the GpCRC's substantial database, the Gastroparesis Registry, housed in the NIDDK central repository and containing information on patients with delayed or normal gastric emptying, including the first U.S. registry of children and adolescents with gastroparesis.
The opportunity is funded under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
Forecast synopsis
The National Institute of Diabetes and Digestive Diseases and Nutrition (NIDDK) seeks to advance its mission by continuing the work of the NIDDK Gastroparesis Consortium (GpCRC) but also to expand its scope. The collaborative efforts of the GpCRC provided a large database, the Gastroparesis Registry, which is located in the NIDDK central repository and contains information on patients with symptoms of either delayed or normal gastric emptying. It also houses the first U.S. registry of children and adolescents with gastroparesis. The GpCRC provided clarity and insight that set the stage for transforming our understanding of gastroparesis and laid out a road map for approaching other disorders of gastrointestinal (GI) motility. The findings from clinical studies and trials clearly demonstrated that the clinical burden of gastroparesis is significantly greater than previously realized and involves much more than the stomach. Importantly, the underlying mechanisms remain unclear.
Interoception is the ability of the nervous system to sense, interpret and coordinate signals from various bodily systems including the gastrointestinal tract. Many functional GI disorders are associated with a spectrum of overlapping symptoms including nausea, vomiting, and altered bowel habits all of which involve altered interoceptive signaling. This initiative would broaden the scope beyond gastroparesis to include other adult and pediatric GI conditions associated with impaired interoceptive processing to form a Disorders of Gastrointestinal Interoception Consortium (DGIC). The consortium may include up to 6 Clinical Research Centers and a Scientific Data Research Center (SDRC, described in a companion notice). There would be an emphasis on multidisciplinary approaches that would reveal the underlying mechanisms that connect GI function (e.g motility) more directly to symptoms, identify disease or response biomarkers that assess treatment efficacy, and leverage state-of-the-art technologies to identify novel therapeutic targets that could be assessed in future clinical trials.
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
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