Testing Centers for Evaluation of Somatic Cell Genome Editing Approaches for Translational Applications (U42 Clinical Trial Not Allowed)
Forecasted Federal grant Posted
- Opportunity number
- PAR-28-084
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- $580,000 to $900,000
Opportunity facts
- Expected posting
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- Non-501(c)(3) Nonprofits
- For Profit Organizations
- Tribal Governments (Federally Recognized)
- 501(c)(3) Nonprofits
- Other
- State Governments
- Independent School Districts
- Higher Education Inst. (Private)
- Special District Governments
- Higher Education Inst. (Public)
- Small Businesses
- Public or Indian Housing Auth.
- County Governments
- City/Township Governments
- Tribal Organizations (Not Federally Recognized)
- Points of contact
-
- Oleg Mirochnitchenko oripdcm@mail.nih.gov (301) 435-0744
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health is soliciting applications through a cooperative agreement to establish Testing Centers for Evaluation of Somatic Cell Genome Editing Approaches for Translational Applications. Clinical trials are not permitted under this funding mechanism.
Eligible applicants include 501(c)(3) nonprofits, non-501(c)(3) nonprofits, for-profit organizations, higher education institutions (public and private), small businesses, state and local governments, tribal governments (federally recognized and not federally recognized), tribal organizations, special district governments, public or Indian housing authorities, independent school districts, regional organizations, faith-based or community-based organizations, eligible federal agencies, and U.S. territories or possessions.
Each Testing Center will establish in vivo and in vitro research models applicable to human health and disease, including new approach methodologies (NAMs) and human-biology-based models. Centers will develop assays and Standard Operating Procedures for evaluating genome editing technologies; assess efficacy and safety of genome editing and delivery technologies; determine genome editing thresholds for specific diseases with minimal off-target effects; and ascertain feasibility parameters in model systems. While each center will focus on a limited number of projects, the program pipeline is expected to build core model systems adaptable to a broad spectrum of diseases and provide fee-for-service resources to the biomedical community on local, regional, and national bases.
The program aims to provide research resources that facilitate optimization and enhance scientific rigor, transparency, and experimental reproducibility. Data generated will help determine whether treatment strategies using specific genome editing tools are effective, have acceptable safety profiles, or require improvement in editing efficacy and specificity.
This opportunity is assigned to CFDA 93.351 (Research Infrastructure Programs) under the National Institutes of Health Office of Research Infrastructure Programs.
Forecast synopsis
This Notice of Funding Opportunity (NOFO) invites applicants to support Testing Centers for Evaluation of Somatic Cell Genome Editing Approaches for Translational Applications. Each center will provide resources and testing services to the growing community, developing new genome editing technologies and conducting preclinical testing based on these technologies for therapeutics for human diseases. The testing centers will work with NIH-funded investigators to assess the efficacy and safety of genome editing and delivery technologies, determine genome editing thresholds for specific diseases associated with minimal off-target effects, and ascertain feasibility parameters in model systems. This NOFO is especially interested in the application of new approach methodologies (NAMs) to complement traditional in vivo models for the purposes described in this announcement.
Research Initiative Details
The Testing Centers will establish in vivo and in vitro research models applicable to human health and disease, including NAMs and human-biology-based models. The Testing Centers will develop assays and Standard Operating Procedures (SOPs) for evaluating new genome editing technologies. Data generated by the Centers will help determine whether a treatment strategy using a specific set of tools is effective, has an acceptable safety profile, or requires significant improvement in editing efficacy and specificity. Although each Testing Center will work on a limited number of focused projects, the program and pipeline(s) developed are expected to support multifaceted research activities, build core model systems that can be adapted to accommodate a broad spectrum of diseases, and provide fee-for-service resources to the wider biomedical community on a local, regional, and national basis.
The goal of projects supported by this NOFO is to provide research resources that facilitate optimization and enhance scientific rigor, transparency, and experimental reproducibility in biomedical research.
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations.
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