Single Source: Post-Stroke Vascular Contributions to Cognitive Impairment and Dementia (VCID) in the United States (U19 - Clinical Trial Not Allowed)
Closed Posted
- Opportunity number
- RFA-NS-27-011
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- 501(c)(3) Nonprofits
- Higher Education Inst. (Private)
- State Governments
- Small Businesses
- City/Township Governments
- Independent School Districts
- For Profit Organizations
- Higher Education Inst. (Public)
- Other
- County Governments
- Non-501(c)(3) Nonprofits
- Tribal Governments (Federally Recognized)
- Tribal Organizations (Not Federally Recognized)
- Public or Indian Housing Auth.
- Special District Governments
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute of Neurological Disorders and Stroke (NINDS), in collaboration with the National Institute on Aging, is awarding a single-source cooperative agreement to fund post-stroke vascular contributions to cognitive impairment and dementia (VCID) research, with applications due September 28, 2026. This non-competitive funding opportunity is restricted to Massachusetts General Hospital; only principal investigators and project directors previously associated with the original U19 award (RFA-NS-19-012) to that institution are eligible to apply.
NINDS intends to commit up to $10,000,000 in total FY 2027 funds, with direct costs not to exceed $26,700,000 over a 4-year project period. The award funds one large prospective clinical research study to determine associations between stroke subtypes and subsequent cognitive impairment and dementia in U.S. post-stroke populations. The application must include five required components: Overall, Administrative Core, Statistics Core, Recruitment and Retention Core, and Repository Core, each with specific page limitations and staffing requirements submitted in multi-project format. The Contact PD/PI must commit at least 3 calendar months annually to the project and serve as Administrative Core Lead.
The research strategy must address stroke subtypes, cognitive trajectories, biomarkers including amyloid-beta and tau, and comorbidities along the Alzheimer's Disease spectrum, with demonstrated robust progress from the initial award. A Data Management and Sharing Plan is mandatory. Applicants must adhere to MarkVCID standards for clinical data and biospecimens and coordinate with existing VCID resources. Substantial NIH programmatic involvement includes a Project Steering Committee with NINDS Project Scientists, an independent Oversight and Safety Monitoring Board, and quarterly conference calls. The award operates under CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders) and CFDA 93.866 (Aging Research).
Synopsis
This is a non-competitive funding opportunity intended to fund a single award. The National Institute of Neurological Disorders and Stroke is announcing its intent to issue a single source cooperative agreement award to Massachusetts General Hospital to support the renewal of the Post-Stroke Vascular Cognitive Impairment & Dementia (VCID) program, an ongoing, multi-site clinical research initiative designed to elucidate mechanisms linking stroke to subsequent cognitive impairment and dementia. The award will enable completion of the scientific aims initiated under the original U19 cooperative agreement (RFA-NS-19-012) and advance national priorities described in the National Plan to Address Alzheimer"s Disease.This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invite an application from Massachusetts General Hospital. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application will be peer-reviewed, and only meritorious application(s) will be considered for funding.
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Only those who received a grant award under RFA-NS-19-012 are eligible to apply. Only the following applicant is eligible to apply for this single source funding: Massachusetts General Hospital. Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Files
| File | Type | Posted |
|---|---|---|
| PKG00293516.pdf | ||
| RFA-NS-27-011-Full-Announcement.html | HTML file |
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